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Development of novel interpenetrating network gellan gum-poly(vinyl alcohol) hydrogel microspheres for the controlled release of carvedilol.
Drug Dev Ind Pharm. 2005 Jul; 31(6):491-503.DD

Abstract

Novel interpenetrating polymeric network microspheres of gellan gum and poly(vinyl alcohol) were prepared by the emulsion cross-linking method. Carvedilol, an antihypertensive drug, was successfully loaded into these microspheres prepared by changing the experimental variables such as ratio of gellan gum:poly(vinyl alcohol) and extent of cross-linking in order to optimize the process variables on drug encapsulation efficiency, release rates, size, and morphology of the microspheres. Formation of interpenetrating network and the chemical stability of carvedilol after preparing the microspheres was confirmed by Fourier transform infrared spectroscopy. Differential scanning calorimetry and x-ray diffraction studies were made on the drug-loaded microspheres to investigate the crystalline nature of the drug after encapsulation. Results indicated a crystalline dispersion of carvedilol in the polymer matrix. Scanning electron microscopy confirmed the spherical nature and smooth surface morphology of the microspheres produced. Mean particle size of the microspheres as measured by laser light scattering technique ranged between 230 and 346 microm. Carvedilol was successfully encapsulated up to 87% in the polymeric matrices. In vitro release studies were performed in the simulated gastric fluid or simulated intestinal fluid. The release of carvedilol was continued up to 12 h. Dynamic swelling studies were performed in the simulated gastric fluid or simulated intestinal fluid, and diffusion coefficients were calculated by considering the spherical geometry of the matrices. The release data were fitted to an empirical relation to estimate the transport parameters. The mechanical properties of interpenetrating polymeric networks prepared were investigated. Network parameters such as molar mass between cross-links and cross-linking density for interpenetrating polymeric networks were calculated.

Authors+Show Affiliations

Drug Delivery Division, Center of Excellence in Polymer Science, Karnatak University, Dharwad, India.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16109622

Citation

Agnihotri, Sunil A., and Tejraj M. Aminabhavi. "Development of Novel Interpenetrating Network Gellan Gum-poly(vinyl Alcohol) Hydrogel Microspheres for the Controlled Release of Carvedilol." Drug Development and Industrial Pharmacy, vol. 31, no. 6, 2005, pp. 491-503.
Agnihotri SA, Aminabhavi TM. Development of novel interpenetrating network gellan gum-poly(vinyl alcohol) hydrogel microspheres for the controlled release of carvedilol. Drug Dev Ind Pharm. 2005;31(6):491-503.
Agnihotri, S. A., & Aminabhavi, T. M. (2005). Development of novel interpenetrating network gellan gum-poly(vinyl alcohol) hydrogel microspheres for the controlled release of carvedilol. Drug Development and Industrial Pharmacy, 31(6), 491-503.
Agnihotri SA, Aminabhavi TM. Development of Novel Interpenetrating Network Gellan Gum-poly(vinyl Alcohol) Hydrogel Microspheres for the Controlled Release of Carvedilol. Drug Dev Ind Pharm. 2005;31(6):491-503. PubMed PMID: 16109622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of novel interpenetrating network gellan gum-poly(vinyl alcohol) hydrogel microspheres for the controlled release of carvedilol. AU - Agnihotri,Sunil A, AU - Aminabhavi,Tejraj M, PY - 2005/8/20/pubmed PY - 2006/6/21/medline PY - 2005/8/20/entrez SP - 491 EP - 503 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 31 IS - 6 N2 - Novel interpenetrating polymeric network microspheres of gellan gum and poly(vinyl alcohol) were prepared by the emulsion cross-linking method. Carvedilol, an antihypertensive drug, was successfully loaded into these microspheres prepared by changing the experimental variables such as ratio of gellan gum:poly(vinyl alcohol) and extent of cross-linking in order to optimize the process variables on drug encapsulation efficiency, release rates, size, and morphology of the microspheres. Formation of interpenetrating network and the chemical stability of carvedilol after preparing the microspheres was confirmed by Fourier transform infrared spectroscopy. Differential scanning calorimetry and x-ray diffraction studies were made on the drug-loaded microspheres to investigate the crystalline nature of the drug after encapsulation. Results indicated a crystalline dispersion of carvedilol in the polymer matrix. Scanning electron microscopy confirmed the spherical nature and smooth surface morphology of the microspheres produced. Mean particle size of the microspheres as measured by laser light scattering technique ranged between 230 and 346 microm. Carvedilol was successfully encapsulated up to 87% in the polymeric matrices. In vitro release studies were performed in the simulated gastric fluid or simulated intestinal fluid. The release of carvedilol was continued up to 12 h. Dynamic swelling studies were performed in the simulated gastric fluid or simulated intestinal fluid, and diffusion coefficients were calculated by considering the spherical geometry of the matrices. The release data were fitted to an empirical relation to estimate the transport parameters. The mechanical properties of interpenetrating polymeric networks prepared were investigated. Network parameters such as molar mass between cross-links and cross-linking density for interpenetrating polymeric networks were calculated. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/16109622/Development_of_novel_interpenetrating_network_gellan_gum_poly_vinyl_alcohol__hydrogel_microspheres_for_the_controlled_release_of_carvedilol_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639040500215875 DB - PRIME DP - Unbound Medicine ER -