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New antiepileptic drugs--an overview.
Rocz Akad Med Bialymst 2005; 50 Suppl 1:96-8RA

Abstract

The last ten years of the 20th century is called in neuroscience "decade of the brain". This period has brought many new antiepileptic drugs (AEDs) to the practising physician. New AEDs include: vigabatrin, lamotrigine, topiramate, tiagabine, gabapentin, oxcarbazepine, levetiracetam and zonisamide (not registered in Poland). The development of these drugs was under the current epilepsy theory (balance-disturbances between inhibitory and excitatory neurotransmitters in the brain). Mechanism of action of the new AEDs is due to increase of the GABA-system activity and/or reaction with ion-channels events in neurons. The aim of the study was an overview of the current literature on the new AEDs in the treatment of seizures and epileptic syndromes. Data from literature show that the new AEDs are better tolerated, have fewer drug interactions and seem to affect cognitive functions to a lesser degree compared to the conventional drugs. Most of them are recommended to an add-on therapy of partial seizures with/without second generalization, although there are more evidences on efficacy of new AEDs in monotherapy. The new AEDs seemed to be similar to the conventional drugs in efficacy, but superior in tolerability. New AEDs with more selective activity and lower toxicity have been significant improved the quality of life in the epileptic patients. Numerous chemical compounds with potential antiepileptic activity are in experimental and clinical development.

Authors+Show Affiliations

Department of Child Neurology and Rehabilitation, Medical University of Białystok, Poland. krsen@mp.plNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16119637

Citation

Sendrowski, K, and W Sobaniec. "New Antiepileptic Drugs--an Overview." Roczniki Akademii Medycznej W Bialymstoku (1995), vol. 50 Suppl 1, 2005, pp. 96-8.
Sendrowski K, Sobaniec W. New antiepileptic drugs--an overview. Rocz Akad Med Bialymst. 2005;50 Suppl 1:96-8.
Sendrowski, K., & Sobaniec, W. (2005). New antiepileptic drugs--an overview. Roczniki Akademii Medycznej W Bialymstoku (1995), 50 Suppl 1, pp. 96-8.
Sendrowski K, Sobaniec W. New Antiepileptic Drugs--an Overview. Rocz Akad Med Bialymst. 2005;50 Suppl 1:96-8. PubMed PMID: 16119637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New antiepileptic drugs--an overview. AU - Sendrowski,K, AU - Sobaniec,W, PY - 2005/8/27/pubmed PY - 2005/10/12/medline PY - 2005/8/27/entrez SP - 96 EP - 8 JF - Roczniki Akademii Medycznej w Bialymstoku (1995) JO - Rocz. Akad. Med. Bialymst. VL - 50 Suppl 1 N2 - The last ten years of the 20th century is called in neuroscience "decade of the brain". This period has brought many new antiepileptic drugs (AEDs) to the practising physician. New AEDs include: vigabatrin, lamotrigine, topiramate, tiagabine, gabapentin, oxcarbazepine, levetiracetam and zonisamide (not registered in Poland). The development of these drugs was under the current epilepsy theory (balance-disturbances between inhibitory and excitatory neurotransmitters in the brain). Mechanism of action of the new AEDs is due to increase of the GABA-system activity and/or reaction with ion-channels events in neurons. The aim of the study was an overview of the current literature on the new AEDs in the treatment of seizures and epileptic syndromes. Data from literature show that the new AEDs are better tolerated, have fewer drug interactions and seem to affect cognitive functions to a lesser degree compared to the conventional drugs. Most of them are recommended to an add-on therapy of partial seizures with/without second generalization, although there are more evidences on efficacy of new AEDs in monotherapy. The new AEDs seemed to be similar to the conventional drugs in efficacy, but superior in tolerability. New AEDs with more selective activity and lower toxicity have been significant improved the quality of life in the epileptic patients. Numerous chemical compounds with potential antiepileptic activity are in experimental and clinical development. UR - https://www.unboundmedicine.com/medline/citation/16119637/New_antiepileptic_drugs__an_overview_ L2 - https://medlineplus.gov/epilepsy.html DB - PRIME DP - Unbound Medicine ER -