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Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors.
Indian J Exp Biol. 2005 Aug; 43(8):715-21.IJ

Abstract

The standardized methanolic extract of leaves of O. sanctum (OSE; eugenol content 5%) given in doses of 50-200 mg/kg, orally, twice daily for five days showed dose-dependent ulcer protective effect against cold restraint stress induced gastric ulcers. Optimal effective dose (100 mg/kg) of OSE showed significant ulcer protection against ethanol and pyloric ligation-induced gastric ulcers, but was ineffective against aspirin-induced ulcers. OSE significantly healed ulcers induced by 50% acetic acid after 5 and 10 days treatment OSE (100 mg/kg) significantly inhibited the offensive acid-pepsin secretion and lipid peroxidation and increased the gastric defensive factors like mucin secretion, cellular mucus, and life span of mucosal cells and had antioxidant effect, but did not induce mucosal cell proliferation. The results indicate that the ulcer protective and healing effects of OSE may be due to its effects both on offensive and defensive mucosal factors.

Authors+Show Affiliations

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India. rkgoel_bhu@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16121713

Citation

Goel, R K., et al. "Effect of Standardized Extract of Ocimum Sanctum Linn. On Gastric Mucosal Offensive and Defensive Factors." Indian Journal of Experimental Biology, vol. 43, no. 8, 2005, pp. 715-21.
Goel RK, Sairam K, Dorababu M, et al. Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors. Indian J Exp Biol. 2005;43(8):715-21.
Goel, R. K., Sairam, K., Dorababu, M., Prabha, T., & Rao, C. h. V. (2005). Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors. Indian Journal of Experimental Biology, 43(8), 715-21.
Goel RK, et al. Effect of Standardized Extract of Ocimum Sanctum Linn. On Gastric Mucosal Offensive and Defensive Factors. Indian J Exp Biol. 2005;43(8):715-21. PubMed PMID: 16121713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors. AU - Goel,R K, AU - Sairam,K, AU - Dorababu,M, AU - Prabha,T, AU - Rao,Ch V, PY - 2005/8/27/pubmed PY - 2005/9/10/medline PY - 2005/8/27/entrez SP - 715 EP - 21 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 43 IS - 8 N2 - The standardized methanolic extract of leaves of O. sanctum (OSE; eugenol content 5%) given in doses of 50-200 mg/kg, orally, twice daily for five days showed dose-dependent ulcer protective effect against cold restraint stress induced gastric ulcers. Optimal effective dose (100 mg/kg) of OSE showed significant ulcer protection against ethanol and pyloric ligation-induced gastric ulcers, but was ineffective against aspirin-induced ulcers. OSE significantly healed ulcers induced by 50% acetic acid after 5 and 10 days treatment OSE (100 mg/kg) significantly inhibited the offensive acid-pepsin secretion and lipid peroxidation and increased the gastric defensive factors like mucin secretion, cellular mucus, and life span of mucosal cells and had antioxidant effect, but did not induce mucosal cell proliferation. The results indicate that the ulcer protective and healing effects of OSE may be due to its effects both on offensive and defensive mucosal factors. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/16121713/Effect_of_standardized_extract_of_Ocimum_sanctum_Linn__on_gastric_mucosal_offensive_and_defensive_factors_ DB - PRIME DP - Unbound Medicine ER -