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Antipyretic and analgesic activities of Caesalpinia bonducella seed kernel extract.
Phytother Res. 2005 May; 19(5):376-81.PR

Abstract

Ethanolic extract (70%) of Caesalpinia bonducella seed kernel has been subjected for its antipyretic and antinociceptive activities in adult albino rats or mice of either sex at 30, 100 and 300 mg/kg orally. The extract demonstrated marked antipyretic activity against Brewer's yeast-induced pyrexia in rats. The extract had significant central analgesic activity in hot plate and tail flick methods. It also exhibited marked peripheral analgesic effect in both acetic acid-induced writhing test in mice and Randall-Selitto assay in rats. It also significantly inhibited the formalin-induced hind paw licking in mice. In conclusion, the present study suggests that the ethanolic extract of Caesalpinia bonducella seed kernel possesses potent antipyretic and antinociceptive activities and thus, validates its use in the treatment of pain and pyretic disorders.

Authors+Show Affiliations

Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16106383

Citation

Archana, P, et al. "Antipyretic and Analgesic Activities of Caesalpinia Bonducella Seed Kernel Extract." Phytotherapy Research : PTR, vol. 19, no. 5, 2005, pp. 376-81.
Archana P, Tandan SK, Chandra S, et al. Antipyretic and analgesic activities of Caesalpinia bonducella seed kernel extract. Phytother Res. 2005;19(5):376-81.
Archana, P., Tandan, S. K., Chandra, S., & Lal, J. (2005). Antipyretic and analgesic activities of Caesalpinia bonducella seed kernel extract. Phytotherapy Research : PTR, 19(5), 376-81.
Archana P, et al. Antipyretic and Analgesic Activities of Caesalpinia Bonducella Seed Kernel Extract. Phytother Res. 2005;19(5):376-81. PubMed PMID: 16106383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antipyretic and analgesic activities of Caesalpinia bonducella seed kernel extract. AU - Archana,P, AU - Tandan,S K, AU - Chandra,S, AU - Lal,J, PY - 2005/8/18/pubmed PY - 2005/10/7/medline PY - 2005/8/18/entrez SP - 376 EP - 81 JF - Phytotherapy research : PTR JO - Phytother Res VL - 19 IS - 5 N2 - Ethanolic extract (70%) of Caesalpinia bonducella seed kernel has been subjected for its antipyretic and antinociceptive activities in adult albino rats or mice of either sex at 30, 100 and 300 mg/kg orally. The extract demonstrated marked antipyretic activity against Brewer's yeast-induced pyrexia in rats. The extract had significant central analgesic activity in hot plate and tail flick methods. It also exhibited marked peripheral analgesic effect in both acetic acid-induced writhing test in mice and Randall-Selitto assay in rats. It also significantly inhibited the formalin-induced hind paw licking in mice. In conclusion, the present study suggests that the ethanolic extract of Caesalpinia bonducella seed kernel possesses potent antipyretic and antinociceptive activities and thus, validates its use in the treatment of pain and pyretic disorders. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/16106383/Antipyretic_and_analgesic_activities_of_Caesalpinia_bonducella_seed_kernel_extract_ L2 - https://doi.org/10.1002/ptr.1339 DB - PRIME DP - Unbound Medicine ER -