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Is there a role for copper in neurodegenerative diseases?
Mol Aspects Med. 2005 Aug-Oct; 26(4-5):405-20.MA

Abstract

Copper is an essential metal in living organisms; thus, the maintenance of adequate copper levels is of vital importance and is highly regulated. Dysfunction of copper metabolism leading to its excess or deficiency results in severe ailments. Two examples of illnesses related to alterations in copper metabolism are Menkes and Wilson diseases. Several proteins are involved in the maintenance of copper homeostasis, including copper transporters and metal chaperones. In the last several years, the beta-amyloid-precursor protein (beta-APP) and the prion protein (PrP(C)), which are related to the neurodegenerative disorders Alzheimer and prion diseases respectively, have been associated with copper metabolism. Both proteins bind copper through copper-binding domains that also have been shown to reduce copper in vitro. Moreover, this ability to reduce copper is associated with a neuroprotective effect exerted by the copper-binding domain of both proteins against copper in vivo. In addition to a functional link between copper and beta-APP or PrP(C), evidence suggests that copper has a role in Alzheimer and prion diseases. Here, we review the evidence that supports both, the role of beta-APP and PrP(C), in copper metabolism and the putative role of copper in neurodegenerative diseases.

Authors+Show Affiliations

Centro de Regulacion Celular y Patología "Joaquin V. Luco" (CRCP), MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16112188

Citation

Cerpa, Waldo, et al. "Is There a Role for Copper in Neurodegenerative Diseases?" Molecular Aspects of Medicine, vol. 26, no. 4-5, 2005, pp. 405-20.
Cerpa W, Varela-Nallar L, Reyes AE, et al. Is there a role for copper in neurodegenerative diseases? Mol Aspects Med. 2005;26(4-5):405-20.
Cerpa, W., Varela-Nallar, L., Reyes, A. E., Minniti, A. N., & Inestrosa, N. C. (2005). Is there a role for copper in neurodegenerative diseases? Molecular Aspects of Medicine, 26(4-5), 405-20.
Cerpa W, et al. Is There a Role for Copper in Neurodegenerative Diseases. Mol Aspects Med. 2005 Aug-Oct;26(4-5):405-20. PubMed PMID: 16112188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there a role for copper in neurodegenerative diseases? AU - Cerpa,Waldo, AU - Varela-Nallar,Lorena, AU - Reyes,Ariel E, AU - Minniti,Alicia N, AU - Inestrosa,Nibaldo C, PY - 2005/8/23/pubmed PY - 2005/11/5/medline PY - 2005/8/23/entrez SP - 405 EP - 20 JF - Molecular aspects of medicine JO - Mol. Aspects Med. VL - 26 IS - 4-5 N2 - Copper is an essential metal in living organisms; thus, the maintenance of adequate copper levels is of vital importance and is highly regulated. Dysfunction of copper metabolism leading to its excess or deficiency results in severe ailments. Two examples of illnesses related to alterations in copper metabolism are Menkes and Wilson diseases. Several proteins are involved in the maintenance of copper homeostasis, including copper transporters and metal chaperones. In the last several years, the beta-amyloid-precursor protein (beta-APP) and the prion protein (PrP(C)), which are related to the neurodegenerative disorders Alzheimer and prion diseases respectively, have been associated with copper metabolism. Both proteins bind copper through copper-binding domains that also have been shown to reduce copper in vitro. Moreover, this ability to reduce copper is associated with a neuroprotective effect exerted by the copper-binding domain of both proteins against copper in vivo. In addition to a functional link between copper and beta-APP or PrP(C), evidence suggests that copper has a role in Alzheimer and prion diseases. Here, we review the evidence that supports both, the role of beta-APP and PrP(C), in copper metabolism and the putative role of copper in neurodegenerative diseases. SN - 0098-2997 UR - https://www.unboundmedicine.com/medline/citation/16112188/Is_there_a_role_for_copper_in_neurodegenerative_diseases L2 - https://linkinghub.elsevier.com/retrieve/pii/S0098-2997(05)00044-0 DB - PRIME DP - Unbound Medicine ER -