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Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng.
Acta Pharmacol Sin. 2005 Sep; 26(9):1104-10.AP

Abstract

AIM

The antihyperglycemic effects of the total ginsenosides in Chinese ginseng (TGCG), extracted from leaves and the stem, were evaluated in diabetic C57BL/6J ob/ob mice.

METHODS

Animals received daily intraperitoneal injections of TGCG (100 and 200 mg/kg) or oral administration (150 and 300 mg/kg) for 12 d. Fasting blood glucose levels and body weight were measured after fasting the animals for 4 h. Peripheral glucose use was also measured using an intraperitoneal glucose tolerance test.

RESULTS

In the injection group, a high dose of TGCG (200 mg/kg) significantly lowered the fasting blood glucose levels in ob/ob mice on d 12 (153+/-16 mg/dL vs 203+/-9.8 mg/dL, P<0.01, compared to vehicle-treated group). In the oral group, blood glucose decreased notably with a dose of TGCG (300 mg/kg) on d 12 (169.1+/-12.6 mg/dL vs 211.6+/-13.8 mg/dL, P<0.05, compared to the vehicle-treated group). Glucose tolerance was also improved markedly in ob/ob mice. Furthermore, a significant reduction in bodyweight (P<0.05) was observed after 12 d of TGCG (300 mg/kg) treatment in mice from the oral group.

CONCLUSION

The results indicated that in a diabetic ob/ob mouse model TGCG was endowed with significant anti-hyperglycemic and anti-obesity properties. Therefore, the total ginsenosides extracted from Chinese ginseng leaves and the stem may have some potential for treating diabetes.

Authors+Show Affiliations

Tang Center for Herbal Medicine Research;the Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16115378

Citation

Xie, Jing-tian, et al. "Antihyperglycemic Effects of Total Ginsenosides From Leaves and Stem of Panax Ginseng." Acta Pharmacologica Sinica, vol. 26, no. 9, 2005, pp. 1104-10.
Xie JT, Wang CZ, Wang AB, et al. Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng. Acta Pharmacol Sin. 2005;26(9):1104-10.
Xie, J. T., Wang, C. Z., Wang, A. B., Wu, J., Basila, D., & Yuan, C. S. (2005). Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng. Acta Pharmacologica Sinica, 26(9), 1104-10.
Xie JT, et al. Antihyperglycemic Effects of Total Ginsenosides From Leaves and Stem of Panax Ginseng. Acta Pharmacol Sin. 2005;26(9):1104-10. PubMed PMID: 16115378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng. AU - Xie,Jing-tian, AU - Wang,Chong-zhi, AU - Wang,An-bao, AU - Wu,Jian, AU - Basila,Daniel, AU - Yuan,Chun-su, PY - 2005/8/24/pubmed PY - 2006/11/1/medline PY - 2005/8/24/entrez SP - 1104 EP - 10 JF - Acta pharmacologica Sinica JO - Acta Pharmacol. Sin. VL - 26 IS - 9 N2 - AIM: The antihyperglycemic effects of the total ginsenosides in Chinese ginseng (TGCG), extracted from leaves and the stem, were evaluated in diabetic C57BL/6J ob/ob mice. METHODS: Animals received daily intraperitoneal injections of TGCG (100 and 200 mg/kg) or oral administration (150 and 300 mg/kg) for 12 d. Fasting blood glucose levels and body weight were measured after fasting the animals for 4 h. Peripheral glucose use was also measured using an intraperitoneal glucose tolerance test. RESULTS: In the injection group, a high dose of TGCG (200 mg/kg) significantly lowered the fasting blood glucose levels in ob/ob mice on d 12 (153+/-16 mg/dL vs 203+/-9.8 mg/dL, P<0.01, compared to vehicle-treated group). In the oral group, blood glucose decreased notably with a dose of TGCG (300 mg/kg) on d 12 (169.1+/-12.6 mg/dL vs 211.6+/-13.8 mg/dL, P<0.05, compared to the vehicle-treated group). Glucose tolerance was also improved markedly in ob/ob mice. Furthermore, a significant reduction in bodyweight (P<0.05) was observed after 12 d of TGCG (300 mg/kg) treatment in mice from the oral group. CONCLUSION: The results indicated that in a diabetic ob/ob mouse model TGCG was endowed with significant anti-hyperglycemic and anti-obesity properties. Therefore, the total ginsenosides extracted from Chinese ginseng leaves and the stem may have some potential for treating diabetes. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/16115378/Antihyperglycemic_effects_of_total_ginsenosides_from_leaves_and_stem_of_Panax_ginseng_ L2 - http://dx.doi.org/10.1111/j.1745-7254.2005.00156.x DB - PRIME DP - Unbound Medicine ER -