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Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity.

Abstract

The present study aimed at assessing the protective effect of Indigofera oblongifolia on carbon tetrachloride (CCl4-induced hepatotoxicity. Hepatotoxicity was induced in male Wistar rats using CCl4 (1 mL/day at an interval of 72 hours). CCl4-induced animals were treated with I. oblongifolia at different doses. Hepatoprotection was assessed from activities of marker enzymes in serum and antioxidant status in the liver after an experimental period of 10 days. The activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase were significantly (P < .001) increased in serum of CCl4-induced animals when compared with control animals. Antioxidant status was significantly lowered in CCl4-treated animals with a significant (P < .001) increase in the levels of lipid peroxides [thiobarbituric acid-reactive substances (TBARS)], significantly lower levels of glutathione (GSH), and lowered activities of superoxide dismutase (SOD), catalase (CAT), and GSH peroxidase (GPx). The protective effect of I. oblongifolia was evident from lowering of levels of marker enzymes in serum and maintenance of antioxidant status in the liver as seen from lowered levels of TBARS, increased levels of GSH, and increased activities of SOD, CAT, and GPx. These results show the protective effect of I. oblongifolia and suggest the antioxidant property of the extract.

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Authors+Show Affiliations

,

Department of Biochemistry, University of Madras, Chennai, India.

,

Source

Journal of medicinal food 8:2 2005 pg 261-5

MeSH

Alanine Transaminase
Alkaline Phosphatase
Animals
Antioxidants
Aspartate Aminotransferases
Carbon Tetrachloride
Catalase
Chemical and Drug Induced Liver Injury
Glutathione Peroxidase
Indigofera
L-Lactate Dehydrogenase
Lipid Peroxidation
Liver
Liver Diseases
Male
Plant Extracts
Random Allocation
Rats
Rats, Wistar
Superoxide Dismutase
Thiobarbituric Acid Reactive Substances

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16117622

Citation

Shahjahan, M, et al. "Protective Effect of Indigofera Oblongifolia in CCl4-induced Hepatotoxicity." Journal of Medicinal Food, vol. 8, no. 2, 2005, pp. 261-5.
Shahjahan M, Vani G, Devi CS. Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. J Med Food. 2005;8(2):261-5.
Shahjahan, M., Vani, G., & Devi, C. S. (2005). Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. Journal of Medicinal Food, 8(2), pp. 261-5.
Shahjahan M, Vani G, Devi CS. Protective Effect of Indigofera Oblongifolia in CCl4-induced Hepatotoxicity. J Med Food. 2005;8(2):261-5. PubMed PMID: 16117622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. AU - Shahjahan,M, AU - Vani,G, AU - Devi,C S Shyamala, PY - 2005/8/25/pubmed PY - 2005/11/11/medline PY - 2005/8/25/entrez SP - 261 EP - 5 JF - Journal of medicinal food JO - J Med Food VL - 8 IS - 2 N2 - The present study aimed at assessing the protective effect of Indigofera oblongifolia on carbon tetrachloride (CCl4-induced hepatotoxicity. Hepatotoxicity was induced in male Wistar rats using CCl4 (1 mL/day at an interval of 72 hours). CCl4-induced animals were treated with I. oblongifolia at different doses. Hepatoprotection was assessed from activities of marker enzymes in serum and antioxidant status in the liver after an experimental period of 10 days. The activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase were significantly (P < .001) increased in serum of CCl4-induced animals when compared with control animals. Antioxidant status was significantly lowered in CCl4-treated animals with a significant (P < .001) increase in the levels of lipid peroxides [thiobarbituric acid-reactive substances (TBARS)], significantly lower levels of glutathione (GSH), and lowered activities of superoxide dismutase (SOD), catalase (CAT), and GSH peroxidase (GPx). The protective effect of I. oblongifolia was evident from lowering of levels of marker enzymes in serum and maintenance of antioxidant status in the liver as seen from lowered levels of TBARS, increased levels of GSH, and increased activities of SOD, CAT, and GPx. These results show the protective effect of I. oblongifolia and suggest the antioxidant property of the extract. SN - 1096-620X UR - https://www.unboundmedicine.com/medline/citation/16117622/Protective_effect_of_Indigofera_oblongifolia_in_CCl4_induced_hepatotoxicity_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -