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Influence of growth hormone on the craniofacial complex of transgenic mice.
Eur J Orthod. 2005 Oct; 27(5):494-500.EJ

Abstract

Growth hormone (GH) secretion affects bone and cartilage physiology. This study investigated the effect of GH on the size of the craniofacial structures and their angular relationship. Three different models of mice with a genetically altered GH axis were used: GH excess (giant), dwarf GH antagonist (dwarf-Ant), and dwarf GH receptor knockout (dwarf-KO) mice. Each model was compared with the corresponding wild type (Wt). Five craniofacial distances were analysed: craniofacial length, upper face height, mandibular anterior height, mandibular ramus length, and mandibular corpus length. In addition, upper and lower incisor lengths and four angular relationships, nasal bone with cranial base, maxillary plane with cranial base, mandibular plane with cranial base, and the angle of the mandible, were determined. Data were analysed by one-way ANOVA. Craniofacial length, upper face height and mandibular corpus length were significantly increased in the giant mice and significantly reduced in the dwarf mice. Mandibular anterior height and mandibular ramus length were significantly affected in the dwarf-KO mice but not in the giant mice. The length of both the upper and lower incisors was significantly increased and reduced in the giant and dwarf-KO mice, respectively. In addition, the angle of the mandible was significantly increased in the giant mice and significantly reduced in the dwarf mice. It is concluded that GH plays a major role in the growth and development of the craniofacial complex by directly and indirectly modulating the size and the angular relationships of the craniofacial structures, including the incisor teeth.

Authors+Show Affiliations

Department of Dentistry, University of Queensland, St. Lucia, Queensland 4072, Australia. g.ramirez@mailbox.uq.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16107429

Citation

Ramirez-Yañez, German Omar, et al. "Influence of Growth Hormone On the Craniofacial Complex of Transgenic Mice." European Journal of Orthodontics, vol. 27, no. 5, 2005, pp. 494-500.
Ramirez-Yañez GO, Smid JR, Young WG, et al. Influence of growth hormone on the craniofacial complex of transgenic mice. Eur J Orthod. 2005;27(5):494-500.
Ramirez-Yañez, G. O., Smid, J. R., Young, W. G., & Waters, M. J. (2005). Influence of growth hormone on the craniofacial complex of transgenic mice. European Journal of Orthodontics, 27(5), 494-500.
Ramirez-Yañez GO, et al. Influence of Growth Hormone On the Craniofacial Complex of Transgenic Mice. Eur J Orthod. 2005;27(5):494-500. PubMed PMID: 16107429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of growth hormone on the craniofacial complex of transgenic mice. AU - Ramirez-Yañez,German Omar, AU - Smid,Joseph R, AU - Young,William George, AU - Waters,Michael J, Y1 - 2005/08/17/ PY - 2005/8/19/pubmed PY - 2005/11/15/medline PY - 2005/8/19/entrez SP - 494 EP - 500 JF - European journal of orthodontics JO - Eur J Orthod VL - 27 IS - 5 N2 - Growth hormone (GH) secretion affects bone and cartilage physiology. This study investigated the effect of GH on the size of the craniofacial structures and their angular relationship. Three different models of mice with a genetically altered GH axis were used: GH excess (giant), dwarf GH antagonist (dwarf-Ant), and dwarf GH receptor knockout (dwarf-KO) mice. Each model was compared with the corresponding wild type (Wt). Five craniofacial distances were analysed: craniofacial length, upper face height, mandibular anterior height, mandibular ramus length, and mandibular corpus length. In addition, upper and lower incisor lengths and four angular relationships, nasal bone with cranial base, maxillary plane with cranial base, mandibular plane with cranial base, and the angle of the mandible, were determined. Data were analysed by one-way ANOVA. Craniofacial length, upper face height and mandibular corpus length were significantly increased in the giant mice and significantly reduced in the dwarf mice. Mandibular anterior height and mandibular ramus length were significantly affected in the dwarf-KO mice but not in the giant mice. The length of both the upper and lower incisors was significantly increased and reduced in the giant and dwarf-KO mice, respectively. In addition, the angle of the mandible was significantly increased in the giant mice and significantly reduced in the dwarf mice. It is concluded that GH plays a major role in the growth and development of the craniofacial complex by directly and indirectly modulating the size and the angular relationships of the craniofacial structures, including the incisor teeth. SN - 0141-5387 UR - https://www.unboundmedicine.com/medline/citation/16107429/Influence_of_growth_hormone_on_the_craniofacial_complex_of_transgenic_mice_ L2 - https://academic.oup.com/ejo/article-lookup/doi/10.1093/ejo/cji028 DB - PRIME DP - Unbound Medicine ER -