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Antifungal activity of artemisinin derivatives.
J Nat Prod. 2005 Aug; 68(8):1274-6.JN

Abstract

A series of 29 artemisinin derivatives (2-30), including four new compounds (16-18, 20), together with artemisinin (1), artemisinic acid (31), and arteannuin B (32), were tested for antifungal activity against two opportunistic pathogens, Candida albicans and Cryptoccocus neoformans. Of all the compounds tested, anhydrodihydro-artemisinin (3) demonstrated more potent antifungal activity against C. neoformans than amphotericin B. Also, beta-arteether (7) and alpha-arteether (8) showed marked activity against C. neoformans. Against C. albicans, the overall antifungal effect of these compounds was weak or negligible. Derivatives 2-30 were prepared according to literature procedures.

Authors+Show Affiliations

Galal AM
College of Pharmacy, Cairo University, Kasr El-Eini Street, 11562, Cairo, Egypt. amgalalv@yahoo.com
Ross SA
No affiliation info available
Jacob M
No affiliation info available
ElSohly MA
No affiliation info available

MeSH

Antifungal AgentsArtemisininsCandida albicansCombinatorial Chemistry TechniquesCryptococcus neoformansMicrobial Sensitivity TestsMolecular Structure

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16124777

Citation

Galal, Ahmed M., et al. "Antifungal Activity of Artemisinin Derivatives." Journal of Natural Products, vol. 68, no. 8, 2005, pp. 1274-6.
Galal AM, Ross SA, Jacob M, et al. Antifungal activity of artemisinin derivatives. J Nat Prod. 2005;68(8):1274-6.
Galal, A. M., Ross, S. A., Jacob, M., & ElSohly, M. A. (2005). Antifungal activity of artemisinin derivatives. Journal of Natural Products, 68(8), 1274-6.
Galal AM, et al. Antifungal Activity of Artemisinin Derivatives. J Nat Prod. 2005;68(8):1274-6. PubMed PMID: 16124777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal activity of artemisinin derivatives. AU - Galal,Ahmed M, AU - Ross,Samir A, AU - Jacob,Melissa, AU - ElSohly,Mahmoud A, PY - 2005/8/30/pubmed PY - 2005/10/20/medline PY - 2005/8/30/entrez SP - 1274 EP - 6 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 8 N2 - A series of 29 artemisinin derivatives (2-30), including four new compounds (16-18, 20), together with artemisinin (1), artemisinic acid (31), and arteannuin B (32), were tested for antifungal activity against two opportunistic pathogens, Candida albicans and Cryptoccocus neoformans. Of all the compounds tested, anhydrodihydro-artemisinin (3) demonstrated more potent antifungal activity against C. neoformans than amphotericin B. Also, beta-arteether (7) and alpha-arteether (8) showed marked activity against C. neoformans. Against C. albicans, the overall antifungal effect of these compounds was weak or negligible. Derivatives 2-30 were prepared according to literature procedures. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16124777/Antifungal_activity_of_artemisinin_derivatives_ DB - PRIME DP - Unbound Medicine ER -