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Acute lymphoblastic leukemia presenting in fulminant hepatic failure.
Pediatr Blood Cancer. 2006 Nov; 47(6):842-5.PB

Abstract

A previously healthy 4-year-old boy was admitted because of acute liver failure. He was icteric, lethargic, had elevated ammonia and abnormal liver function tests. Serology was negative for viral hepatitis. There was no history of hepatotoxic drugs. Family history was unremarkable. The child was taken to the operating room for a living-related hepatic transplant. Frozen section showed massive hepatic leukemic infiltration and hepatocellular necrosis. Bone marrow aspiration confirmed the diagnosis of acute lymphoblastic leukemia (ALL). Transplant was withheld and chemotherapy was attempted. He died the following day due to systemic leukemic infiltration, cerebral edema, and severe anoxic ischemic encephalopathy.

Authors+Show Affiliations

University of Texas Southwestern, Dallas, TX, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16106432

Citation

Litten, Jason B., et al. "Acute Lymphoblastic Leukemia Presenting in Fulminant Hepatic Failure." Pediatric Blood & Cancer, vol. 47, no. 6, 2006, pp. 842-5.
Litten JB, Rodríguez MM, Maniaci V. Acute lymphoblastic leukemia presenting in fulminant hepatic failure. Pediatr Blood Cancer. 2006;47(6):842-5.
Litten, J. B., Rodríguez, M. M., & Maniaci, V. (2006). Acute lymphoblastic leukemia presenting in fulminant hepatic failure. Pediatric Blood & Cancer, 47(6), 842-5.
Litten JB, Rodríguez MM, Maniaci V. Acute Lymphoblastic Leukemia Presenting in Fulminant Hepatic Failure. Pediatr Blood Cancer. 2006;47(6):842-5. PubMed PMID: 16106432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute lymphoblastic leukemia presenting in fulminant hepatic failure. AU - Litten,Jason B, AU - Rodríguez,Maria M, AU - Maniaci,Vincenzo, PY - 2005/8/18/pubmed PY - 2007/2/14/medline PY - 2005/8/18/entrez SP - 842 EP - 5 JF - Pediatric blood & cancer JO - Pediatr Blood Cancer VL - 47 IS - 6 N2 - A previously healthy 4-year-old boy was admitted because of acute liver failure. He was icteric, lethargic, had elevated ammonia and abnormal liver function tests. Serology was negative for viral hepatitis. There was no history of hepatotoxic drugs. Family history was unremarkable. The child was taken to the operating room for a living-related hepatic transplant. Frozen section showed massive hepatic leukemic infiltration and hepatocellular necrosis. Bone marrow aspiration confirmed the diagnosis of acute lymphoblastic leukemia (ALL). Transplant was withheld and chemotherapy was attempted. He died the following day due to systemic leukemic infiltration, cerebral edema, and severe anoxic ischemic encephalopathy. SN - 1545-5009 UR - https://www.unboundmedicine.com/medline/citation/16106432/Acute_lymphoblastic_leukemia_presenting_in_fulminant_hepatic_failure_ L2 - https://doi.org/10.1002/pbc.20544 DB - PRIME DP - Unbound Medicine ER -