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Short and long term association of a single serum cholesterol measurement in middle-aged men in prediction of fatal coronary and other cardiovascular events: a cross-cultural comparison through Europe.
Eur J Epidemiol. 2005; 20(7):597-604.EJ

Abstract

AIMS

The purpose was to study the association of a single serum cholesterol measurement with early and late coronary and other cardiovascular deaths during 35 years of follow-up in samples of men aged 40-59 years in five European countries.

METHODS AND RESULTS

A single serum total cholesterol measurement was considered in samples from Finland (N = 1563), the Netherlands (N = 811), Italy (N = 1642), Serbia (N = 1537) and Greece (N = 1158) (total = 6711). Seven partitioned proportional hazards models were solved, one for each of seven independent 5-year blocks, to predict coronary, stroke, cardiovascular disease and all-cause mortality risk. Partitioned hazard scores were cumulated. The resulting curves showed a relatively constant strength in risk for coronary deaths as a function of baseline serum cholesterol levels, although a strong relationship during the first 10-year period was followed by a weaker relationship later on. The pooled estimates for the five countries gave a relative risk for 1 mmol/l of serum cholesterol (95% confidence intervals) of 1.44 (1.23-1.68) for the first period; 1.52 (1.31-1.76) for the second period; and 1.16 (1.02-1.32) for the third period; 1.18 (1.05-1.32) for the forth period; 1.17 (1.05-1.31) for the fifth period; 1.22 (1.10-1.35) for the sixth period; 1.18 (1.05-1.32) for the seventh 5-year period of follow-up. No significant relationship were found between serum cholesterol and stroke and all-cause mortality, while intermediate findings were obtained for cardiovascular diseases.

CONCLUSION

A single serum cholesterol measurement in middle aged-men maintains a strong relationship with the occurrence of coronary heart disease (CHD) deaths during 35 years of follow-up.

Authors+Show Affiliations

Association for Cardiac Research, Associazione per la Ricerca Cardiologica, Rome, Italy. menottia@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16119433

Citation

Menotti, Alessandro, et al. "Short and Long Term Association of a Single Serum Cholesterol Measurement in Middle-aged Men in Prediction of Fatal Coronary and Other Cardiovascular Events: a Cross-cultural Comparison Through Europe." European Journal of Epidemiology, vol. 20, no. 7, 2005, pp. 597-604.
Menotti A, Lanti M, Kromhout D, et al. Short and long term association of a single serum cholesterol measurement in middle-aged men in prediction of fatal coronary and other cardiovascular events: a cross-cultural comparison through Europe. Eur J Epidemiol. 2005;20(7):597-604.
Menotti, A., Lanti, M., Kromhout, D., Kafatos, A., Nedeljkovic, S., & Nissinen, A. (2005). Short and long term association of a single serum cholesterol measurement in middle-aged men in prediction of fatal coronary and other cardiovascular events: a cross-cultural comparison through Europe. European Journal of Epidemiology, 20(7), 597-604.
Menotti A, et al. Short and Long Term Association of a Single Serum Cholesterol Measurement in Middle-aged Men in Prediction of Fatal Coronary and Other Cardiovascular Events: a Cross-cultural Comparison Through Europe. Eur J Epidemiol. 2005;20(7):597-604. PubMed PMID: 16119433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short and long term association of a single serum cholesterol measurement in middle-aged men in prediction of fatal coronary and other cardiovascular events: a cross-cultural comparison through Europe. AU - Menotti,Alessandro, AU - Lanti,Mariapaola, AU - Kromhout,Daan, AU - Kafatos,Anthony, AU - Nedeljkovic,Srecko, AU - Nissinen,Aulikki, PY - 2005/8/27/pubmed PY - 2006/7/29/medline PY - 2005/8/27/entrez SP - 597 EP - 604 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 20 IS - 7 N2 - AIMS: The purpose was to study the association of a single serum cholesterol measurement with early and late coronary and other cardiovascular deaths during 35 years of follow-up in samples of men aged 40-59 years in five European countries. METHODS AND RESULTS: A single serum total cholesterol measurement was considered in samples from Finland (N = 1563), the Netherlands (N = 811), Italy (N = 1642), Serbia (N = 1537) and Greece (N = 1158) (total = 6711). Seven partitioned proportional hazards models were solved, one for each of seven independent 5-year blocks, to predict coronary, stroke, cardiovascular disease and all-cause mortality risk. Partitioned hazard scores were cumulated. The resulting curves showed a relatively constant strength in risk for coronary deaths as a function of baseline serum cholesterol levels, although a strong relationship during the first 10-year period was followed by a weaker relationship later on. The pooled estimates for the five countries gave a relative risk for 1 mmol/l of serum cholesterol (95% confidence intervals) of 1.44 (1.23-1.68) for the first period; 1.52 (1.31-1.76) for the second period; and 1.16 (1.02-1.32) for the third period; 1.18 (1.05-1.32) for the forth period; 1.17 (1.05-1.31) for the fifth period; 1.22 (1.10-1.35) for the sixth period; 1.18 (1.05-1.32) for the seventh 5-year period of follow-up. No significant relationship were found between serum cholesterol and stroke and all-cause mortality, while intermediate findings were obtained for cardiovascular diseases. CONCLUSION: A single serum cholesterol measurement in middle aged-men maintains a strong relationship with the occurrence of coronary heart disease (CHD) deaths during 35 years of follow-up. SN - 0393-2990 UR - https://www.unboundmedicine.com/medline/citation/16119433/Short_and_long_term_association_of_a_single_serum_cholesterol_measurement_in_middle_aged_men_in_prediction_of_fatal_coronary_and_other_cardiovascular_events:_a_cross_cultural_comparison_through_Europe_ L2 - https://www.springerlink.com/openurl.asp?genre=article&issn=0393-2990&volume=20&issue=7&spage=597 DB - PRIME DP - Unbound Medicine ER -