Tags

Type your tag names separated by a space and hit enter

Superficial radial sensory nerve potentials in immune-mediated and diabetic neuropathies.
Clin Neurophysiol. 2005 Oct; 116(10):2330-3.CN

Abstract

OBJECTIVE

The pattern of abnormal median-normal sural sensory nerve action potential (SNAP) is frequently found in acute/chronic inflammatory demyelinating polyneuropathy (AIDP/CIDP), whereas sural/radial SNAP amplitude ratio is sensitive to detect dying-back degeneration. To investigate whether radial SNAP and its amplitude ratio to median or sural SNAP provide additional particular patterns of sensory nerve involvement.

METHODS

Superficial radial, median, and sural SNAPs were recorded in 63 normal subjects and in 132 patients with AIDP/CIDP (n = 22), diabetic neuropathy (n = 83), or other axonal polyneuropathy (n = 27). Median/radial and sural/radial amplitude ratios were examined.

RESULTS

In normal subjects, median/radial ratio was 0.96 +/- 0.05 (mean +/- SEM), and sural/radial ratio was 0.50 +/- 0.03. Compared with normal controls, the median/radial ratio was lower in patients with AIDP/CIDP (0.64 +/- 0.11; P < 0.001) or diabetic neuropathy (0.75 +/- 0.04; P = 0.08), but similar in those with other neuropathy (0.94 +/- 0.10). The sural/radial ratio was higher in the AIDP/CIDP group (0.71 +/- 0.08; P = 0.10), and lower in the diabetic (0.36 +/- 0.03; P < 0.001) and other axonal neuropathy groups (0.40 +/- 0.07; P = 0.08).

CONCLUSIONS

AIDP/CIDP is associated with a reduced median/radial ratio and increased sural/radial ratio, probably reflecting demyelination predominant in the distal nerve terminals. Diabetic neuropathy is characterized by decreases in both median/radial and sural/radial ratios, presumably due to coexistence of carpal tunnel pathology and dying-back degeneration.

SIGNIFICANCE

Comparison of multiple SNAP amplitudes provides information about characteristic distribution patterns of sensory nerve involvement in peripheral neuropathies.

Authors+Show Affiliations

Department of Neurology, Chiba University School of Medicine, Inohana, Japan. nonnon@graduate.chiba-u.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16122982

Citation

Tamura, Noriko, et al. "Superficial Radial Sensory Nerve Potentials in Immune-mediated and Diabetic Neuropathies." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 116, no. 10, 2005, pp. 2330-3.
Tamura N, Kuwabara S, Misawa S, et al. Superficial radial sensory nerve potentials in immune-mediated and diabetic neuropathies. Clin Neurophysiol. 2005;116(10):2330-3.
Tamura, N., Kuwabara, S., Misawa, S., Mori, M., Nakata, M., & Hattori, T. (2005). Superficial radial sensory nerve potentials in immune-mediated and diabetic neuropathies. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 116(10), 2330-3.
Tamura N, et al. Superficial Radial Sensory Nerve Potentials in Immune-mediated and Diabetic Neuropathies. Clin Neurophysiol. 2005;116(10):2330-3. PubMed PMID: 16122982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superficial radial sensory nerve potentials in immune-mediated and diabetic neuropathies. AU - Tamura,Noriko, AU - Kuwabara,Satoshi, AU - Misawa,Sonoko, AU - Mori,Masahiro, AU - Nakata,Miho, AU - Hattori,Takamichi, PY - 2005/02/04/received PY - 2005/06/14/revised PY - 2005/07/03/accepted PY - 2005/8/27/pubmed PY - 2005/11/10/medline PY - 2005/8/27/entrez SP - 2330 EP - 3 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 116 IS - 10 N2 - OBJECTIVE: The pattern of abnormal median-normal sural sensory nerve action potential (SNAP) is frequently found in acute/chronic inflammatory demyelinating polyneuropathy (AIDP/CIDP), whereas sural/radial SNAP amplitude ratio is sensitive to detect dying-back degeneration. To investigate whether radial SNAP and its amplitude ratio to median or sural SNAP provide additional particular patterns of sensory nerve involvement. METHODS: Superficial radial, median, and sural SNAPs were recorded in 63 normal subjects and in 132 patients with AIDP/CIDP (n = 22), diabetic neuropathy (n = 83), or other axonal polyneuropathy (n = 27). Median/radial and sural/radial amplitude ratios were examined. RESULTS: In normal subjects, median/radial ratio was 0.96 +/- 0.05 (mean +/- SEM), and sural/radial ratio was 0.50 +/- 0.03. Compared with normal controls, the median/radial ratio was lower in patients with AIDP/CIDP (0.64 +/- 0.11; P < 0.001) or diabetic neuropathy (0.75 +/- 0.04; P = 0.08), but similar in those with other neuropathy (0.94 +/- 0.10). The sural/radial ratio was higher in the AIDP/CIDP group (0.71 +/- 0.08; P = 0.10), and lower in the diabetic (0.36 +/- 0.03; P < 0.001) and other axonal neuropathy groups (0.40 +/- 0.07; P = 0.08). CONCLUSIONS: AIDP/CIDP is associated with a reduced median/radial ratio and increased sural/radial ratio, probably reflecting demyelination predominant in the distal nerve terminals. Diabetic neuropathy is characterized by decreases in both median/radial and sural/radial ratios, presumably due to coexistence of carpal tunnel pathology and dying-back degeneration. SIGNIFICANCE: Comparison of multiple SNAP amplitudes provides information about characteristic distribution patterns of sensory nerve involvement in peripheral neuropathies. SN - 1388-2457 UR - https://www.unboundmedicine.com/medline/citation/16122982/Superficial_radial_sensory_nerve_potentials_in_immune_mediated_and_diabetic_neuropathies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(05)00274-9 DB - PRIME DP - Unbound Medicine ER -