Tags

Type your tag names separated by a space and hit enter

Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system.
Life Sci. 2006 Feb 28; 78(14):1592-7.LS

Abstract

The present study was undertaken to determine the effects of intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) melatonin on mechanical allodynia and thermal hyperalgesia in mice with partial tight ligation of the sciatic nerve, and how the nitric oxide (NO) precursor l-arginine and the opiate antagonist naloxone influence this effect. A plantar analgesic meter was used to assess thermal hyperalgesia, and nerve injury-induced mechanical hyperalgesia was assessed with von Frey filaments. 1-5 weeks following the surgery, marked mechanical allodynia and thermal hyperalgesia developed in neuropathic mice. Intracerebroventricular and intraperitoneal melatonin, with its higher doses, produced a blockade of thermal hyperalgesia, but not mechanical allodynia. Administration of both l-arginine and naloxone, at doses which produced no effect on their own, partially reversed antihyperalgesic effect of melatonin. These results suggest that although it has different effects on neuropathic pain-related behaviors, melatonin may have clinical utility in neuropathic pain therapy in the future. It is also concluded that l-arginine-NO pathway and opioidergic system are involved in the antihyperalgesic effect of melatonin in nerve-injured mice.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, Trakya University, 22030-Edirne, Turkey. aulugol@trakya.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16107259

Citation

Ulugol, Ahmet, et al. "Antihyperalgesic, but Not Antiallodynic, Effect of Melatonin in Nerve-injured Neuropathic Mice: Possible Involvements of the L-arginine-NO Pathway and Opioid System." Life Sciences, vol. 78, no. 14, 2006, pp. 1592-7.
Ulugol A, Dokmeci D, Guray G, et al. Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system. Life Sci. 2006;78(14):1592-7.
Ulugol, A., Dokmeci, D., Guray, G., Sapolyo, N., Ozyigit, F., & Tamer, M. (2006). Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system. Life Sciences, 78(14), 1592-7.
Ulugol A, et al. Antihyperalgesic, but Not Antiallodynic, Effect of Melatonin in Nerve-injured Neuropathic Mice: Possible Involvements of the L-arginine-NO Pathway and Opioid System. Life Sci. 2006 Feb 28;78(14):1592-7. PubMed PMID: 16107259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system. AU - Ulugol,Ahmet, AU - Dokmeci,Dikmen, AU - Guray,Gurkan, AU - Sapolyo,Nese, AU - Ozyigit,Filiz, AU - Tamer,Melek, Y1 - 2005/08/16/ PY - 2005/02/16/received PY - 2005/07/21/accepted PY - 2005/8/19/pubmed PY - 2006/4/15/medline PY - 2005/8/19/entrez SP - 1592 EP - 7 JF - Life sciences JO - Life Sci VL - 78 IS - 14 N2 - The present study was undertaken to determine the effects of intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) melatonin on mechanical allodynia and thermal hyperalgesia in mice with partial tight ligation of the sciatic nerve, and how the nitric oxide (NO) precursor l-arginine and the opiate antagonist naloxone influence this effect. A plantar analgesic meter was used to assess thermal hyperalgesia, and nerve injury-induced mechanical hyperalgesia was assessed with von Frey filaments. 1-5 weeks following the surgery, marked mechanical allodynia and thermal hyperalgesia developed in neuropathic mice. Intracerebroventricular and intraperitoneal melatonin, with its higher doses, produced a blockade of thermal hyperalgesia, but not mechanical allodynia. Administration of both l-arginine and naloxone, at doses which produced no effect on their own, partially reversed antihyperalgesic effect of melatonin. These results suggest that although it has different effects on neuropathic pain-related behaviors, melatonin may have clinical utility in neuropathic pain therapy in the future. It is also concluded that l-arginine-NO pathway and opioidergic system are involved in the antihyperalgesic effect of melatonin in nerve-injured mice. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/16107259/Antihyperalgesic_but_not_antiallodynic_effect_of_melatonin_in_nerve_injured_neuropathic_mice:_Possible_involvements_of_the_L_arginine_NO_pathway_and_opioid_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(05)00753-8 DB - PRIME DP - Unbound Medicine ER -