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[Nutritional status and intestinal iron absorption in children with chronic hepatic disease with and without cholestasis].
J Pediatr (Rio J) 2005 Jul-Aug; 81(4):317-24JP

Abstract

OBJECTIVE

To evaluate food intake, occurrence of energy-protein malnutrition and anemia, and intestinal iron absorption in children with chronic liver disease.

METHODS

The study included 25 children with chronic liver disease, 14 with cholestasis and 11 without cholestasis. The age varied between 6.5 months and 12.1 years. Intestinal iron absorption was evaluated by the increment of serum iron one hour after the ingestion of 1 mg/kg of elemental iron and by the response to oral iron therapy. Iron intestinal absorption was compared to a group with iron deficiency anemia (without liver disease).

RESULTS

The mean intake of energy and protein in the cholestatic group was higher than in patients without cholestasis. The nutritional deficit was more severe in cholestatic patients, especially with regard to height-for-age and weight-for-age indices. Anemia was found in both cholestatic group (11/14; 78.6%) and noncholestatic group (7/11; 63.6%). The cholestatic group presented lower (p < 0.05) intestinal iron absorption (90.6+/-42.1 microg/dl) than the iron deficiency anemia group (159.6+/-69.9 microg/dl). However, cholestatic patients responded to oral iron therapy. The noncholestatic group showed intestinal iron absorption similar to the iron deficiency anemia group.

CONCLUSION

The cholestatic group showed more severe nutritional deficits. Despite the evidence of lower iron intestinal absorption, cholestatic patients responded to oral iron therapy, probably, due to the coexistence of iron deficiency.

Authors+Show Affiliations

Universidade Federal de São Paulo-Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

por

PubMed ID

16106317

Citation

Mattar, Regina Helena G da Motta, et al. "[Nutritional Status and Intestinal Iron Absorption in Children With Chronic Hepatic Disease With and Without Cholestasis]." Jornal De Pediatria, vol. 81, no. 4, 2005, pp. 317-24.
Mattar RH, Azevedo RA, Speridião PG, et al. [Nutritional status and intestinal iron absorption in children with chronic hepatic disease with and without cholestasis]. J Pediatr (Rio J). 2005;81(4):317-24.
Mattar, R. H., Azevedo, R. A., Speridião, P. G., Fagundes Neto, U., & Morais, M. B. (2005). [Nutritional status and intestinal iron absorption in children with chronic hepatic disease with and without cholestasis]. Jornal De Pediatria, 81(4), pp. 317-24.
Mattar RH, et al. [Nutritional Status and Intestinal Iron Absorption in Children With Chronic Hepatic Disease With and Without Cholestasis]. J Pediatr (Rio J). 2005;81(4):317-24. PubMed PMID: 16106317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Nutritional status and intestinal iron absorption in children with chronic hepatic disease with and without cholestasis]. AU - Mattar,Regina Helena G da Motta, AU - Azevedo,Ramiro Anthero de, AU - Speridião,Patrícia G L, AU - Fagundes Neto,Ulysses, AU - Morais,Mauro Batista de, PY - 2005/8/18/pubmed PY - 2006/2/17/medline PY - 2005/8/18/entrez SP - 317 EP - 24 JF - Jornal de pediatria JO - J Pediatr (Rio J) VL - 81 IS - 4 N2 - OBJECTIVE: To evaluate food intake, occurrence of energy-protein malnutrition and anemia, and intestinal iron absorption in children with chronic liver disease. METHODS: The study included 25 children with chronic liver disease, 14 with cholestasis and 11 without cholestasis. The age varied between 6.5 months and 12.1 years. Intestinal iron absorption was evaluated by the increment of serum iron one hour after the ingestion of 1 mg/kg of elemental iron and by the response to oral iron therapy. Iron intestinal absorption was compared to a group with iron deficiency anemia (without liver disease). RESULTS: The mean intake of energy and protein in the cholestatic group was higher than in patients without cholestasis. The nutritional deficit was more severe in cholestatic patients, especially with regard to height-for-age and weight-for-age indices. Anemia was found in both cholestatic group (11/14; 78.6%) and noncholestatic group (7/11; 63.6%). The cholestatic group presented lower (p < 0.05) intestinal iron absorption (90.6+/-42.1 microg/dl) than the iron deficiency anemia group (159.6+/-69.9 microg/dl). However, cholestatic patients responded to oral iron therapy. The noncholestatic group showed intestinal iron absorption similar to the iron deficiency anemia group. CONCLUSION: The cholestatic group showed more severe nutritional deficits. Despite the evidence of lower iron intestinal absorption, cholestatic patients responded to oral iron therapy, probably, due to the coexistence of iron deficiency. SN - 0021-7557 UR - https://www.unboundmedicine.com/medline/citation/16106317/[Nutritional_status_and_intestinal_iron_absorption_in_children_with_chronic_hepatic_disease_with_and_without_cholestasis]_ L2 - http://www.jped.com.br/conteudo/05-81-04-317/ing.asp DB - PRIME DP - Unbound Medicine ER -