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Investigator ratings of ADHD symptoms during a randomized, placebo-controlled trial of atomoxetine: a comparison of parents and teachers as informants.
J Atten Disord. 2005 May; 8(4):153-9.JA

Abstract

This study compared investigator ratings of ADHD symptoms based on interviews with parents and teachers during a doubleblind, placebo-controlled study of atomoxetine. Investigators completed the ADHD Rating Scale: Investigator (ADHDRS-I) based on separate semistructured interviews with the primary caretaker and teacher of the participant. Interviews were conducted at Visits 2 to 7 during a double-blind treatment protocol comparing atomoxetine (N= 10) and placebo (N= 6). Both parent and teacher-based ratings were sensitive to change in ADHD symptoms with atomoxetine treatment. Parent-based assessment differentiated significantly between treatment with atomoxetine and placebo, whereas teacher-based assessment was less sensitive to change. Parents and teachers showed good agreement on change in ADHDRS-I scores. Investigator ratings based on parent- and teacher-report were sensitive to change in symptoms of ADHD during treatment with atomoxetine. Despite good agreement between parent- and teacher-based ratings of symptom change, parent-based ADHD symptom ratings are more sensitive to symptom change.

Authors+Show Affiliations

Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16110045

Citation

Bohnstedt, Bradley N., et al. "Investigator Ratings of ADHD Symptoms During a Randomized, Placebo-controlled Trial of Atomoxetine: a Comparison of Parents and Teachers as Informants." Journal of Attention Disorders, vol. 8, no. 4, 2005, pp. 153-9.
Bohnstedt BN, Kronenberger WG, Dunn DW, et al. Investigator ratings of ADHD symptoms during a randomized, placebo-controlled trial of atomoxetine: a comparison of parents and teachers as informants. J Atten Disord. 2005;8(4):153-9.
Bohnstedt, B. N., Kronenberger, W. G., Dunn, D. W., Giauque, A. L., Wood, E. A., Rembusch, M. E., & Lafata, D. (2005). Investigator ratings of ADHD symptoms during a randomized, placebo-controlled trial of atomoxetine: a comparison of parents and teachers as informants. Journal of Attention Disorders, 8(4), 153-9.
Bohnstedt BN, et al. Investigator Ratings of ADHD Symptoms During a Randomized, Placebo-controlled Trial of Atomoxetine: a Comparison of Parents and Teachers as Informants. J Atten Disord. 2005;8(4):153-9. PubMed PMID: 16110045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigator ratings of ADHD symptoms during a randomized, placebo-controlled trial of atomoxetine: a comparison of parents and teachers as informants. AU - Bohnstedt,Bradley N, AU - Kronenberger,William G, AU - Dunn,David W, AU - Giauque,Ann L, AU - Wood,Elisabeth A, AU - Rembusch,Mary E, AU - Lafata,Deborah, PY - 2005/8/20/pubmed PY - 2006/1/13/medline PY - 2005/8/20/entrez SP - 153 EP - 9 JF - Journal of attention disorders JO - J Atten Disord VL - 8 IS - 4 N2 - This study compared investigator ratings of ADHD symptoms based on interviews with parents and teachers during a doubleblind, placebo-controlled study of atomoxetine. Investigators completed the ADHD Rating Scale: Investigator (ADHDRS-I) based on separate semistructured interviews with the primary caretaker and teacher of the participant. Interviews were conducted at Visits 2 to 7 during a double-blind treatment protocol comparing atomoxetine (N= 10) and placebo (N= 6). Both parent and teacher-based ratings were sensitive to change in ADHD symptoms with atomoxetine treatment. Parent-based assessment differentiated significantly between treatment with atomoxetine and placebo, whereas teacher-based assessment was less sensitive to change. Parents and teachers showed good agreement on change in ADHDRS-I scores. Investigator ratings based on parent- and teacher-report were sensitive to change in symptoms of ADHD during treatment with atomoxetine. Despite good agreement between parent- and teacher-based ratings of symptom change, parent-based ADHD symptom ratings are more sensitive to symptom change. SN - 1087-0547 UR - https://www.unboundmedicine.com/medline/citation/16110045/Investigator_ratings_of_ADHD_symptoms_during_a_randomized_placebo_controlled_trial_of_atomoxetine:_a_comparison_of_parents_and_teachers_as_informants_ L2 - https://journals.sagepub.com/doi/10.1177/1087054705278797?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -