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Hange-koboku-to, a Kampo medicine, modulates cerebral levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline) and DA (dopamine) in mice.
Phytother Res 2005; 19(6):491-5PR

Abstract

Cerebral monoamine systems play important pathogenic roles in various psychiatric and neurologic diseases, such as depression, anxiety and swallowing disturbance. Hange-koboku-to, a Kampo (Japanese herbal) medicine, has been successfully used for the treatment of these disorders. To elucidate the mechanisms underlying its clinical efficacy for these disorders, the effects of Hange-koboku-to (500 mg/kg, p.o.) on the cerebral monoamine systems were examined. Regional levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline), DA (dopamine) and their metabolites in mouse brain were measured using a high-performance liquid chromatography system. Hange-koboku-to increased the 5-HT and NA levels and decreased 5-HIAA (5-hydroxyindole-3-acetic acid), thus decreasing 5-HT and NA turnover (metabolites/monoamine ratio) in the hypothalamus. The levels of DA, DOPAC (3,4-dihydroxyphenylacetic acid) and HVA (4-hydroxy-3-methoxy-phenylacetic acid) were all increased, resulting in a decreased DA turnover in the striatum. Since decreased 5-HT turnover has been observed after administration of various antidepressants, Hange-koboku-to-mediated reduction of 5-HT turnover may be related to the clinical efficacy of this Kampo medicine on certain psychiatric disorders. Furthermore, the beneficial therapeutic effects of Hange-koboku-to on swallowing disturbance may be related to the increased cerebral DA level brought about by this Kampo medicine.

Authors+Show Affiliations

Department of Bioregulatory Function, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16114091

Citation

Kaneko, Akiyo, et al. "Hange-koboku-to, a Kampo Medicine, Modulates Cerebral Levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline) and DA (dopamine) in Mice." Phytotherapy Research : PTR, vol. 19, no. 6, 2005, pp. 491-5.
Kaneko A, Cho S, Hirai K, et al. Hange-koboku-to, a Kampo medicine, modulates cerebral levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline) and DA (dopamine) in mice. Phytother Res. 2005;19(6):491-5.
Kaneko, A., Cho, S., Hirai, K., Okabe, T., Iwasaki, K., Nanba, Y., ... Cyong, J. C. (2005). Hange-koboku-to, a Kampo medicine, modulates cerebral levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline) and DA (dopamine) in mice. Phytotherapy Research : PTR, 19(6), pp. 491-5.
Kaneko A, et al. Hange-koboku-to, a Kampo Medicine, Modulates Cerebral Levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline) and DA (dopamine) in Mice. Phytother Res. 2005;19(6):491-5. PubMed PMID: 16114091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hange-koboku-to, a Kampo medicine, modulates cerebral levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline) and DA (dopamine) in mice. AU - Kaneko,Akiyo, AU - Cho,Shigefumi, AU - Hirai,Koichi, AU - Okabe,Tetsuro, AU - Iwasaki,Koh, AU - Nanba,Yoshio, AU - Ouchi,Yasuyoshi, AU - Cyong,Jong-Chol, PY - 2005/8/23/pubmed PY - 2005/10/21/medline PY - 2005/8/23/entrez SP - 491 EP - 5 JF - Phytotherapy research : PTR JO - Phytother Res VL - 19 IS - 6 N2 - Cerebral monoamine systems play important pathogenic roles in various psychiatric and neurologic diseases, such as depression, anxiety and swallowing disturbance. Hange-koboku-to, a Kampo (Japanese herbal) medicine, has been successfully used for the treatment of these disorders. To elucidate the mechanisms underlying its clinical efficacy for these disorders, the effects of Hange-koboku-to (500 mg/kg, p.o.) on the cerebral monoamine systems were examined. Regional levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline), DA (dopamine) and their metabolites in mouse brain were measured using a high-performance liquid chromatography system. Hange-koboku-to increased the 5-HT and NA levels and decreased 5-HIAA (5-hydroxyindole-3-acetic acid), thus decreasing 5-HT and NA turnover (metabolites/monoamine ratio) in the hypothalamus. The levels of DA, DOPAC (3,4-dihydroxyphenylacetic acid) and HVA (4-hydroxy-3-methoxy-phenylacetic acid) were all increased, resulting in a decreased DA turnover in the striatum. Since decreased 5-HT turnover has been observed after administration of various antidepressants, Hange-koboku-to-mediated reduction of 5-HT turnover may be related to the clinical efficacy of this Kampo medicine on certain psychiatric disorders. Furthermore, the beneficial therapeutic effects of Hange-koboku-to on swallowing disturbance may be related to the increased cerebral DA level brought about by this Kampo medicine. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/16114091/Hange_koboku_to_a_Kampo_medicine_modulates_cerebral_levels_of_5_HT__5_hydroxytryptamine__NA__noradrenaline__and_DA__dopamine__in_mice_ L2 - https://doi.org/10.1002/ptr.1669 DB - PRIME DP - Unbound Medicine ER -