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Bone turnover in young hypoestrogenic women on hormonal therapy.
Eur J Obstet Gynecol Reprod Biol. 2006 Feb 01; 124(2):204-6.EJ

Abstract

OBJECTIVE

To compare the biochemical markers of bone turnover in hypoestrogenic women who had been on the standard dosage of Premarin 0.625 mg to that of the age-matched women who were menstruating spontaneously.

STUDY DESIGN

Chinese women between 25 and 40 years of age with a diagnosis of hypoestrogenism who had been on Premarin 0.625 mg daily for more than 1 year were recruited. The control group comprised age- and parity-matched women who had proven ovulation by mid-cycle serum luiteinising hormone surge. Serum osteocalcin and serum pyridinoline crosslink, markers of bone formation and resorption, respectively, were measured by enzyme-linked immunosorbent assays.

RESULTS

Twenty hypoestrogenic Chinese patients with a mean age of 36.2 were recruited as the study group. The same number of controls was recruited. There were no smokers in either group. The body weight, body height and body mass indices were comparable between the two groups. Both biochemical markers of bone metabolism did not differ between the two groups.

CONCLUSION

The average bone turn-over rate in young hypoestrogenic Chinese women on Premarin 0.625 mg/day was similar to that of normal menstruating women.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China. cwcchan@graduate.hku.hkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16112793

Citation

Chan, Carina C W., et al. "Bone Turnover in Young Hypoestrogenic Women On Hormonal Therapy." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 124, no. 2, 2006, pp. 204-6.
Chan CC, Tang OS, Lau WN, et al. Bone turnover in young hypoestrogenic women on hormonal therapy. Eur J Obstet Gynecol Reprod Biol. 2006;124(2):204-6.
Chan, C. C., Tang, O. S., Lau, W. N., & Tang, G. W. (2006). Bone turnover in young hypoestrogenic women on hormonal therapy. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 124(2), 204-6.
Chan CC, et al. Bone Turnover in Young Hypoestrogenic Women On Hormonal Therapy. Eur J Obstet Gynecol Reprod Biol. 2006 Feb 1;124(2):204-6. PubMed PMID: 16112793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone turnover in young hypoestrogenic women on hormonal therapy. AU - Chan,Carina C W, AU - Tang,Oi-Shan, AU - Lau,Winnie N T, AU - Tang,Grace W K, Y1 - 2005/08/22/ PY - 2005/01/24/received PY - 2005/07/02/revised PY - 2005/07/15/accepted PY - 2005/8/23/pubmed PY - 2007/8/24/medline PY - 2005/8/23/entrez SP - 204 EP - 6 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 124 IS - 2 N2 - OBJECTIVE: To compare the biochemical markers of bone turnover in hypoestrogenic women who had been on the standard dosage of Premarin 0.625 mg to that of the age-matched women who were menstruating spontaneously. STUDY DESIGN: Chinese women between 25 and 40 years of age with a diagnosis of hypoestrogenism who had been on Premarin 0.625 mg daily for more than 1 year were recruited. The control group comprised age- and parity-matched women who had proven ovulation by mid-cycle serum luiteinising hormone surge. Serum osteocalcin and serum pyridinoline crosslink, markers of bone formation and resorption, respectively, were measured by enzyme-linked immunosorbent assays. RESULTS: Twenty hypoestrogenic Chinese patients with a mean age of 36.2 were recruited as the study group. The same number of controls was recruited. There were no smokers in either group. The body weight, body height and body mass indices were comparable between the two groups. Both biochemical markers of bone metabolism did not differ between the two groups. CONCLUSION: The average bone turn-over rate in young hypoestrogenic Chinese women on Premarin 0.625 mg/day was similar to that of normal menstruating women. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/16112793/Bone_turnover_in_young_hypoestrogenic_women_on_hormonal_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(05)00392-1 DB - PRIME DP - Unbound Medicine ER -