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[Prevalence, prophylaxis and treatment of Wernicke encephalopathy. Thiamine, how much and how do we give it?].
Rev Med Suisse. 2005 Jun 29; 1(26):1740-4.RM

Abstract

Wernicke's encephalopathy (WE) is an acute neuropsychiatric condition due to thiamine deficiency (vitamin B1) most commonly associated with chronic alcohol abuse. WE is difficult to diagnose because the classical triad of signs (confusion, ataxia and ophthalmoplegia) occurs in only 10% of cases. The presentation is often one of a non-specific confusional state which may easily be attributed to intoxication, alcohol withdrawal or to a concurrent morbidity such as head injury. To improve the outcome, it is important to make a presumptive diagnosis of WE and treat the patients as soon as possible with high-dose parenteral thiamine. Patients with an alcohol problem associated with malnutrition should all be offered a preventive treatment with parenteral thiamine in view of the impaired oral thiamine absorption.

Authors+Show Affiliations

Centre de traitement en alcoologie, Département universitaire de médecine et santé communautaires, CHUV, Mont-Paisible 16, 1011 Lausanne. susanne.meier@chuv.chNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

16117048

Citation

Meier, S, and J-B Daeppen. "[Prevalence, Prophylaxis and Treatment of Wernicke Encephalopathy. Thiamine, How Much and How Do We Give It?]." Revue Medicale Suisse, vol. 1, no. 26, 2005, pp. 1740-4.
Meier S, Daeppen JB. [Prevalence, prophylaxis and treatment of Wernicke encephalopathy. Thiamine, how much and how do we give it?]. Rev Med Suisse. 2005;1(26):1740-4.
Meier, S., & Daeppen, J. B. (2005). [Prevalence, prophylaxis and treatment of Wernicke encephalopathy. Thiamine, how much and how do we give it?]. Revue Medicale Suisse, 1(26), 1740-4.
Meier S, Daeppen JB. [Prevalence, Prophylaxis and Treatment of Wernicke Encephalopathy. Thiamine, How Much and How Do We Give It?]. Rev Med Suisse. 2005 Jun 29;1(26):1740-4. PubMed PMID: 16117048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prevalence, prophylaxis and treatment of Wernicke encephalopathy. Thiamine, how much and how do we give it?]. AU - Meier,S, AU - Daeppen,J-B, PY - 2005/8/25/pubmed PY - 2005/12/13/medline PY - 2005/8/25/entrez SP - 1740 EP - 4 JF - Revue medicale suisse JO - Rev Med Suisse VL - 1 IS - 26 N2 - Wernicke's encephalopathy (WE) is an acute neuropsychiatric condition due to thiamine deficiency (vitamin B1) most commonly associated with chronic alcohol abuse. WE is difficult to diagnose because the classical triad of signs (confusion, ataxia and ophthalmoplegia) occurs in only 10% of cases. The presentation is often one of a non-specific confusional state which may easily be attributed to intoxication, alcohol withdrawal or to a concurrent morbidity such as head injury. To improve the outcome, it is important to make a presumptive diagnosis of WE and treat the patients as soon as possible with high-dose parenteral thiamine. Patients with an alcohol problem associated with malnutrition should all be offered a preventive treatment with parenteral thiamine in view of the impaired oral thiamine absorption. SN - 1660-9379 UR - https://www.unboundmedicine.com/medline/citation/16117048/[Prevalence_prophylaxis_and_treatment_of_Wernicke_encephalopathy__Thiamine_how_much_and_how_do_we_give_it]_ L2 - https://medlineplus.gov/alcoholusedisorderaud.html DB - PRIME DP - Unbound Medicine ER -
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