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The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients.
Br J Nutr 2005; 94(1):19-26BJ

Abstract

Enhancement of depressed plasma concentrations of glutamine and arginine is associated with better clinical outcome. Supplementation of glutamine might be a way to provide the patient with glutamine, and also arginine, because glutamine provides the kidney with citrulline, from which the kidney produces arginine when plasma levels of arginine are low. The aim of the present study was to investigate the parenteral and enteral response of the administered dipeptide Ala-Gln, glutamine, citrulline and arginine. Therefore, seven patients received 20 g Ala-Gln, administered over 4 h, parenterally or enterally, on two separate occasions. Arterial blood samples were taken before and during the administration of Ala-Gln. ANOVA and a paired t test were used to test differences (P<0.05). Ala-Gln was undetectable with enteral administration, whereas Ala-Gln remained stable at a plasma concentration of 268 micromol/l throughout parenteral infusion and rapidly decreased towards zero after infusion was stopped. The highest level of glutamine was observed with parenteral infusion of the dipeptide, although enteral infusion also significantly increased plasma levels of glutamine. The highest plasma response of citrulline was observed with the enteral administration of the dipeptide, although parenteral administration also increased plasma levels of citrulline. Plasma arginine increased significantly with parenteral infusion, but not with enteral administration of Ala-Gln. In conclusion, administrations of Ala-Gln, parenteral or enteral, resulted in an increased plasma glutamine response, as compared with baseline. Interestingly, in spite of the high availability of citrulline with enteral administration of the dipeptide, only parenteral infusion of Ala-Gln increased plasma arginine concentration.

Authors+Show Affiliations

Department of Surgery, VU University Medical Centre, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16115328

Citation

Melis, Gerdien C., et al. "The Feeding Route (enteral or Parenteral) Affects the Plasma Response of the Dipetide Ala-Gln and the Amino Acids Glutamine, Citrulline and Arginine, With the Administration of Ala-Gln in Preoperative Patients." The British Journal of Nutrition, vol. 94, no. 1, 2005, pp. 19-26.
Melis GC, Boelens PG, van der Sijp JR, et al. The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients. Br J Nutr. 2005;94(1):19-26.
Melis, G. C., Boelens, P. G., van der Sijp, J. R., Popovici, T., De Bandt, J. P., Cynober, L., & van Leeuwen, P. A. (2005). The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients. The British Journal of Nutrition, 94(1), pp. 19-26.
Melis GC, et al. The Feeding Route (enteral or Parenteral) Affects the Plasma Response of the Dipetide Ala-Gln and the Amino Acids Glutamine, Citrulline and Arginine, With the Administration of Ala-Gln in Preoperative Patients. Br J Nutr. 2005;94(1):19-26. PubMed PMID: 16115328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients. AU - Melis,Gerdien C, AU - Boelens,Petra G, AU - van der Sijp,Joost R M, AU - Popovici,Theodora, AU - De Bandt,Jean-Pascal, AU - Cynober,Luc, AU - van Leeuwen,Paul A M, PY - 2005/8/24/pubmed PY - 2005/10/7/medline PY - 2005/8/24/entrez SP - 19 EP - 26 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 94 IS - 1 N2 - Enhancement of depressed plasma concentrations of glutamine and arginine is associated with better clinical outcome. Supplementation of glutamine might be a way to provide the patient with glutamine, and also arginine, because glutamine provides the kidney with citrulline, from which the kidney produces arginine when plasma levels of arginine are low. The aim of the present study was to investigate the parenteral and enteral response of the administered dipeptide Ala-Gln, glutamine, citrulline and arginine. Therefore, seven patients received 20 g Ala-Gln, administered over 4 h, parenterally or enterally, on two separate occasions. Arterial blood samples were taken before and during the administration of Ala-Gln. ANOVA and a paired t test were used to test differences (P<0.05). Ala-Gln was undetectable with enteral administration, whereas Ala-Gln remained stable at a plasma concentration of 268 micromol/l throughout parenteral infusion and rapidly decreased towards zero after infusion was stopped. The highest level of glutamine was observed with parenteral infusion of the dipeptide, although enteral infusion also significantly increased plasma levels of glutamine. The highest plasma response of citrulline was observed with the enteral administration of the dipeptide, although parenteral administration also increased plasma levels of citrulline. Plasma arginine increased significantly with parenteral infusion, but not with enteral administration of Ala-Gln. In conclusion, administrations of Ala-Gln, parenteral or enteral, resulted in an increased plasma glutamine response, as compared with baseline. Interestingly, in spite of the high availability of citrulline with enteral administration of the dipeptide, only parenteral infusion of Ala-Gln increased plasma arginine concentration. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/16115328/The_feeding_route__enteral_or_parenteral__affects_the_plasma_response_of_the_dipetide_Ala_Gln_and_the_amino_acids_glutamine_citrulline_and_arginine_with_the_administration_of_Ala_Gln_in_preoperative_patients_ L2 - https://www.cambridge.org/core/product/identifier/S0007114505001480/type/journal_article DB - PRIME DP - Unbound Medicine ER -