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[Unsaturated fatty acids intake and breast cancer risk: epidemiological data review].
Bull Cancer 2005; 92(7):658-69BC

Abstract

The relationship between fatty acids and breast cancer has been debated for long, because of the high frequency of breast cancer and the contradictory results from the numerous studies devoted to this issue. The present review includes case-control and prospective studies, according to specified methodological criteria, which estimated the exposure to monounsaturated fatty acids (MUFA) and n-6 and n-3 polyunsaturated fatty acids (PUFA) using dietary questionnaires or markers (plasma, erythrocytes, adipose tissue). The relationship between MUFA intake and breast cancer risk seems to depend on the contributing food : neutral or beneficial for vegetable oil, rather deleterious for animal products. Contrary to data from animal experiments, human studies do not show an increase of breast cancer risk with n-6 PUFA intake. Estimating the risk associated with alpha-linolenic acid appears difficult due to the incompleteness of food composition tables and studies on biomarkers remain few. The same applies to long-chain n-3 PUFA despite the suggestion of a decrease in risk, in agreement with animal studies. However, it is difficult in human to disentangle the effect of nutrient intake from that of contributing foods or even nutritional profile.

Authors+Show Affiliations

Equipe E3N-EPIC, Inserm, Institut Gustave Roussy, 39, rue Camille-Desmoulins, 94805 Villejuif Cedex.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

16123005

Citation

Thiébaut, Anne C M., et al. "[Unsaturated Fatty Acids Intake and Breast Cancer Risk: Epidemiological Data Review]." Bulletin Du Cancer, vol. 92, no. 7, 2005, pp. 658-69.
Thiébaut AC, Chajès V, Clavel-Chapelon F, et al. [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]. Bull Cancer. 2005;92(7):658-69.
Thiébaut, A. C., Chajès, V., Clavel-Chapelon, F., & Gerber, M. (2005). [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]. Bulletin Du Cancer, 92(7), pp. 658-69.
Thiébaut AC, et al. [Unsaturated Fatty Acids Intake and Breast Cancer Risk: Epidemiological Data Review]. Bull Cancer. 2005;92(7):658-69. PubMed PMID: 16123005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]. AU - Thiébaut,Anne C M, AU - Chajès,Véronique, AU - Clavel-Chapelon,Françoise, AU - Gerber,Mariette, PY - 2005/8/27/pubmed PY - 2005/9/10/medline PY - 2005/8/27/entrez SP - 658 EP - 69 JF - Bulletin du cancer JO - Bull Cancer VL - 92 IS - 7 N2 - The relationship between fatty acids and breast cancer has been debated for long, because of the high frequency of breast cancer and the contradictory results from the numerous studies devoted to this issue. The present review includes case-control and prospective studies, according to specified methodological criteria, which estimated the exposure to monounsaturated fatty acids (MUFA) and n-6 and n-3 polyunsaturated fatty acids (PUFA) using dietary questionnaires or markers (plasma, erythrocytes, adipose tissue). The relationship between MUFA intake and breast cancer risk seems to depend on the contributing food : neutral or beneficial for vegetable oil, rather deleterious for animal products. Contrary to data from animal experiments, human studies do not show an increase of breast cancer risk with n-6 PUFA intake. Estimating the risk associated with alpha-linolenic acid appears difficult due to the incompleteness of food composition tables and studies on biomarkers remain few. The same applies to long-chain n-3 PUFA despite the suggestion of a decrease in risk, in agreement with animal studies. However, it is difficult in human to disentangle the effect of nutrient intake from that of contributing foods or even nutritional profile. SN - 1769-6917 UR - https://www.unboundmedicine.com/medline/citation/16123005/[Unsaturated_fatty_acids_intake_and_breast_cancer_risk:_epidemiological_data_review]_ L2 - http://www.jle.com/medline.md?issn=0007-4551&vol=92&iss=7&page=658 DB - PRIME DP - Unbound Medicine ER -