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[Chemical constituents in roots of Polygala fallax and their anti-oxidation activities in vitro].
Zhongguo Zhong Yao Za Zhi. 2005 Jun; 30(11):827-30.ZZ

Abstract

OBJECTIVE

To study the chemical constituents in roots of P. fallax and their anti-oxidation activities in vitro.

METHOD

Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant. The structures were elucidated on the basis of the spectral evidence and the physical and chemical character. The isolated compounds were screened with four anti-oxidation models in vitro.

RESULT

Seven xanthones, 1,7-dihydroxy-2,3-methylenedioxyxanthone (1), 1-methoxy-2,3-methylenedioxyxanthone (2), 3-hydroxy-1,2-dimethoxyxanthone (3), 1,6,7-trihydroxy-2,3-dimethoxyxanthone (4), 7-hydroxy-1-methoxy-2,3-methylenedioxyxanthone (5), 1,3-dihydroxy-2-methoxyxanthone (6) and 1,3,7-trihydroxy-2-methoxyxanthone (7), were isolated from the roots of P. fallax. And compounds 1 - 7 showed different anti-oxidation activities in the different pharmacological models.

CONCLUSION

Compounds 2, 3, 5 and 7 were isolated from this plant for the first time. Xanthones from this plant showed anti-oxidation activities. The pharmacological activities of the pure compounds from this plant were also reported for the first time.

Authors+Show Affiliations

Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100094, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16110862

Citation

Lin, Li-Lin, et al. "[Chemical Constituents in Roots of Polygala Fallax and Their Anti-oxidation Activities in Vitro]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 30, no. 11, 2005, pp. 827-30.
Lin LL, Huang F, Chen SB, et al. [Chemical constituents in roots of Polygala fallax and their anti-oxidation activities in vitro]. Zhongguo Zhong Yao Za Zhi. 2005;30(11):827-30.
Lin, L. L., Huang, F., Chen, S. B., Yang, D. J., Chen, S. L., Yang, J. S., & Xiao, P. G. (2005). [Chemical constituents in roots of Polygala fallax and their anti-oxidation activities in vitro]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 30(11), 827-30.
Lin LL, et al. [Chemical Constituents in Roots of Polygala Fallax and Their Anti-oxidation Activities in Vitro]. Zhongguo Zhong Yao Za Zhi. 2005;30(11):827-30. PubMed PMID: 16110862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Chemical constituents in roots of Polygala fallax and their anti-oxidation activities in vitro]. AU - Lin,Li-Lin, AU - Huang,Feng, AU - Chen,Si-Bao, AU - Yang,Da-Jian, AU - Chen,Shi-Lin, AU - Yang,Jun-Shan, AU - Xiao,Pei-Gen, PY - 2005/8/23/pubmed PY - 2006/6/20/medline PY - 2005/8/23/entrez SP - 827 EP - 30 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 30 IS - 11 N2 - OBJECTIVE: To study the chemical constituents in roots of P. fallax and their anti-oxidation activities in vitro. METHOD: Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant. The structures were elucidated on the basis of the spectral evidence and the physical and chemical character. The isolated compounds were screened with four anti-oxidation models in vitro. RESULT: Seven xanthones, 1,7-dihydroxy-2,3-methylenedioxyxanthone (1), 1-methoxy-2,3-methylenedioxyxanthone (2), 3-hydroxy-1,2-dimethoxyxanthone (3), 1,6,7-trihydroxy-2,3-dimethoxyxanthone (4), 7-hydroxy-1-methoxy-2,3-methylenedioxyxanthone (5), 1,3-dihydroxy-2-methoxyxanthone (6) and 1,3,7-trihydroxy-2-methoxyxanthone (7), were isolated from the roots of P. fallax. And compounds 1 - 7 showed different anti-oxidation activities in the different pharmacological models. CONCLUSION: Compounds 2, 3, 5 and 7 were isolated from this plant for the first time. Xanthones from this plant showed anti-oxidation activities. The pharmacological activities of the pure compounds from this plant were also reported for the first time. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/16110862/[Chemical_constituents_in_roots_of_Polygala_fallax_and_their_anti_oxidation_activities_in_vitro]_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -