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Investigation of an outbreak of scrub typhus in the himalayan region of India.
Jpn J Infect Dis 2005; 58(4):208-10JJ

Abstract

In Indira Gandhi Medical College, Himachal Pradesh, India, during autumn of 2003 (September-November), more than 100 cases of fever of unknown origin (FUO) were reported with 15 ensuing deaths. In addition to all routine investigations and cultures, the Weil-Felix test was incorporated for the investigation of these cases. Antigen was procured from the Central Research Institute, Kasauli. Forty-six percent (45/96) of the cases demonstrated a > or =1:80 titer of agglutinins against OXK antigen. A team from the National Institute of Communicable Diseases, New Delhi, confirmed the antibodies for scrub typhus in some of the serum samples tested for leptospirosis, dengue fever, and rickettsial infections. Twelve blood samples positive for OXK antigen were sent to the Defense Research Development Establishment, Gwalior, for polymerase chain reaction studies, but none of the samples were positive, as all of the patients were already on broad-spectrum antibiotics and had reported to our hospital after 7-10 days of fever. At our institute, the Weil-Felix test has now been rountinely introduced for the investigation of cases of FUO, and the results until April 2004 (150 cases) revealed the presence of other rickettsial infections prevalent in the region. To evaluate the epidemiology and magnitude of the problem, further prospective studies are required.

Authors+Show Affiliations

Department of Microbiology, Indira Gandhi Medical College and Hospital, Himachal Pradesh, India. dr_anu03@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16116251

Citation

Sharma, Anuradha, et al. "Investigation of an Outbreak of Scrub Typhus in the Himalayan Region of India." Japanese Journal of Infectious Diseases, vol. 58, no. 4, 2005, pp. 208-10.
Sharma A, Mahajan S, Gupta ML, et al. Investigation of an outbreak of scrub typhus in the himalayan region of India. Jpn J Infect Dis. 2005;58(4):208-10.
Sharma, A., Mahajan, S., Gupta, M. L., Kanga, A., & Sharma, V. (2005). Investigation of an outbreak of scrub typhus in the himalayan region of India. Japanese Journal of Infectious Diseases, 58(4), pp. 208-10.
Sharma A, et al. Investigation of an Outbreak of Scrub Typhus in the Himalayan Region of India. Jpn J Infect Dis. 2005;58(4):208-10. PubMed PMID: 16116251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of an outbreak of scrub typhus in the himalayan region of India. AU - Sharma,Anuradha, AU - Mahajan,Sanjay, AU - Gupta,M L, AU - Kanga,Anil, AU - Sharma,Vijay, PY - 2005/8/24/pubmed PY - 2005/10/21/medline PY - 2005/8/24/entrez SP - 208 EP - 10 JF - Japanese journal of infectious diseases JO - Jpn. J. Infect. Dis. VL - 58 IS - 4 N2 - In Indira Gandhi Medical College, Himachal Pradesh, India, during autumn of 2003 (September-November), more than 100 cases of fever of unknown origin (FUO) were reported with 15 ensuing deaths. In addition to all routine investigations and cultures, the Weil-Felix test was incorporated for the investigation of these cases. Antigen was procured from the Central Research Institute, Kasauli. Forty-six percent (45/96) of the cases demonstrated a > or =1:80 titer of agglutinins against OXK antigen. A team from the National Institute of Communicable Diseases, New Delhi, confirmed the antibodies for scrub typhus in some of the serum samples tested for leptospirosis, dengue fever, and rickettsial infections. Twelve blood samples positive for OXK antigen were sent to the Defense Research Development Establishment, Gwalior, for polymerase chain reaction studies, but none of the samples were positive, as all of the patients were already on broad-spectrum antibiotics and had reported to our hospital after 7-10 days of fever. At our institute, the Weil-Felix test has now been rountinely introduced for the investigation of cases of FUO, and the results until April 2004 (150 cases) revealed the presence of other rickettsial infections prevalent in the region. To evaluate the epidemiology and magnitude of the problem, further prospective studies are required. SN - 1344-6304 UR - https://www.unboundmedicine.com/medline/citation/16116251/Investigation_of_an_outbreak_of_scrub_typhus_in_the_himalayan_region_of_India_ L2 - http://www0.nih.go.jp/JJID/58/208.html DB - PRIME DP - Unbound Medicine ER -