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Inhibition of potassium bromate-induced renal oxidative stress and hyperproliferative response by Nymphaea alba in Wistar rats.
J Enzyme Inhib Med Chem. 2005 Jun; 20(3):275-83.JE

Abstract

KBrO3-mediated renal injury and hyperproliferative response in Wistar rats. In this communication, we report the efficacy of Nymphaea alba on KBrO3 (125 mg/kg body weight, intraperitoneally) caused reduction in renal glutathione content, renal antioxidant enzymes and phase-II metabolising enzymes with enhancement in xanthine oxidase, lipid peroxidation, gamma-glutamyl transpeptidase and hydrogen peroxide (H202). It also induced blood urea nitrogen, serum creatinine and tumor promotion markers, viz., ornithine decarboxylase (ODC) activity and DNA synthesis. Treatment of rats with Nymphaea alba (100 and 200 mg/kg body weight) one hour before KBrO3 (125 mg/kg body weight, i.p.) resulted in significant decreases in xanthine oxidase (P < 0.05), lipid peroxidation, gamma-glutamyl transpeptidase, H202 generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Renal glutathione content, glutathione metabolizing enzymes and antioxidant enzymes were also recovered to significant levels (P < 0.001). These results show that Nymphaea alba acts as chemopreventive agent against KBrO3-mediated renal injury and hyperproliferative response.

Authors+Show Affiliations

Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi 110 062, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16119199

Citation

Khan, Naghma, and Sarwat Sultana. "Inhibition of Potassium Bromate-induced Renal Oxidative Stress and Hyperproliferative Response By Nymphaea Alba in Wistar Rats." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 20, no. 3, 2005, pp. 275-83.
Khan N, Sultana S. Inhibition of potassium bromate-induced renal oxidative stress and hyperproliferative response by Nymphaea alba in Wistar rats. J Enzyme Inhib Med Chem. 2005;20(3):275-83.
Khan, N., & Sultana, S. (2005). Inhibition of potassium bromate-induced renal oxidative stress and hyperproliferative response by Nymphaea alba in Wistar rats. Journal of Enzyme Inhibition and Medicinal Chemistry, 20(3), 275-83.
Khan N, Sultana S. Inhibition of Potassium Bromate-induced Renal Oxidative Stress and Hyperproliferative Response By Nymphaea Alba in Wistar Rats. J Enzyme Inhib Med Chem. 2005;20(3):275-83. PubMed PMID: 16119199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of potassium bromate-induced renal oxidative stress and hyperproliferative response by Nymphaea alba in Wistar rats. AU - Khan,Naghma, AU - Sultana,Sarwat, PY - 2005/8/27/pubmed PY - 2005/12/13/medline PY - 2005/8/27/entrez SP - 275 EP - 83 JF - Journal of enzyme inhibition and medicinal chemistry JO - J Enzyme Inhib Med Chem VL - 20 IS - 3 N2 - KBrO3-mediated renal injury and hyperproliferative response in Wistar rats. In this communication, we report the efficacy of Nymphaea alba on KBrO3 (125 mg/kg body weight, intraperitoneally) caused reduction in renal glutathione content, renal antioxidant enzymes and phase-II metabolising enzymes with enhancement in xanthine oxidase, lipid peroxidation, gamma-glutamyl transpeptidase and hydrogen peroxide (H202). It also induced blood urea nitrogen, serum creatinine and tumor promotion markers, viz., ornithine decarboxylase (ODC) activity and DNA synthesis. Treatment of rats with Nymphaea alba (100 and 200 mg/kg body weight) one hour before KBrO3 (125 mg/kg body weight, i.p.) resulted in significant decreases in xanthine oxidase (P < 0.05), lipid peroxidation, gamma-glutamyl transpeptidase, H202 generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Renal glutathione content, glutathione metabolizing enzymes and antioxidant enzymes were also recovered to significant levels (P < 0.001). These results show that Nymphaea alba acts as chemopreventive agent against KBrO3-mediated renal injury and hyperproliferative response. SN - 1475-6366 UR - https://www.unboundmedicine.com/medline/citation/16119199/Inhibition_of_potassium_bromate_induced_renal_oxidative_stress_and_hyperproliferative_response_by_Nymphaea_alba_in_Wistar_rats_ DB - PRIME DP - Unbound Medicine ER -