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Sural/radial nerve amplitude ratio: reference values in healthy subjects.
Muscle Nerve. 2005 Nov; 32(5):613-8.MN

Abstract

The sural/radial nerve amplitude ratio (SRAR) has been proposed as a sensitive indicator of early-stage axonal polyneuropathy. However, previous studies did not take into account the effect of sex differences or different calculating methods. To obtain reference values and information on the variability of the SRAR in daily practice, we measured amplitudes of sural and superficial radial sensory nerve action potentials in 106 healthy adults, correlated them with epidemiological variables, and calculated the SRAR in several ways. Our results show that the SRAR is a robust measure, independent of age, weight, sex, or method of calculation. The use of bilateral measurements is recommended. The cut-off value (5th percentile) of 0.2 in these healthy subjects is much lower than found previously, especially compared to defining cut-off values by comparing patients with matched controls. Further study is needed to establish the clinical value of this SRAR in the early detection of axonal polyneuropathies.

Authors+Show Affiliations

Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Center, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16116641

Citation

Overbeek, Berno U H., et al. "Sural/radial Nerve Amplitude Ratio: Reference Values in Healthy Subjects." Muscle & Nerve, vol. 32, no. 5, 2005, pp. 613-8.
Overbeek BU, van Alfen N, Bor JA, et al. Sural/radial nerve amplitude ratio: reference values in healthy subjects. Muscle Nerve. 2005;32(5):613-8.
Overbeek, B. U., van Alfen, N., Bor, J. A., & Zwarts, M. J. (2005). Sural/radial nerve amplitude ratio: reference values in healthy subjects. Muscle & Nerve, 32(5), 613-8.
Overbeek BU, et al. Sural/radial Nerve Amplitude Ratio: Reference Values in Healthy Subjects. Muscle Nerve. 2005;32(5):613-8. PubMed PMID: 16116641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sural/radial nerve amplitude ratio: reference values in healthy subjects. AU - Overbeek,Berno U H, AU - van Alfen,Nens, AU - Bor,Jose A, AU - Zwarts,Machiel J, PY - 2005/8/24/pubmed PY - 2005/12/13/medline PY - 2005/8/24/entrez SP - 613 EP - 8 JF - Muscle & nerve JO - Muscle Nerve VL - 32 IS - 5 N2 - The sural/radial nerve amplitude ratio (SRAR) has been proposed as a sensitive indicator of early-stage axonal polyneuropathy. However, previous studies did not take into account the effect of sex differences or different calculating methods. To obtain reference values and information on the variability of the SRAR in daily practice, we measured amplitudes of sural and superficial radial sensory nerve action potentials in 106 healthy adults, correlated them with epidemiological variables, and calculated the SRAR in several ways. Our results show that the SRAR is a robust measure, independent of age, weight, sex, or method of calculation. The use of bilateral measurements is recommended. The cut-off value (5th percentile) of 0.2 in these healthy subjects is much lower than found previously, especially compared to defining cut-off values by comparing patients with matched controls. Further study is needed to establish the clinical value of this SRAR in the early detection of axonal polyneuropathies. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/16116641/Sural/radial_nerve_amplitude_ratio:_reference_values_in_healthy_subjects_ L2 - https://doi.org/10.1002/mus.20421 DB - PRIME DP - Unbound Medicine ER -