Tags

Type your tag names separated by a space and hit enter

The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids.
Biochem Biophys Res Commun. 2005 Dec 09; 338(1):149-57.BB

Abstract

Resolvins (Rvs) are oxygenated products derived from omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid that carry potent protective bioactions present in resolving inflammatory exudates. Resolvin E1 (RvE1) is biosynthesized in vivo from EPA via transcellular biosynthetic routes during cell-cell interactions, and thus RvE1 is formed in vivo during multicellular responses such as inflammation and microbial infections. RvE1 protects tissues from leukocyte-mediated injury and counterregulates proinflammatory gene expression. These newly identified Rvs may underlie the beneficial actions of omega-3 PUFAs especially in chronic disorders where unresolved inflammation is a key mechanism of pathogenesis. Here, we present an overview of the biosynthesis of RvE1, with a focus on the aspirin-triggered and microbial P450-initiated pathways. The generation of RvE1 and its actions appear to dampen acute leukocyte responses and facilitate the resolution of inflammation.

Authors+Show Affiliations

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16112645

Citation

Arita, Makoto, et al. "The Contributions of Aspirin and Microbial Oxygenase to the Biosynthesis of Anti-inflammatory Resolvins: Novel Oxygenase Products From Omega-3 Polyunsaturated Fatty Acids." Biochemical and Biophysical Research Communications, vol. 338, no. 1, 2005, pp. 149-57.
Arita M, Clish CB, Serhan CN. The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids. Biochem Biophys Res Commun. 2005;338(1):149-57.
Arita, M., Clish, C. B., & Serhan, C. N. (2005). The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids. Biochemical and Biophysical Research Communications, 338(1), 149-57.
Arita M, Clish CB, Serhan CN. The Contributions of Aspirin and Microbial Oxygenase to the Biosynthesis of Anti-inflammatory Resolvins: Novel Oxygenase Products From Omega-3 Polyunsaturated Fatty Acids. Biochem Biophys Res Commun. 2005 Dec 9;338(1):149-57. PubMed PMID: 16112645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids. AU - Arita,Makoto, AU - Clish,Clary B, AU - Serhan,Charles N, Y1 - 2005/08/10/ PY - 2005/07/11/received PY - 2005/07/22/revised PY - 2005/07/30/accepted PY - 2005/8/23/pubmed PY - 2005/12/29/medline PY - 2005/8/23/entrez SP - 149 EP - 57 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 338 IS - 1 N2 - Resolvins (Rvs) are oxygenated products derived from omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid that carry potent protective bioactions present in resolving inflammatory exudates. Resolvin E1 (RvE1) is biosynthesized in vivo from EPA via transcellular biosynthetic routes during cell-cell interactions, and thus RvE1 is formed in vivo during multicellular responses such as inflammation and microbial infections. RvE1 protects tissues from leukocyte-mediated injury and counterregulates proinflammatory gene expression. These newly identified Rvs may underlie the beneficial actions of omega-3 PUFAs especially in chronic disorders where unresolved inflammation is a key mechanism of pathogenesis. Here, we present an overview of the biosynthesis of RvE1, with a focus on the aspirin-triggered and microbial P450-initiated pathways. The generation of RvE1 and its actions appear to dampen acute leukocyte responses and facilitate the resolution of inflammation. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16112645/The_contributions_of_aspirin_and_microbial_oxygenase_to_the_biosynthesis_of_anti_inflammatory_resolvins:_novel_oxygenase_products_from_omega_3_polyunsaturated_fatty_acids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(05)01684-0 DB - PRIME DP - Unbound Medicine ER -