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Taurine prevents fructose-diet induced collagen abnormalities in rat skin.
J Diabetes Complications. 2005 Sep-Oct; 19(5):305-11.JD

Abstract

OBJECTIVE

The aim of the study is to investigate the effect of taurine administration on the content and characteristics of skin collagen in high-fructose-fed rats.

RESEARCH DESIGN AND METHODS

Adult male Wistar rats were divided into four groups of six each: a control group (CON) and a taurine-supplemented control group (CON+TAU), a high fructose diet-fed group (FRU), and a taurine supplemented fructose diet-fed group (FRU+TAU). After 30 days, collagen was isolated from the skin, and its physicochemical properties were studied.

RESULTS

Fructose administration caused an accumulation of collagen and extensive cross-linking. This was evidenced by increases in glycation, fluorescence, and peroxidation in collagen samples. The physicochemical properties of collagen, like shrinkage temperature, aldehyde content, solubility pattern, and susceptibility to denaturing agents, were altered in the fructose-fed rats. The sodium dodecyl sulphate-polyacrylamide gel electrophoretic (SDS-PAGE) pattern of collagen from fructose-fed rats showed and elevated beta component of Type I collagen. Simultaneous administration of taurine alleviated these changes.

CONCLUSION

The positive influence of taurine on both collagen content and its properties suggests a potential mechanism for the ability of taurine to delay diabetic complications.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608002, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16112507

Citation

Nandhini, Thirugnanam Anitha, et al. "Taurine Prevents Fructose-diet Induced Collagen Abnormalities in Rat Skin." Journal of Diabetes and Its Complications, vol. 19, no. 5, 2005, pp. 305-11.
Nandhini TA, Thirunavukkarasu V, Ravichandran MK, et al. Taurine prevents fructose-diet induced collagen abnormalities in rat skin. J Diabetes Complications. 2005;19(5):305-11.
Nandhini, T. A., Thirunavukkarasu, V., Ravichandran, M. K., & Anuradha, C. V. (2005). Taurine prevents fructose-diet induced collagen abnormalities in rat skin. Journal of Diabetes and Its Complications, 19(5), 305-11.
Nandhini TA, et al. Taurine Prevents Fructose-diet Induced Collagen Abnormalities in Rat Skin. J Diabetes Complications. 2005 Sep-Oct;19(5):305-11. PubMed PMID: 16112507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Taurine prevents fructose-diet induced collagen abnormalities in rat skin. AU - Nandhini,Thirugnanam Anitha, AU - Thirunavukkarasu,Velusami, AU - Ravichandran,Mambakkam Katchapeswaran, AU - Anuradha,Carani Venkataraman, PY - 2004/08/30/received PY - 2005/01/20/revised PY - 2005/02/02/accepted PY - 2005/8/23/pubmed PY - 2006/9/20/medline PY - 2005/8/23/entrez SP - 305 EP - 11 JF - Journal of diabetes and its complications JO - J Diabetes Complications VL - 19 IS - 5 N2 - OBJECTIVE: The aim of the study is to investigate the effect of taurine administration on the content and characteristics of skin collagen in high-fructose-fed rats. RESEARCH DESIGN AND METHODS: Adult male Wistar rats were divided into four groups of six each: a control group (CON) and a taurine-supplemented control group (CON+TAU), a high fructose diet-fed group (FRU), and a taurine supplemented fructose diet-fed group (FRU+TAU). After 30 days, collagen was isolated from the skin, and its physicochemical properties were studied. RESULTS: Fructose administration caused an accumulation of collagen and extensive cross-linking. This was evidenced by increases in glycation, fluorescence, and peroxidation in collagen samples. The physicochemical properties of collagen, like shrinkage temperature, aldehyde content, solubility pattern, and susceptibility to denaturing agents, were altered in the fructose-fed rats. The sodium dodecyl sulphate-polyacrylamide gel electrophoretic (SDS-PAGE) pattern of collagen from fructose-fed rats showed and elevated beta component of Type I collagen. Simultaneous administration of taurine alleviated these changes. CONCLUSION: The positive influence of taurine on both collagen content and its properties suggests a potential mechanism for the ability of taurine to delay diabetic complications. SN - 1056-8727 UR - https://www.unboundmedicine.com/medline/citation/16112507/Taurine_prevents_fructose_diet_induced_collagen_abnormalities_in_rat_skin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(05)00008-5 DB - PRIME DP - Unbound Medicine ER -