Age related changes in the characteristics of the near pupil response.Vision Res. 2006 Apr; 46(8-9):1393-403.VR
Static and dynamic aspects of the near pupil response were studied in human subjects in the age range when accommodative amplitude steadily declines. Dynamic accommodative and pupillary responses to step stimuli were recorded in 66 subjects (ages: 14-45 years). Exponential fits to data provided amplitude, peak velocity and time constants. Accommodative amplitude decreased linearly with age (p < 0.05). Pupil constriction per diopter of accommodative response increased exponentially with age (p < 0.05). The amplitude of pupil constriction for a 2D stimulus decreased linearly with age (p < 0.05) and for a 5D stimulus did not change with age (p = 0.90). The latency of pupil constriction did not change with age (p = 0.65), while the mean peak velocity decreased linearly with age (p < 0.05). An increase in the amount of pupil constriction per diopter of accommodative response, but not per diopter of stimulus amplitude, suggests that the near effort per se does not increase with age. There is a slight reduction in the speed of near pupil response with age.