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Role of viruses in exacerbations of chronic obstructive pulmonary disease.
Proc Am Thorac Soc 2004; 1(2):115-20PA

Abstract

Exacerbations of chronic obstructive pulmonary disease (COPD) are a major cause of morbidity and mortality and hospital admission. Respiratory viral infections, especially rhinoviruses, are a major cause of COPD exacerbations, with upper respiratory tract infections being associated with over 50% of COPD exacerbations. The presence of an upper respiratory tract infection leads to a more severe exacerbation and a longer symptom recovery time at exacerbation. Respiratory viral infections occurring during COPD exacerbations are more likely to lead to hospitalization. Sputum inflammatory markers were found to be higher in those patients with symptoms of a common cold or where rhinovirus was detected at exacerbation, thus suggesting that viral infections lead to greater airway inflammation and thus more severe exacerbations. COPD exacerbations are associated also with systemic inflammatory effects with increases in markers such as plasma fibrinogen and interleukin-6. Respiratory viruses have also been detected when the patients are stable, and this suggests that chronic viral infection may occur. Strategies to prevent viral infection will have a significant effect on the morbidity of COPD and will improve quality of life.

Authors+Show Affiliations

Academic Unit of Respiratory Medicine, St. Bartholomew's and Royal London School of Medicine and Dentistry, Dominion House, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK. j.a.wedzicha@qmul.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16113423

Citation

Wedzicha, Jadwiga A.. "Role of Viruses in Exacerbations of Chronic Obstructive Pulmonary Disease." Proceedings of the American Thoracic Society, vol. 1, no. 2, 2004, pp. 115-20.
Wedzicha JA. Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2004;1(2):115-20.
Wedzicha, J. A. (2004). Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society, 1(2), pp. 115-20.
Wedzicha JA. Role of Viruses in Exacerbations of Chronic Obstructive Pulmonary Disease. Proc Am Thorac Soc. 2004;1(2):115-20. PubMed PMID: 16113423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of viruses in exacerbations of chronic obstructive pulmonary disease. A1 - Wedzicha,Jadwiga A, PY - 2005/8/23/pubmed PY - 2005/9/24/medline PY - 2005/8/23/entrez SP - 115 EP - 20 JF - Proceedings of the American Thoracic Society JO - Proc Am Thorac Soc VL - 1 IS - 2 N2 - Exacerbations of chronic obstructive pulmonary disease (COPD) are a major cause of morbidity and mortality and hospital admission. Respiratory viral infections, especially rhinoviruses, are a major cause of COPD exacerbations, with upper respiratory tract infections being associated with over 50% of COPD exacerbations. The presence of an upper respiratory tract infection leads to a more severe exacerbation and a longer symptom recovery time at exacerbation. Respiratory viral infections occurring during COPD exacerbations are more likely to lead to hospitalization. Sputum inflammatory markers were found to be higher in those patients with symptoms of a common cold or where rhinovirus was detected at exacerbation, thus suggesting that viral infections lead to greater airway inflammation and thus more severe exacerbations. COPD exacerbations are associated also with systemic inflammatory effects with increases in markers such as plasma fibrinogen and interleukin-6. Respiratory viruses have also been detected when the patients are stable, and this suggests that chronic viral infection may occur. Strategies to prevent viral infection will have a significant effect on the morbidity of COPD and will improve quality of life. SN - 1546-3222 UR - https://www.unboundmedicine.com/medline/citation/16113423/Role_of_viruses_in_exacerbations_of_chronic_obstructive_pulmonary_disease_ L2 - https://ClinicalTrials.gov/search/term=16113423 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -