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Alcohol consumption and mortality among middle-aged and elderly Japanese men and women.

Abstract

PURPOSE

We conducted a prospective cohort study to examine the association between alcohol intake and the risk of all-cause mortality among middle-aged and elderly Japanese men and women.

METHODS

At baseline (1988-1990), a total of 110,792 Japanese men and women aged 40 to 79 years were asked to complete a questionnaire that included information on alcohol intake, and were followed up for all-cause mortality through December 31, 1999. Relative risks (95% confidence interval) were calculated using Cox proportional-hazards models.

RESULTS

The risk of all-cause mortality was lowest among current drinkers with an alcohol intake of 0.1 to 22.9 g/d (RR, 0.80; 95% CI, 0.72-0.88 for men; and RR, 0.88; 95% CI, 0.77-1.00 for women). Excessive mortality associated with heavy drinking (> or = 69 g/d) was observed for cancer, cardiovascular disease and injuries and other external causes in men, while significantly reduced mortality with light drinking was seen for cancer in men and CVD in women. For men, the benefit associated with light alcohol consumption (< 23 g/d) was more apparent among nonsmokers than among smokers.

CONCLUSION

Our prospective data show a 12% to 20% decreased risk of all-cause mortality in both Japanese men and women who consumed less than 23 g/d of alcohol (approximately 2 drinks), although heavy drinking increased that risk.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan.

    , , , , , , , , ,

    Source

    Annals of epidemiology 15:8 2005 Sep pg 590-7

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Cardiovascular Diseases
    Cohort Studies
    Female
    Health Status
    Humans
    Japan
    Male
    Middle Aged
    Mortality
    Neoplasms
    Proportional Hazards Models
    Smoking
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16118003

    Citation

    Lin, Yingsong, et al. "Alcohol Consumption and Mortality Among Middle-aged and Elderly Japanese Men and Women." Annals of Epidemiology, vol. 15, no. 8, 2005, pp. 590-7.
    Lin Y, Kikuchi S, Tamakoshi A, et al. Alcohol consumption and mortality among middle-aged and elderly Japanese men and women. Ann Epidemiol. 2005;15(8):590-7.
    Lin, Y., Kikuchi, S., Tamakoshi, A., Wakai, K., Kawamura, T., Iso, H., ... Ishibashi, T. (2005). Alcohol consumption and mortality among middle-aged and elderly Japanese men and women. Annals of Epidemiology, 15(8), pp. 590-7.
    Lin Y, et al. Alcohol Consumption and Mortality Among Middle-aged and Elderly Japanese Men and Women. Ann Epidemiol. 2005;15(8):590-7. PubMed PMID: 16118003.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and mortality among middle-aged and elderly Japanese men and women. AU - Lin,Yingsong, AU - Kikuchi,Shogo, AU - Tamakoshi,Akiko, AU - Wakai,Kenji, AU - Kawamura,Takashi, AU - Iso,Hiroyasu, AU - Ogimoto,Itsuro, AU - Yagyu,Kiyoko, AU - Obata,Yuki, AU - Ishibashi,Teruo, AU - ,, Y1 - 2005/01/23/ PY - 2004/07/14/received PY - 2004/10/19/accepted PY - 2005/8/25/pubmed PY - 2006/8/11/medline PY - 2005/8/25/entrez SP - 590 EP - 7 JF - Annals of epidemiology JO - Ann Epidemiol VL - 15 IS - 8 N2 - PURPOSE: We conducted a prospective cohort study to examine the association between alcohol intake and the risk of all-cause mortality among middle-aged and elderly Japanese men and women. METHODS: At baseline (1988-1990), a total of 110,792 Japanese men and women aged 40 to 79 years were asked to complete a questionnaire that included information on alcohol intake, and were followed up for all-cause mortality through December 31, 1999. Relative risks (95% confidence interval) were calculated using Cox proportional-hazards models. RESULTS: The risk of all-cause mortality was lowest among current drinkers with an alcohol intake of 0.1 to 22.9 g/d (RR, 0.80; 95% CI, 0.72-0.88 for men; and RR, 0.88; 95% CI, 0.77-1.00 for women). Excessive mortality associated with heavy drinking (> or = 69 g/d) was observed for cancer, cardiovascular disease and injuries and other external causes in men, while significantly reduced mortality with light drinking was seen for cancer in men and CVD in women. For men, the benefit associated with light alcohol consumption (< 23 g/d) was more apparent among nonsmokers than among smokers. CONCLUSION: Our prospective data show a 12% to 20% decreased risk of all-cause mortality in both Japanese men and women who consumed less than 23 g/d of alcohol (approximately 2 drinks), although heavy drinking increased that risk. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/16118003/Alcohol_consumption_and_mortality_among_middle_aged_and_elderly_Japanese_men_and_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(04)00326-6 DB - PRIME DP - Unbound Medicine ER -