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Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study.
J Child Psychol Psychiatry. 2005 Sep; 46(9):963-71.JC

Abstract

BACKGROUND

The etiology of autism is unknown. A strong genetic component has been detected but non-genetic factors may also be involved in the etiology.

METHODS

We used data from the Danish Psychiatric Central Register and the Danish Civil Registration System to study some risk factors of autism, including place of birth, parental place of birth, parental age, family history of psychiatric disorders, and paternal identity.

RESULTS

A total of 943,664 children younger than ten years were followed from 1994 to 2001; of those, 818 children developed autism. The highest risks of autism were found in siblings of children with autism, or Asperger's syndrome and other pervasive developmental disorders (PDDs), with relative risks of 22 and 13, respectively. The relative risk of autism in the child was about twice as high if the mother had been diagnosed with a psychiatric disorder. The risk of autism was associated with increasing degree of urbanisation of the child's place of birth and with increasing paternal, but not maternal, age. An increased relative risk of 1.4 was found if the mother was born outside Europe, and in children of parents who were born in different countries.

CONCLUSIONS

The highest risk of autism was found in families with a history of autism, or Asperger's syndrome and other PDDs in siblings, supporting the commonly accepted knowledge that genetic factors are involved in the etiology of autism.

Authors+Show Affiliations

Centre for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Denmark. mbl@psykiatri.aaa.dkNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16108999

Citation

Lauritsen, Marlene Briciet, et al. "Effects of Familial Risk Factors and Place of Birth On the Risk of Autism: a Nationwide Register-based Study." Journal of Child Psychology and Psychiatry, and Allied Disciplines, vol. 46, no. 9, 2005, pp. 963-71.
Lauritsen MB, Pedersen CB, Mortensen PB. Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study. J Child Psychol Psychiatry. 2005;46(9):963-71.
Lauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2005). Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 46(9), 963-71.
Lauritsen MB, Pedersen CB, Mortensen PB. Effects of Familial Risk Factors and Place of Birth On the Risk of Autism: a Nationwide Register-based Study. J Child Psychol Psychiatry. 2005;46(9):963-71. PubMed PMID: 16108999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study. AU - Lauritsen,Marlene Briciet, AU - Pedersen,Carsten Bøcker, AU - Mortensen,Preben Bo, PY - 2005/8/20/pubmed PY - 2005/12/24/medline PY - 2005/8/20/entrez SP - 963 EP - 71 JF - Journal of child psychology and psychiatry, and allied disciplines JO - J Child Psychol Psychiatry VL - 46 IS - 9 N2 - BACKGROUND: The etiology of autism is unknown. A strong genetic component has been detected but non-genetic factors may also be involved in the etiology. METHODS: We used data from the Danish Psychiatric Central Register and the Danish Civil Registration System to study some risk factors of autism, including place of birth, parental place of birth, parental age, family history of psychiatric disorders, and paternal identity. RESULTS: A total of 943,664 children younger than ten years were followed from 1994 to 2001; of those, 818 children developed autism. The highest risks of autism were found in siblings of children with autism, or Asperger's syndrome and other pervasive developmental disorders (PDDs), with relative risks of 22 and 13, respectively. The relative risk of autism in the child was about twice as high if the mother had been diagnosed with a psychiatric disorder. The risk of autism was associated with increasing degree of urbanisation of the child's place of birth and with increasing paternal, but not maternal, age. An increased relative risk of 1.4 was found if the mother was born outside Europe, and in children of parents who were born in different countries. CONCLUSIONS: The highest risk of autism was found in families with a history of autism, or Asperger's syndrome and other PDDs in siblings, supporting the commonly accepted knowledge that genetic factors are involved in the etiology of autism. SN - 0021-9630 UR - https://www.unboundmedicine.com/medline/citation/16108999/Effects_of_familial_risk_factors_and_place_of_birth_on_the_risk_of_autism:_a_nationwide_register_based_study_ L2 - https://doi.org/10.1111/j.1469-7610.2004.00391.x DB - PRIME DP - Unbound Medicine ER -