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Psychoneuroimmunodermatology of atopic dermatitis: from empiric data to the evolutionary hypothesis.

Abstract

Atopic dermatitis is a pruritic skin disease affecting predominantly young people. There is evidence that psychologic stress constitutes an increased risk for atopy and influences the disease's clinical course. This risk is believed mediated by the effects of stress on neuroimmunoregulation, which in turn modulates the hypersensitivity response and involves immunoglobulin E-mediated inflammation, helper T-cell 2 predominance, and eosinophilia. This article examines theoretic perspectives and other behavioral dimensions, such as maternal caring behavior, infant response to stress, temperament, and the so-called "hygiene hypothesis." The Darwinian framework and the mental scenario are examined. These processes may be akin to the generation of antibodies by the immune system.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Neuroscience, University of Florence, Florence, Italy. spallanti@agora.it

    ,

    Source

    Dermatologic clinics 23:4 2005 Oct pg 695-701

    MeSH

    Dermatitis, Atopic
    Humans
    Neuroimmunomodulation
    Psychoneuroimmunology

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16112446

    Citation

    Pallanti, Stefano, et al. "Psychoneuroimmunodermatology of Atopic Dermatitis: From Empiric Data to the Evolutionary Hypothesis." Dermatologic Clinics, vol. 23, no. 4, 2005, pp. 695-701.
    Pallanti S, Lotti T, Urpe M. Psychoneuroimmunodermatology of atopic dermatitis: from empiric data to the evolutionary hypothesis. Dermatol Clin. 2005;23(4):695-701.
    Pallanti, S., Lotti, T., & Urpe, M. (2005). Psychoneuroimmunodermatology of atopic dermatitis: from empiric data to the evolutionary hypothesis. Dermatologic Clinics, 23(4), pp. 695-701.
    Pallanti S, Lotti T, Urpe M. Psychoneuroimmunodermatology of Atopic Dermatitis: From Empiric Data to the Evolutionary Hypothesis. Dermatol Clin. 2005;23(4):695-701. PubMed PMID: 16112446.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Psychoneuroimmunodermatology of atopic dermatitis: from empiric data to the evolutionary hypothesis. AU - Pallanti,Stefano, AU - Lotti,Torello, AU - Urpe,Mauro, PY - 2005/8/23/pubmed PY - 2005/10/14/medline PY - 2005/8/23/entrez SP - 695 EP - 701 JF - Dermatologic clinics JO - Dermatol Clin VL - 23 IS - 4 N2 - Atopic dermatitis is a pruritic skin disease affecting predominantly young people. There is evidence that psychologic stress constitutes an increased risk for atopy and influences the disease's clinical course. This risk is believed mediated by the effects of stress on neuroimmunoregulation, which in turn modulates the hypersensitivity response and involves immunoglobulin E-mediated inflammation, helper T-cell 2 predominance, and eosinophilia. This article examines theoretic perspectives and other behavioral dimensions, such as maternal caring behavior, infant response to stress, temperament, and the so-called "hygiene hypothesis." The Darwinian framework and the mental scenario are examined. These processes may be akin to the generation of antibodies by the immune system. SN - 0733-8635 UR - https://www.unboundmedicine.com/medline/citation/16112446/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0733-8635(05)00055-0 DB - PRIME DP - Unbound Medicine ER -