Type your tag names separated by a space and hit enter

Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia.

Abstract

The epsilon4 allele of the apolipoprotein E gene (APOE4) has been consistently associated with a greater risk of Alzheimer's disease (AD) as well as an earlier onset of AD. It is possible that APOE4 may also play a role in the etiology of other neurodegenerative disorders, such as Parkinson's disease (PD). APOE genotype, age of onset, disease duration, smoking history, and dementia status were collected for families with PD, yielding 324 Caucasian families with complete information. Logistic regression employing one individual per family and including age of onset and disease duration as covariates demonstrated a significantly increased risk of dementia for those individuals having inherited at least one epsilon4 allele (OR=3.37; P=0.002). Survival analyses also demonstrated a significantly earlier age of onset for those subjects with at least one epsilon4 allele (59.7 years) as compared with those homozygous for the more common epsilon3 allele (62.4 years; P=0.009). Thus, consistent with previous studies, we find evidence that the presence of an epsilon4 allele results in significantly earlier onset of PD and a greater likelihood of dementia. It appears the similarities between PD and AD may be due to an overlap in the diseases' genetic etiology.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, Indiana, USA.

    , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Alleles
    Alzheimer Disease
    Apolipoprotein E4
    Apolipoproteins E
    Female
    Genetic Carrier Screening
    Genotype
    Homozygote
    Humans
    Lewy Body Disease
    Male
    Mental Status Schedule
    Middle Aged
    Neurologic Examination
    Neuropsychological Tests
    Parkinson Disease
    Risk
    Statistics as Topic
    Survival Analysis

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    16116614

    Citation

    Pankratz, Nathan, et al. "Presence of an APOE4 Allele Results in Significantly Earlier Onset of Parkinson's Disease and a Higher Risk With Dementia." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 1, 2006, pp. 45-9.
    Pankratz N, Byder L, Halter C, et al. Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia. Mov Disord. 2006;21(1):45-9.
    Pankratz, N., Byder, L., Halter, C., Rudolph, A., Shults, C. W., Conneally, P. M., ... Nichols, W. C. (2006). Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia. Movement Disorders : Official Journal of the Movement Disorder Society, 21(1), pp. 45-9.
    Pankratz N, et al. Presence of an APOE4 Allele Results in Significantly Earlier Onset of Parkinson's Disease and a Higher Risk With Dementia. Mov Disord. 2006;21(1):45-9. PubMed PMID: 16116614.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia. AU - Pankratz,Nathan, AU - Byder,Lisa, AU - Halter,Cheryl, AU - Rudolph,Alice, AU - Shults,Clifford W, AU - Conneally,P Michael, AU - Foroud,Tatiana, AU - Nichols,William C, PY - 2005/8/24/pubmed PY - 2006/7/4/medline PY - 2005/8/24/entrez SP - 45 EP - 9 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 21 IS - 1 N2 - The epsilon4 allele of the apolipoprotein E gene (APOE4) has been consistently associated with a greater risk of Alzheimer's disease (AD) as well as an earlier onset of AD. It is possible that APOE4 may also play a role in the etiology of other neurodegenerative disorders, such as Parkinson's disease (PD). APOE genotype, age of onset, disease duration, smoking history, and dementia status were collected for families with PD, yielding 324 Caucasian families with complete information. Logistic regression employing one individual per family and including age of onset and disease duration as covariates demonstrated a significantly increased risk of dementia for those individuals having inherited at least one epsilon4 allele (OR=3.37; P=0.002). Survival analyses also demonstrated a significantly earlier age of onset for those subjects with at least one epsilon4 allele (59.7 years) as compared with those homozygous for the more common epsilon3 allele (62.4 years; P=0.009). Thus, consistent with previous studies, we find evidence that the presence of an epsilon4 allele results in significantly earlier onset of PD and a greater likelihood of dementia. It appears the similarities between PD and AD may be due to an overlap in the diseases' genetic etiology. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16116614/Presence_of_an_APOE4_allele_results_in_significantly_earlier_onset_of_Parkinson's_disease_and_a_higher_risk_with_dementia_ L2 - https://doi.org/10.1002/mds.20663 DB - PRIME DP - Unbound Medicine ER -