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A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome.
Hum Reprod Update 2006 Jan-Feb; 12(1):13-21HR

Abstract

This meta-analysis was conducted to compare outcomes of conventional IVF in women presenting with polycystic ovary syndrome (PCOS) and non-PCOS patients. Studies in which PCOS patients undergoing IVF were compared with a matched--no male factor--control group were considered for this review. A definition consistent with the Rotterdam consensus criteria of PCOS was required, and all patients within a given study had to be treated with the same ovarian stimulation protocol. Information regarding patient characteristics and pregnancy outcome was also required. Nine out of 290 identified studies reporting data on 458 PCOS patients (793 cycles) and 694 matched controls (1116 cycles) fulfilled these inclusion criteria. PCOS patients demonstrated a significantly reduced chance of oocyte retrieval per started cycle, odds ratio (OR) = 0.5 [95% confidence interval (CI) = 0.2-1.0]. However, no difference was observed in chance of embryo transfer per oocyte retrieval between the groups (OR = 0.7, 95% CI = 0.4-1.3). Significantly more oocytes per retrieval were obtained in PCOS patients compared with controls [random effects estimate 3.4 [95% (CI) = 1.7-5.1)]. The number of oocytes fertilized did not differ significantly between PCOS patients and controls, weighted mean difference (WMD) 0.1 oocytes (95% CI = 21.4-1.6). No significant difference was observed in the clinical pregnancy rates per started cycle, OR = 1.0 (95% CI = 0.8-1.3). The incidence of ovarian hyperstimulation syndrome (OHSS) after oocyte retrieval was rarely reported. This meta-analysis demonstrates an increased cancellation rate, but more oocytes retrieved per retrieval and a lower fertilization rate in PCOS undergoing IVF. Overall, PCOS and control patients achieved similar pregnancy and live birth rates per cycle.

Authors+Show Affiliations

Department of Reproductive Medicine, University Medical Center, Utrecht, The Netherlands. e.heijnen@erasmusmc.nl

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

16123051

Citation

Heijnen, E M E W., et al. "A Meta-analysis of Outcomes of Conventional IVF in Women With Polycystic Ovary Syndrome." Human Reproduction Update, vol. 12, no. 1, 2006, pp. 13-21.
Heijnen EM, Eijkemans MJ, Hughes EG, et al. A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome. Hum Reprod Update. 2006;12(1):13-21.
Heijnen, E. M., Eijkemans, M. J., Hughes, E. G., Laven, J. S., Macklon, N. S., & Fauser, B. C. (2006). A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome. Human Reproduction Update, 12(1), pp. 13-21.
Heijnen EM, et al. A Meta-analysis of Outcomes of Conventional IVF in Women With Polycystic Ovary Syndrome. Hum Reprod Update. 2006;12(1):13-21. PubMed PMID: 16123051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome. AU - Heijnen,E M E W, AU - Eijkemans,M J C, AU - Hughes,E G, AU - Laven,J S E, AU - Macklon,N S, AU - Fauser,B C J M, Y1 - 2005/08/25/ PY - 2005/8/27/pubmed PY - 2006/1/27/medline PY - 2005/8/27/entrez SP - 13 EP - 21 JF - Human reproduction update JO - Hum. Reprod. Update VL - 12 IS - 1 N2 - This meta-analysis was conducted to compare outcomes of conventional IVF in women presenting with polycystic ovary syndrome (PCOS) and non-PCOS patients. Studies in which PCOS patients undergoing IVF were compared with a matched--no male factor--control group were considered for this review. A definition consistent with the Rotterdam consensus criteria of PCOS was required, and all patients within a given study had to be treated with the same ovarian stimulation protocol. Information regarding patient characteristics and pregnancy outcome was also required. Nine out of 290 identified studies reporting data on 458 PCOS patients (793 cycles) and 694 matched controls (1116 cycles) fulfilled these inclusion criteria. PCOS patients demonstrated a significantly reduced chance of oocyte retrieval per started cycle, odds ratio (OR) = 0.5 [95% confidence interval (CI) = 0.2-1.0]. However, no difference was observed in chance of embryo transfer per oocyte retrieval between the groups (OR = 0.7, 95% CI = 0.4-1.3). Significantly more oocytes per retrieval were obtained in PCOS patients compared with controls [random effects estimate 3.4 [95% (CI) = 1.7-5.1)]. The number of oocytes fertilized did not differ significantly between PCOS patients and controls, weighted mean difference (WMD) 0.1 oocytes (95% CI = 21.4-1.6). No significant difference was observed in the clinical pregnancy rates per started cycle, OR = 1.0 (95% CI = 0.8-1.3). The incidence of ovarian hyperstimulation syndrome (OHSS) after oocyte retrieval was rarely reported. This meta-analysis demonstrates an increased cancellation rate, but more oocytes retrieved per retrieval and a lower fertilization rate in PCOS undergoing IVF. Overall, PCOS and control patients achieved similar pregnancy and live birth rates per cycle. SN - 1355-4786 UR - https://www.unboundmedicine.com/medline/citation/16123051/A_meta_analysis_of_outcomes_of_conventional_IVF_in_women_with_polycystic_ovary_syndrome_ L2 - https://academic.oup.com/humupd/article-lookup/doi/10.1093/humupd/dmi036 DB - PRIME DP - Unbound Medicine ER -