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Neurosurgical causes of scoliosis in patients with myelomeningocele: an evidence-based literature review.
J Neurosurg. 2005 Jul; 103(1 Suppl):24-35.JN

Abstract

OBJECT

Scoliosis in children with myelomeningocele occurs frequently and is multifactorial in origin. The aim of this paper is to review the evidence regarding the causal association, if any, between isolated scoliosis and spinal cord tethering, Chiari malformation, or syringomyelia in this population.

METHODS

A Medline search of the English-language literature from 1966 to 2002 was undertaken. All of the pertinent articles that were identified underwent careful review to determine the strength of the evidence supporting the claim that isolated scoliosis in children with myelomeningocele is related to spinal cord tethering, Chiari malformation, or syringomyelia. The strength of the evidence was graded using the Oxford Centre for Evidence-Based Medicine Levels of Evidence (May 2001). A survey was also sent to practicing pediatric neurosurgeons and the returned responses were evaluated.

CONCLUSIONS

All available studies were classified as Level 4 studies (case series and flawed cohort and case-control studies). Based on the strength of the available data, there may be an association between spinal cord tethering and scoliosis, particularly in those patients with upper lumbar lesions and spinal curves less than 45 degrees. There is little evidence to support a causal relationship between scoliosis and Chiari malformation or syringomyelia in this population.

Authors+Show Affiliations

Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA. mdias@psu.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16122001

Citation

Dias, Mark S.. "Neurosurgical Causes of Scoliosis in Patients With Myelomeningocele: an Evidence-based Literature Review." Journal of Neurosurgery, vol. 103, no. 1 Suppl, 2005, pp. 24-35.
Dias MS. Neurosurgical causes of scoliosis in patients with myelomeningocele: an evidence-based literature review. J Neurosurg. 2005;103(1 Suppl):24-35.
Dias, M. S. (2005). Neurosurgical causes of scoliosis in patients with myelomeningocele: an evidence-based literature review. Journal of Neurosurgery, 103(1 Suppl), 24-35.
Dias MS. Neurosurgical Causes of Scoliosis in Patients With Myelomeningocele: an Evidence-based Literature Review. J Neurosurg. 2005;103(1 Suppl):24-35. PubMed PMID: 16122001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurosurgical causes of scoliosis in patients with myelomeningocele: an evidence-based literature review. A1 - Dias,Mark S, PY - 2005/8/27/pubmed PY - 2005/10/7/medline PY - 2005/8/27/entrez SP - 24 EP - 35 JF - Journal of neurosurgery JO - J Neurosurg VL - 103 IS - 1 Suppl N2 - OBJECT: Scoliosis in children with myelomeningocele occurs frequently and is multifactorial in origin. The aim of this paper is to review the evidence regarding the causal association, if any, between isolated scoliosis and spinal cord tethering, Chiari malformation, or syringomyelia in this population. METHODS: A Medline search of the English-language literature from 1966 to 2002 was undertaken. All of the pertinent articles that were identified underwent careful review to determine the strength of the evidence supporting the claim that isolated scoliosis in children with myelomeningocele is related to spinal cord tethering, Chiari malformation, or syringomyelia. The strength of the evidence was graded using the Oxford Centre for Evidence-Based Medicine Levels of Evidence (May 2001). A survey was also sent to practicing pediatric neurosurgeons and the returned responses were evaluated. CONCLUSIONS: All available studies were classified as Level 4 studies (case series and flawed cohort and case-control studies). Based on the strength of the available data, there may be an association between spinal cord tethering and scoliosis, particularly in those patients with upper lumbar lesions and spinal curves less than 45 degrees. There is little evidence to support a causal relationship between scoliosis and Chiari malformation or syringomyelia in this population. SN - 0022-3085 UR - https://www.unboundmedicine.com/medline/citation/16122001/Neurosurgical_causes_of_scoliosis_in_patients_with_myelomeningocele:_an_evidence_based_literature_review_ L2 - https://thejns.org/doi/10.3171/ped.2005.103.1.0024 DB - PRIME DP - Unbound Medicine ER -