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A family history of diabetes is related to abnormal insulin sensitivity in African-Caribbean girls of low birth weight: is catch-up weight important?
Ethn Dis. 2005 Summer; 15(3):424-8.ED

Abstract

This retrospective cohort study examined the relationship of birth weight, family history of diabetes (FamHx), and current weight to insulin resistance in Black girls and boys on the Caribbean island of Barbados. A cohort of 56 low birth weight (LBW) and 120 normal birth weight (NBW) adolescents born between January 1, 1986, and December 31, 1988, were recruited for study participation in 2002. FamHx was ascertained by questionnaire. Body mass index (BMI) and waist circumference (WC) were used to assess fat distribution. Fasting blood glucose and insulin were measured from blood samples drawn from each adolescent participant. Insulin resistance was estimated by the homeostasis model assessment (HOMA) technique. These data show that only among LBW girls was a positive (+) FamHx associated with higher HOMA (FamHx "Yes"=1.22 +/- 0.298 vs "No"=0.811 +/- 0.452; P=.032). No significant relationships were observed among boys. Further analyses revealed that compared to their NBW counterparts, LBW girls without FamHx, had a smaller WC (69.70 +/- 9.88cm vs 76.70 +/- 15.64cm, respectively; P=.055). In contrast, LBW girls with a (+) FamHx had similar mean WC (77.71 +/- 16.46cm) to those of NBW girls with (+) FamHx (WC=71.50 +/- 10.38cm; P=.405). These data indicate that along with a family history of diabetes, catch-up weight may be important in assessing diabetes risk in Black Caribbean LBW adolescent girls.

Authors+Show Affiliations

Minority International Research Training Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. ecc2106@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16108302

Citation

Chambers, Earle C., et al. "A Family History of Diabetes Is Related to Abnormal Insulin Sensitivity in African-Caribbean Girls of Low Birth Weight: Is Catch-up Weight Important?" Ethnicity & Disease, vol. 15, no. 3, 2005, pp. 424-8.
Chambers EC, Tull ES, Fraser H, et al. A family history of diabetes is related to abnormal insulin sensitivity in African-Caribbean girls of low birth weight: is catch-up weight important? Ethn Dis. 2005;15(3):424-8.
Chambers, E. C., Tull, E. S., Fraser, H., Mutunhu, N. R., Sobers, N. P., & Niles, E. (2005). A family history of diabetes is related to abnormal insulin sensitivity in African-Caribbean girls of low birth weight: is catch-up weight important? Ethnicity & Disease, 15(3), 424-8.
Chambers EC, et al. A Family History of Diabetes Is Related to Abnormal Insulin Sensitivity in African-Caribbean Girls of Low Birth Weight: Is Catch-up Weight Important. Ethn Dis. 2005;15(3):424-8. PubMed PMID: 16108302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A family history of diabetes is related to abnormal insulin sensitivity in African-Caribbean girls of low birth weight: is catch-up weight important? AU - Chambers,Earle C, AU - Tull,Eugene S, AU - Fraser,Henry, AU - Mutunhu,Nyasha R, AU - Sobers,Natasha P, AU - Niles,Elisa, PY - 2005/8/20/pubmed PY - 2005/11/9/medline PY - 2005/8/20/entrez SP - 424 EP - 8 JF - Ethnicity & disease JO - Ethn Dis VL - 15 IS - 3 N2 - This retrospective cohort study examined the relationship of birth weight, family history of diabetes (FamHx), and current weight to insulin resistance in Black girls and boys on the Caribbean island of Barbados. A cohort of 56 low birth weight (LBW) and 120 normal birth weight (NBW) adolescents born between January 1, 1986, and December 31, 1988, were recruited for study participation in 2002. FamHx was ascertained by questionnaire. Body mass index (BMI) and waist circumference (WC) were used to assess fat distribution. Fasting blood glucose and insulin were measured from blood samples drawn from each adolescent participant. Insulin resistance was estimated by the homeostasis model assessment (HOMA) technique. These data show that only among LBW girls was a positive (+) FamHx associated with higher HOMA (FamHx "Yes"=1.22 +/- 0.298 vs "No"=0.811 +/- 0.452; P=.032). No significant relationships were observed among boys. Further analyses revealed that compared to their NBW counterparts, LBW girls without FamHx, had a smaller WC (69.70 +/- 9.88cm vs 76.70 +/- 15.64cm, respectively; P=.055). In contrast, LBW girls with a (+) FamHx had similar mean WC (77.71 +/- 16.46cm) to those of NBW girls with (+) FamHx (WC=71.50 +/- 10.38cm; P=.405). These data indicate that along with a family history of diabetes, catch-up weight may be important in assessing diabetes risk in Black Caribbean LBW adolescent girls. SN - 1049-510X UR - https://www.unboundmedicine.com/medline/citation/16108302/A_family_history_of_diabetes_is_related_to_abnormal_insulin_sensitivity_in_African_Caribbean_girls_of_low_birth_weight:_is_catch_up_weight_important L2 - https://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -