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Increased plasma levels of natriuretic peptide type B and A in children with congenital heart defects with left compared with right ventricular volume overload or pressure overload.
Clin Physiol Funct Imaging. 2005 Sep; 25(5):263-9.CP

Abstract

AIM

Natriuretic peptide levels B (BNP) and A (ANP) have been described in children with congenital heart defects (CHD) with pressure and volume overload. However, the impact of ventricular morphology per se on natriuretic peptide levels has not been reported. The aim of the present study was to evaluate plasma BNP and ANP in children with CHD with left or right ventricular volume or pressure overload.

METHODS AND RESULTS

Plasma BNP and ANP were analysed in 61 children, median age 3.1 (0.3-16.2) years. Haemodynamic load was evaluated by echo-Doppler and/or catheterization measurements and classified as: pressure overload of the right (RV pressure) or left (LV pressure) ventricle, or volume overload of the right (RV volume) or left (LV volume) ventricle, of a sufficient degree to indicate surgery/catheter intervention. Twenty-three children, with a median age of 1.1 (0.1-8.3) years, without heart disease, served as controls for the natriuretic peptide measurements. Children in the LV volume group had significantly higher BNP and ANP values, 55.4 ng l-1 (10.7-352) and 164 (31.8-346), than children in the RV volume, 15.6 (0.0-105.1) and 57.2 (11.3-234.1), LV pressure, 6.8 (0.7-170) and 40.8 (12.6-210), and RV pressure, 18.0 (5.0-29.1) and 69.3 (8.7-182), groups respectively (P<0.0001). The values in the LV pressure group were close to the values in the Control group, 4.7 (0.0-17.7) and 32.9 (11.7-212.1), respectively (P=0.051 and P=0.378, respectively).

CONCLUSIONS

Plasma concentrations of BNP and ANP were higher in children with CHD with left ventricular volume overload compared with right ventricular volume overload or pressure overload.

Authors+Show Affiliations

The Department of Pediatrics, Division of Cardiology, The Queen Silvia Children's Hospital, Göteborg, Sweden. daniel.holmgren@gregion.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16117728

Citation

Holmgren, Daniel, et al. "Increased Plasma Levels of Natriuretic Peptide Type B and a in Children With Congenital Heart Defects With Left Compared With Right Ventricular Volume Overload or Pressure Overload." Clinical Physiology and Functional Imaging, vol. 25, no. 5, 2005, pp. 263-9.
Holmgren D, Westerlind A, Lundberg PA, et al. Increased plasma levels of natriuretic peptide type B and A in children with congenital heart defects with left compared with right ventricular volume overload or pressure overload. Clin Physiol Funct Imaging. 2005;25(5):263-9.
Holmgren, D., Westerlind, A., Lundberg, P. A., & Wåhlander, H. (2005). Increased plasma levels of natriuretic peptide type B and A in children with congenital heart defects with left compared with right ventricular volume overload or pressure overload. Clinical Physiology and Functional Imaging, 25(5), 263-9.
Holmgren D, et al. Increased Plasma Levels of Natriuretic Peptide Type B and a in Children With Congenital Heart Defects With Left Compared With Right Ventricular Volume Overload or Pressure Overload. Clin Physiol Funct Imaging. 2005;25(5):263-9. PubMed PMID: 16117728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased plasma levels of natriuretic peptide type B and A in children with congenital heart defects with left compared with right ventricular volume overload or pressure overload. AU - Holmgren,Daniel, AU - Westerlind,Andreas, AU - Lundberg,Per-Arne, AU - Wåhlander,Håkan, PY - 2005/8/25/pubmed PY - 2006/1/25/medline PY - 2005/8/25/entrez SP - 263 EP - 9 JF - Clinical physiology and functional imaging JO - Clin Physiol Funct Imaging VL - 25 IS - 5 N2 - AIM: Natriuretic peptide levels B (BNP) and A (ANP) have been described in children with congenital heart defects (CHD) with pressure and volume overload. However, the impact of ventricular morphology per se on natriuretic peptide levels has not been reported. The aim of the present study was to evaluate plasma BNP and ANP in children with CHD with left or right ventricular volume or pressure overload. METHODS AND RESULTS: Plasma BNP and ANP were analysed in 61 children, median age 3.1 (0.3-16.2) years. Haemodynamic load was evaluated by echo-Doppler and/or catheterization measurements and classified as: pressure overload of the right (RV pressure) or left (LV pressure) ventricle, or volume overload of the right (RV volume) or left (LV volume) ventricle, of a sufficient degree to indicate surgery/catheter intervention. Twenty-three children, with a median age of 1.1 (0.1-8.3) years, without heart disease, served as controls for the natriuretic peptide measurements. Children in the LV volume group had significantly higher BNP and ANP values, 55.4 ng l-1 (10.7-352) and 164 (31.8-346), than children in the RV volume, 15.6 (0.0-105.1) and 57.2 (11.3-234.1), LV pressure, 6.8 (0.7-170) and 40.8 (12.6-210), and RV pressure, 18.0 (5.0-29.1) and 69.3 (8.7-182), groups respectively (P<0.0001). The values in the LV pressure group were close to the values in the Control group, 4.7 (0.0-17.7) and 32.9 (11.7-212.1), respectively (P=0.051 and P=0.378, respectively). CONCLUSIONS: Plasma concentrations of BNP and ANP were higher in children with CHD with left ventricular volume overload compared with right ventricular volume overload or pressure overload. SN - 1475-0961 UR - https://www.unboundmedicine.com/medline/citation/16117728/Increased_plasma_levels_of_natriuretic_peptide_type_B_and_A_in_children_with_congenital_heart_defects_with_left_compared_with_right_ventricular_volume_overload_or_pressure_overload_ L2 - https://doi.org/10.1111/j.1475-097X.2005.00622.x DB - PRIME DP - Unbound Medicine ER -