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Aggregation of vascular risk factors and risk of incident Alzheimer disease.
Neurology 2005; 65(4):545-51Neur

Abstract

BACKGROUND

The prevalence of Alzheimer disease (AD) is increasing in the elderly, and vascular risk factors may increase its risk.

OBJECTIVE

To explore the association of the aggregation of vascular risk factors with AD.

METHODS

The authors followed 1,138 individuals without dementia at baseline (mean age 76.2) for a mean of 5.5 years. The presence of vascular risk factors was related to incident possible and probable AD.

RESULTS

Four risk factors (diabetes, hypertension, heart disease, and current smoking) were associated with a higher risk of AD (p < 0.10) when analyzed individually. The risk of AD increased with the number of risk factors (diabetes + hypertension + heart disease + current smoking). The adjusted hazards ratio of probable AD for the presence of three or more risk factors was 3.4 (95% CI: 1.8, 6.3; p for trend < 0.0001) compared with no risk factors. Diabetes and current smoking were the strongest risk factors in isolation or in clusters, but hypertension and heart disease were also related to a higher risk of AD when clustered with diabetes, smoking, or each other.

CONCLUSIONS

The risk of Alzheimer disease (AD) increased with the number of vascular risk factors. Diabetes and current smoking were the strongest risk factors, but clusters including hypertension and heart disease also increased the risk of AD. These associations are unlikely to be explained by misclassification of the outcome, given strong associations when only probable AD is considered.

Authors+Show Affiliations

Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. jal94@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16116114

Citation

Luchsinger, J A., et al. "Aggregation of Vascular Risk Factors and Risk of Incident Alzheimer Disease." Neurology, vol. 65, no. 4, 2005, pp. 545-51.
Luchsinger JA, Reitz C, Honig LS, et al. Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology. 2005;65(4):545-51.
Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S., & Mayeux, R. (2005). Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology, 65(4), pp. 545-51.
Luchsinger JA, et al. Aggregation of Vascular Risk Factors and Risk of Incident Alzheimer Disease. Neurology. 2005 Aug 23;65(4):545-51. PubMed PMID: 16116114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aggregation of vascular risk factors and risk of incident Alzheimer disease. AU - Luchsinger,J A, AU - Reitz,C, AU - Honig,L S, AU - Tang,M X, AU - Shea,Steven, AU - Mayeux,R, PY - 2005/8/24/pubmed PY - 2006/1/24/medline PY - 2005/8/24/entrez SP - 545 EP - 51 JF - Neurology JO - Neurology VL - 65 IS - 4 N2 - BACKGROUND: The prevalence of Alzheimer disease (AD) is increasing in the elderly, and vascular risk factors may increase its risk. OBJECTIVE: To explore the association of the aggregation of vascular risk factors with AD. METHODS: The authors followed 1,138 individuals without dementia at baseline (mean age 76.2) for a mean of 5.5 years. The presence of vascular risk factors was related to incident possible and probable AD. RESULTS: Four risk factors (diabetes, hypertension, heart disease, and current smoking) were associated with a higher risk of AD (p < 0.10) when analyzed individually. The risk of AD increased with the number of risk factors (diabetes + hypertension + heart disease + current smoking). The adjusted hazards ratio of probable AD for the presence of three or more risk factors was 3.4 (95% CI: 1.8, 6.3; p for trend < 0.0001) compared with no risk factors. Diabetes and current smoking were the strongest risk factors in isolation or in clusters, but hypertension and heart disease were also related to a higher risk of AD when clustered with diabetes, smoking, or each other. CONCLUSIONS: The risk of Alzheimer disease (AD) increased with the number of vascular risk factors. Diabetes and current smoking were the strongest risk factors, but clusters including hypertension and heart disease also increased the risk of AD. These associations are unlikely to be explained by misclassification of the outcome, given strong associations when only probable AD is considered. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16116114/Aggregation_of_vascular_risk_factors_and_risk_of_incident_Alzheimer_disease_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=16116114 DB - PRIME DP - Unbound Medicine ER -