Tags

Type your tag names separated by a space and hit enter

Stimulative and sedative effects of essential oils upon inhalation in mice.
Arch Pharm Res. 2005 Jul; 28(7):770-4.AP

Abstract

This study investigated the stimulative or sedative effects of inhaling fragrant essential oils (EOs) by using a forced swimming test (FST) with mice. This behavioral test is commonly used to measure the effects of antidepressant drugs. The inhalation by mice of EOs, such as ginger oil (p<0.05), thyme oil (p<0.05), peppermint oil (p<0.05), and cypress oil (p<0.01) resulted in 5% to 22% reduction of immobility. The same results were achieved when over-agitation was artificially induced in the mice by an intraperitoneal injection of caffeine (a psycho-stimulant). In contrast, inhalation of some EOs by the mice resulted in increased immobility. To evaluate more correctly the sedative effects of EOs, the immobility of over-agitated mice induced with caffeine was ascertained after the inhalation of various EOs. Inhalation of lavender oil (p<0.01) and hyssop oil (p<0.01) increased the immobile state in mice that were treated with caffeine. The results of this study indicate that the inhalation of essential oils may induce stimulative or sedative effects in mice.

Authors+Show Affiliations

R&D Center, Hanbul Cosmetics Co. Ltd., 72-7 Yongsung-ri, Samsung-Myun, Chungbuk 369-830, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16114490

Citation

Lim, Won Churl, et al. "Stimulative and Sedative Effects of Essential Oils Upon Inhalation in Mice." Archives of Pharmacal Research, vol. 28, no. 7, 2005, pp. 770-4.
Lim WC, Seo JM, Lee CI, et al. Stimulative and sedative effects of essential oils upon inhalation in mice. Arch Pharm Res. 2005;28(7):770-4.
Lim, W. C., Seo, J. M., Lee, C. I., Pyo, H. B., & Lee, B. C. (2005). Stimulative and sedative effects of essential oils upon inhalation in mice. Archives of Pharmacal Research, 28(7), 770-4.
Lim WC, et al. Stimulative and Sedative Effects of Essential Oils Upon Inhalation in Mice. Arch Pharm Res. 2005;28(7):770-4. PubMed PMID: 16114490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stimulative and sedative effects of essential oils upon inhalation in mice. AU - Lim,Won Churl, AU - Seo,Jeong Min, AU - Lee,Chun Il, AU - Pyo,Hyeong Bae, AU - Lee,Bum Chun, PY - 2005/8/24/pubmed PY - 2006/6/10/medline PY - 2005/8/24/entrez SP - 770 EP - 4 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 28 IS - 7 N2 - This study investigated the stimulative or sedative effects of inhaling fragrant essential oils (EOs) by using a forced swimming test (FST) with mice. This behavioral test is commonly used to measure the effects of antidepressant drugs. The inhalation by mice of EOs, such as ginger oil (p<0.05), thyme oil (p<0.05), peppermint oil (p<0.05), and cypress oil (p<0.01) resulted in 5% to 22% reduction of immobility. The same results were achieved when over-agitation was artificially induced in the mice by an intraperitoneal injection of caffeine (a psycho-stimulant). In contrast, inhalation of some EOs by the mice resulted in increased immobility. To evaluate more correctly the sedative effects of EOs, the immobility of over-agitated mice induced with caffeine was ascertained after the inhalation of various EOs. Inhalation of lavender oil (p<0.01) and hyssop oil (p<0.01) increased the immobile state in mice that were treated with caffeine. The results of this study indicate that the inhalation of essential oils may induce stimulative or sedative effects in mice. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/16114490/Stimulative_and_sedative_effects_of_essential_oils_upon_inhalation_in_mice_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=16114490.ui DB - PRIME DP - Unbound Medicine ER -