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Risk factors for post-partum complications occurring after preeclampsia and HELLP syndrome. A study in 453 consecutive pregnancies.
Eur J Obstet Gynecol Reprod Biol. 2006 Mar 01; 125(1):59-65.EJ

Abstract

OBJECTIVE

To evaluate complications that occurred during the post-partum period for patients with preeclampsia or HELLP syndrome.

STUDY DESIGN

Retrospective analysis of 453 patients. The main outcome measures were maternal complications during post-partum period: fever >38.5 degrees C with proved infection, abdominal or perineal abscess, thrombo-embolic events, reoperation, need for blood transfusion, acute renal failure, eclampsia or disseminated intravascular coagulation. Statistic tests included univariate and multivariate analysis with stepwise descending logistic regression.

RESULTS

Patients were divided into 305 preeclampsia (67.3%) and 20 HELLP syndrome (4.4%), 128 (28.3%) had both. Eighty-five patients (18.8%) had at least one post-partum complication. The most frequent complication was infection: fever (41 patients, 9.1%) and abscess (30 patients, 6.6%). Twenty-six transfusions (5.7%), 10 disseminated intravascular coagulation (2.2%), seven thromboembolic events (1.5%), seven reoperations (1.5%) and one eclampsia (0.2%) were observed. There was no acute renal failure, no pulmonary oedema and no maternal death. Stepwise logistic regression showed five independent risk factors associated with post-partum complications: ascites or pulmonary oedema (OR: 1.84, 95% CI: 1.01-3.37), platelet count <100000/mm3 (OR: 1.96, 95% CI: 1.18-3.26), serum acid uric >360 micromol/l (OR: 2.36, 95% CI: 1.22-4.52), serum creatinine >120 micromol/l (OR: 2.99, 95% CI: 1.32-6.78), and proteinuria >5 g/l (OR: 1.80, 95% CI: 1.06-3.05).

CONCLUSION

We conclude that severity criteria for preeclampsia or HELLP syndrome combined with caesarean section increased the risk of complication during the post-partum period.

Authors+Show Affiliations

Clinique d'Obstétrique, Hôpital Jeanne de Flandre, CHRU de LILLE, 1 rue Eugène Avinée, 59037 Lille Cedex, France. p-deruelle@chru-lille.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16118033

Citation

Deruelle, Philippe, et al. "Risk Factors for Post-partum Complications Occurring After Preeclampsia and HELLP Syndrome. a Study in 453 Consecutive Pregnancies." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 125, no. 1, 2006, pp. 59-65.
Deruelle P, Coudoux E, Ego A, et al. Risk factors for post-partum complications occurring after preeclampsia and HELLP syndrome. A study in 453 consecutive pregnancies. Eur J Obstet Gynecol Reprod Biol. 2006;125(1):59-65.
Deruelle, P., Coudoux, E., Ego, A., Houfflin-Debarge, V., Codaccioni, X., & Subtil, D. (2006). Risk factors for post-partum complications occurring after preeclampsia and HELLP syndrome. A study in 453 consecutive pregnancies. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 125(1), 59-65.
Deruelle P, et al. Risk Factors for Post-partum Complications Occurring After Preeclampsia and HELLP Syndrome. a Study in 453 Consecutive Pregnancies. Eur J Obstet Gynecol Reprod Biol. 2006 Mar 1;125(1):59-65. PubMed PMID: 16118033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for post-partum complications occurring after preeclampsia and HELLP syndrome. A study in 453 consecutive pregnancies. AU - Deruelle,Philippe, AU - Coudoux,Elodie, AU - Ego,Anne, AU - Houfflin-Debarge,Véronique, AU - Codaccioni,Xavier, AU - Subtil,Damien, Y1 - 2005/08/22/ PY - 2004/08/11/received PY - 2005/04/08/revised PY - 2005/07/17/accepted PY - 2005/8/25/pubmed PY - 2006/8/5/medline PY - 2005/8/25/entrez SP - 59 EP - 65 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 125 IS - 1 N2 - OBJECTIVE: To evaluate complications that occurred during the post-partum period for patients with preeclampsia or HELLP syndrome. STUDY DESIGN: Retrospective analysis of 453 patients. The main outcome measures were maternal complications during post-partum period: fever >38.5 degrees C with proved infection, abdominal or perineal abscess, thrombo-embolic events, reoperation, need for blood transfusion, acute renal failure, eclampsia or disseminated intravascular coagulation. Statistic tests included univariate and multivariate analysis with stepwise descending logistic regression. RESULTS: Patients were divided into 305 preeclampsia (67.3%) and 20 HELLP syndrome (4.4%), 128 (28.3%) had both. Eighty-five patients (18.8%) had at least one post-partum complication. The most frequent complication was infection: fever (41 patients, 9.1%) and abscess (30 patients, 6.6%). Twenty-six transfusions (5.7%), 10 disseminated intravascular coagulation (2.2%), seven thromboembolic events (1.5%), seven reoperations (1.5%) and one eclampsia (0.2%) were observed. There was no acute renal failure, no pulmonary oedema and no maternal death. Stepwise logistic regression showed five independent risk factors associated with post-partum complications: ascites or pulmonary oedema (OR: 1.84, 95% CI: 1.01-3.37), platelet count <100000/mm3 (OR: 1.96, 95% CI: 1.18-3.26), serum acid uric >360 micromol/l (OR: 2.36, 95% CI: 1.22-4.52), serum creatinine >120 micromol/l (OR: 2.99, 95% CI: 1.32-6.78), and proteinuria >5 g/l (OR: 1.80, 95% CI: 1.06-3.05). CONCLUSION: We conclude that severity criteria for preeclampsia or HELLP syndrome combined with caesarean section increased the risk of complication during the post-partum period. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/16118033/Risk_factors_for_post_partum_complications_occurring_after_preeclampsia_and_HELLP_syndrome__A_study_in_453_consecutive_pregnancies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(05)00391-X DB - PRIME DP - Unbound Medicine ER -