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Hyperproinsulinaemia and risk of Type 2 diabetes mellitus in women.
Diabet Med 2005; 22(9):1178-84DM

Abstract

AIMS

Our objective was to examine prospectively the associations between fasting plasma proinsulin and the proinsulin/insulin ratio and the incidence of Type 2 diabetes in women.

SUBJECTS AND METHODS

We designed a nested case-control study within the Nurses' Health Study, a cohort of 121,700 US women aged 30-55 years at study inception in 1976. Fasting plasma proinsulin, specific insulin and C-peptide levels were determined in 183 women with a new diagnosis of diabetes made after blood sampling between 1989 and 1990, and 369 control subjects without diabetes.

RESULTS

After adjustment for age, body mass index, family history of diabetes and other potential confounders, including HbA1c, the odds ratios for diabetes associated with increasing quartiles of proinsulin were 1.00, 0.85, 2.49 and 5.73 (P for trend: < 0.001). Proinsulin remained significantly associated with diabetes risk after adjusting for C-peptide and specific insulin (multivariate odds ratios for quartiles: 1.00, 0.78, 1.94, 3.69; P for trend = 0.001). In addition, the proinsulin/insulin ratio was significantly associated with diabetes risk, controlling in multivariate analysis for C-peptide (odds ratios for extreme quartiles: 2.48; 95% CI: 1.14-5.41; P for trend = 0.005).

CONCLUSIONS

These data suggest that proinsulin and the proinsulin/insulin ratio are strong independent predictors of diabetes risk, after adjustment for obesity and other potential confounders.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. mschulze@mail.dife.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16108846

Citation

Schulze, M B., et al. "Hyperproinsulinaemia and Risk of Type 2 Diabetes Mellitus in Women." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 22, no. 9, 2005, pp. 1178-84.
Schulze MB, Solomon CG, Rifai N, et al. Hyperproinsulinaemia and risk of Type 2 diabetes mellitus in women. Diabet Med. 2005;22(9):1178-84.
Schulze, M. B., Solomon, C. G., Rifai, N., Cohen, R. M., Sparrow, J., Hu, F. B., & Manson, J. E. (2005). Hyperproinsulinaemia and risk of Type 2 diabetes mellitus in women. Diabetic Medicine : a Journal of the British Diabetic Association, 22(9), pp. 1178-84.
Schulze MB, et al. Hyperproinsulinaemia and Risk of Type 2 Diabetes Mellitus in Women. Diabet Med. 2005;22(9):1178-84. PubMed PMID: 16108846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperproinsulinaemia and risk of Type 2 diabetes mellitus in women. AU - Schulze,M B, AU - Solomon,C G, AU - Rifai,N, AU - Cohen,R M, AU - Sparrow,J, AU - Hu,F B, AU - Manson,J E, PY - 2005/8/20/pubmed PY - 2005/12/20/medline PY - 2005/8/20/entrez SP - 1178 EP - 84 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 22 IS - 9 N2 - AIMS: Our objective was to examine prospectively the associations between fasting plasma proinsulin and the proinsulin/insulin ratio and the incidence of Type 2 diabetes in women. SUBJECTS AND METHODS: We designed a nested case-control study within the Nurses' Health Study, a cohort of 121,700 US women aged 30-55 years at study inception in 1976. Fasting plasma proinsulin, specific insulin and C-peptide levels were determined in 183 women with a new diagnosis of diabetes made after blood sampling between 1989 and 1990, and 369 control subjects without diabetes. RESULTS: After adjustment for age, body mass index, family history of diabetes and other potential confounders, including HbA1c, the odds ratios for diabetes associated with increasing quartiles of proinsulin were 1.00, 0.85, 2.49 and 5.73 (P for trend: < 0.001). Proinsulin remained significantly associated with diabetes risk after adjusting for C-peptide and specific insulin (multivariate odds ratios for quartiles: 1.00, 0.78, 1.94, 3.69; P for trend = 0.001). In addition, the proinsulin/insulin ratio was significantly associated with diabetes risk, controlling in multivariate analysis for C-peptide (odds ratios for extreme quartiles: 2.48; 95% CI: 1.14-5.41; P for trend = 0.005). CONCLUSIONS: These data suggest that proinsulin and the proinsulin/insulin ratio are strong independent predictors of diabetes risk, after adjustment for obesity and other potential confounders. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/16108846/Hyperproinsulinaemia_and_risk_of_Type_2_diabetes_mellitus_in_women_ L2 - https://doi.org/10.1111/j.1464-5491.2005.01585.x DB - PRIME DP - Unbound Medicine ER -