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Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population.

Abstract

OBJECTIVE

Adiponectin, resistin, ghrelin and the IGF-I system seem to play an important role in the regulation of body composition throughout life, but the mechanisms are not well understood. The aim of our study was to analyse the distribution among sexes and all decades of the adult life of adiponectin, resistin and ghrelin and their relationship with anthropometric, body composition parameters and the IGF-I system.

SUBJECTS

One hundred and thirty-four men and 127 healthy women were included in the study.

MEASUREMENTS

Plasma concentration of adiponectin, resistin, ghrelin, total IGF-I, free IGF-I and IGFBP-3 were determined in all subjects. Body composition was evaluated by bioelectrical impedance.

RESULTS

Resistin and ghrelin were not affected by age. Plasma adiponectin correlated negatively with age, body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), fat mass (FM) and body fat (BF) in men. Adiponectin correlated negatively with WHR and positively with free IGF-I in women. Resistin correlated positively with BMI and WC only in men, and ghrelin correlated positively with WC, BMI and FM and negatively with free IGF-I in men. In multiple regression analysis adiponectin remained associated with WHR (beta=-0.19, P=0.01) in women. Resistin was positively associated with BMI (beta=0.30, P=0.003) in women and ghrelin was negatively related to free IGF-I (beta=-0.158, P=0.019) in men.

CONCLUSIONS

Plasma adiponectin declines with age and is negatively associated with FM in men. Our data suggest the existence of a positive correlation of adiponectin and the IGF-I axis in women and of an inverse relationship between ghrelin and the IGF-I system in men.

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  • Authors+Show Affiliations

    ,

    Endocrinology and Diabetes Unit, Hospital Universitari de Bellvitge, Barcelona, Spain. nuriavilarrasa@yahoo.es

    , , , , , , , ,

    Source

    Clinical endocrinology 63:3 2005 Sep pg 329-35

    MeSH

    Adiponectin
    Adult
    Aging
    Anthropometry
    Body Composition
    Body Mass Index
    Female
    Ghrelin
    Hormones, Ectopic
    Humans
    Insulin-Like Growth Factor I
    Intercellular Signaling Peptides and Proteins
    Linear Models
    Male
    Middle Aged
    Peptide Hormones
    Reference Values
    Resistin
    Sex Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16117822

    Citation

    Vilarrasa, Nuria, et al. "Distribution and Determinants of Adiponectin, Resistin and Ghrelin in a Randomly Selected Healthy Population." Clinical Endocrinology, vol. 63, no. 3, 2005, pp. 329-35.
    Vilarrasa N, Vendrell J, Maravall J, et al. Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population. Clin Endocrinol (Oxf). 2005;63(3):329-35.
    Vilarrasa, N., Vendrell, J., Maravall, J., Broch, M., Estepa, A., Megia, A., ... Gómez, J. M. (2005). Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population. Clinical Endocrinology, 63(3), pp. 329-35.
    Vilarrasa N, et al. Distribution and Determinants of Adiponectin, Resistin and Ghrelin in a Randomly Selected Healthy Population. Clin Endocrinol (Oxf). 2005;63(3):329-35. PubMed PMID: 16117822.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population. AU - Vilarrasa,Nuria, AU - Vendrell,Joan, AU - Maravall,Javier, AU - Broch,Montse, AU - Estepa,Araceli, AU - Megia,Anna, AU - Soler,Joan, AU - Simón,Inma, AU - Richart,C, AU - Gómez,Jose Manuel, PY - 2005/8/25/pubmed PY - 2005/11/15/medline PY - 2005/8/25/entrez SP - 329 EP - 35 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 63 IS - 3 N2 - OBJECTIVE: Adiponectin, resistin, ghrelin and the IGF-I system seem to play an important role in the regulation of body composition throughout life, but the mechanisms are not well understood. The aim of our study was to analyse the distribution among sexes and all decades of the adult life of adiponectin, resistin and ghrelin and their relationship with anthropometric, body composition parameters and the IGF-I system. SUBJECTS: One hundred and thirty-four men and 127 healthy women were included in the study. MEASUREMENTS: Plasma concentration of adiponectin, resistin, ghrelin, total IGF-I, free IGF-I and IGFBP-3 were determined in all subjects. Body composition was evaluated by bioelectrical impedance. RESULTS: Resistin and ghrelin were not affected by age. Plasma adiponectin correlated negatively with age, body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), fat mass (FM) and body fat (BF) in men. Adiponectin correlated negatively with WHR and positively with free IGF-I in women. Resistin correlated positively with BMI and WC only in men, and ghrelin correlated positively with WC, BMI and FM and negatively with free IGF-I in men. In multiple regression analysis adiponectin remained associated with WHR (beta=-0.19, P=0.01) in women. Resistin was positively associated with BMI (beta=0.30, P=0.003) in women and ghrelin was negatively related to free IGF-I (beta=-0.158, P=0.019) in men. CONCLUSIONS: Plasma adiponectin declines with age and is negatively associated with FM in men. Our data suggest the existence of a positive correlation of adiponectin and the IGF-I axis in women and of an inverse relationship between ghrelin and the IGF-I system in men. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/16117822/Distribution_and_determinants_of_adiponectin_resistin_and_ghrelin_in_a_randomly_selected_healthy_population_ L2 - https://doi.org/10.1111/j.1365-2265.2005.02346.x DB - PRIME DP - Unbound Medicine ER -