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The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population.
Mol Vis. 2005 Aug 12; 11:609-12.MV

Abstract

PURPOSE

To assess whether genetic polymorphisms of the apolipoprotein E (APOE) gene are associated with open angle glaucoma (OAG) in the Japanese population.

METHODS

Genomic DNA was examined in a cohort of 310 Japanese patients with OAG and 179 control subjects. The average age was 63.5+/-14.4 years (mean+/-SD) for the OAG patients and 65.5+/-11.6 years for the control subjects. The presence or absence of OAG in patients and controls was based on clinical examination and/or ophthalmic records. The APOE allele frequency (epsilon2, epsilon3, and epsilon4 alleles) was studied by restriction fragment length polymorphism, and compared between OAG patients and control subjects. The association between the intraocular pressure (IOP) and the APOE alleles was also evaluated.

RESULTS

There was a significant difference in the APOE genotype frequencies between these groups (p=0.0006 chi2 test). The frequencies of the epsilon2 and epsilon4 alleles were significantly lower in the OAG patients (epsilon2: 2.6%; epsilon4: 6.0%) compared to the control subjects (epsilon2: 5.0%, p=0.048; epsilon4: 10.6%, p=0.012; Fisher's exact test). The frequency of the epsilon3 allele was significantly higher in the OAG patients (91.4%) compared to the control subjects (84.4%, p=0.0010; Fisher's exact test). Adjusted for age, gender, and IOP, an appropriate three fold reduction in OAG risk (odds ratio [OR] 0.29, 95% confidence interval [CI] 0.10 to 0.80; p=0.018) was found with the epsilon2 allele and a two fold increased risk of OAG (OR 1.97, 95% CI 1.06 to 3.67; p=0.033) was found with the epsilon3 allele. The maximum IOP (18.3+/-6.0 mm Hg) in patients with the epsilon4 allele was significantly lower than that (21.3+/-9.1 mm Hg) in patients without the epsilon4 allele (p=0.006, Student's t-test).

CONCLUSIONS

The APOE gene polymorphism is associated with OAG in the Japanese population. Further studies in the other ethnic populations should be performed to elucidate the relationship between APOE and OAG.

Authors+Show Affiliations

Mabuchi F
Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan. fmabuchi@yamanashi.ac.jp
Tang S
No affiliation info available
Ando D
No affiliation info available
Yamakita M
No affiliation info available
Wang J
No affiliation info available
Kashiwagi K
No affiliation info available
Yamagata Z
No affiliation info available
Iijima H
No affiliation info available
Tsukahara S
No affiliation info available

MeSH

AgedApolipoproteins EFemaleGene FrequencyGenotypeGlaucoma, Open-AngleHumansIntraocular PressureJapanMaleMiddle AgedOdds RatioPolymorphism, Genetic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16110302

Citation

Mabuchi, Fumihiko, et al. "The Apolipoprotein E Gene Polymorphism Is Associated With Open Angle Glaucoma in the Japanese Population." Molecular Vision, vol. 11, 2005, pp. 609-12.
Mabuchi F, Tang S, Ando D, et al. The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population. Mol Vis. 2005;11:609-12.
Mabuchi, F., Tang, S., Ando, D., Yamakita, M., Wang, J., Kashiwagi, K., Yamagata, Z., Iijima, H., & Tsukahara, S. (2005). The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population. Molecular Vision, 11, 609-12.
Mabuchi F, et al. The Apolipoprotein E Gene Polymorphism Is Associated With Open Angle Glaucoma in the Japanese Population. Mol Vis. 2005 Aug 12;11:609-12. PubMed PMID: 16110302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population. AU - Mabuchi,Fumihiko, AU - Tang,Sa, AU - Ando,Daisuke, AU - Yamakita,Mitsuya, AU - Wang,Jingyu, AU - Kashiwagi,Kenji, AU - Yamagata,Zentaro, AU - Iijima,Hiroyuki, AU - Tsukahara,Shigeo, Y1 - 2005/08/12/ PY - 2005/8/20/pubmed PY - 2006/4/14/medline PY - 2005/8/20/entrez SP - 609 EP - 12 JF - Molecular vision JO - Mol Vis VL - 11 N2 - PURPOSE: To assess whether genetic polymorphisms of the apolipoprotein E (APOE) gene are associated with open angle glaucoma (OAG) in the Japanese population. METHODS: Genomic DNA was examined in a cohort of 310 Japanese patients with OAG and 179 control subjects. The average age was 63.5+/-14.4 years (mean+/-SD) for the OAG patients and 65.5+/-11.6 years for the control subjects. The presence or absence of OAG in patients and controls was based on clinical examination and/or ophthalmic records. The APOE allele frequency (epsilon2, epsilon3, and epsilon4 alleles) was studied by restriction fragment length polymorphism, and compared between OAG patients and control subjects. The association between the intraocular pressure (IOP) and the APOE alleles was also evaluated. RESULTS: There was a significant difference in the APOE genotype frequencies between these groups (p=0.0006 chi2 test). The frequencies of the epsilon2 and epsilon4 alleles were significantly lower in the OAG patients (epsilon2: 2.6%; epsilon4: 6.0%) compared to the control subjects (epsilon2: 5.0%, p=0.048; epsilon4: 10.6%, p=0.012; Fisher's exact test). The frequency of the epsilon3 allele was significantly higher in the OAG patients (91.4%) compared to the control subjects (84.4%, p=0.0010; Fisher's exact test). Adjusted for age, gender, and IOP, an appropriate three fold reduction in OAG risk (odds ratio [OR] 0.29, 95% confidence interval [CI] 0.10 to 0.80; p=0.018) was found with the epsilon2 allele and a two fold increased risk of OAG (OR 1.97, 95% CI 1.06 to 3.67; p=0.033) was found with the epsilon3 allele. The maximum IOP (18.3+/-6.0 mm Hg) in patients with the epsilon4 allele was significantly lower than that (21.3+/-9.1 mm Hg) in patients without the epsilon4 allele (p=0.006, Student's t-test). CONCLUSIONS: The APOE gene polymorphism is associated with OAG in the Japanese population. Further studies in the other ethnic populations should be performed to elucidate the relationship between APOE and OAG. SN - 1090-0535 UR - https://www.unboundmedicine.com/medline/citation/16110302/The_apolipoprotein_E_gene_polymorphism_is_associated_with_open_angle_glaucoma_in_the_Japanese_population_ DB - PRIME DP - Unbound Medicine ER -