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Impact of C-reactive protein on the likelihood of peripheral arterial disease in United States adults with the metabolic syndrome, diabetes mellitus, and preexisting cardiovascular disease.
Am J Cardiol 2005; 96(5):655-8AJ

Abstract

We sought to determine, in United States (US) patients with the metabolic syndrome (MS), diabetes mellitus (DM), or preexisting cardiovascular disease, whether higher levels of C-reactive protein (CRP) would identify those with an increased likelihood of peripheral arterial disease (PAD). In a cross-sectional evaluation of the National Health and Nutrition Examination Survey (NHANES), 1999 to 2000, of 1,600 adults (representing a US population of 62.9 million) aged > or =40 years who had valid ankle-brachial index measurements available, subjects were categorized as having MS (without DM), DM, preexisting cardiovascular disease, or none of these conditions. The presence of PAD was defined as an ankle-brachial index <0.9. Subjects were also divided into groups according to CRP levels that were low (<1 mg/L), intermediate (1 to 3 mg/L), and elevated (>3.0 mg/L). Weighted multiple logistic regression analysis examined the odds of PAD by CRP group and disease category compared with the reference group of subjects who did not have MS, DM, or cardiovascular disease and had a CRP level of <1 mg/L. Those with MS (including DM) had an increased likelihood of PAD (odds ratio 4.8, 95% confidence interval 1.4 to 16.1, p = 0.01) as did those with MS without diabetes and an elevated CRP level (odds ratio 3.9, 95% confidence interval 1.1 to 14.6, p = 0.04); those with DM and an elevated CRP had the highest likelihood of PAD (odds ratio 8.6, 95% confidence interval 2.2 to 34.0, p = 0.001). In conclusion, the likelihood of PAD in US adults with MS and DM is enhanced by elevated CRP levels.

Authors+Show Affiliations

Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, University of California, Irvine, School of Medicine, Irvine, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16125489

Citation

Vu, John D., et al. "Impact of C-reactive Protein On the Likelihood of Peripheral Arterial Disease in United States Adults With the Metabolic Syndrome, Diabetes Mellitus, and Preexisting Cardiovascular Disease." The American Journal of Cardiology, vol. 96, no. 5, 2005, pp. 655-8.
Vu JD, Vu JB, Pio JR, et al. Impact of C-reactive protein on the likelihood of peripheral arterial disease in United States adults with the metabolic syndrome, diabetes mellitus, and preexisting cardiovascular disease. Am J Cardiol. 2005;96(5):655-8.
Vu, J. D., Vu, J. B., Pio, J. R., Malik, S., Franklin, S. S., Chen, R. S., & Wong, N. D. (2005). Impact of C-reactive protein on the likelihood of peripheral arterial disease in United States adults with the metabolic syndrome, diabetes mellitus, and preexisting cardiovascular disease. The American Journal of Cardiology, 96(5), pp. 655-8.
Vu JD, et al. Impact of C-reactive Protein On the Likelihood of Peripheral Arterial Disease in United States Adults With the Metabolic Syndrome, Diabetes Mellitus, and Preexisting Cardiovascular Disease. Am J Cardiol. 2005 Sep 1;96(5):655-8. PubMed PMID: 16125489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of C-reactive protein on the likelihood of peripheral arterial disease in United States adults with the metabolic syndrome, diabetes mellitus, and preexisting cardiovascular disease. AU - Vu,John D, AU - Vu,Jack B, AU - Pio,Jose R, AU - Malik,Shaista, AU - Franklin,Stanley S, AU - Chen,Roland S, AU - Wong,Nathan D, PY - 2005/01/04/received PY - 2005/04/13/revised PY - 2005/04/13/accepted PY - 2005/8/30/pubmed PY - 2005/10/7/medline PY - 2005/8/30/entrez SP - 655 EP - 8 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 96 IS - 5 N2 - We sought to determine, in United States (US) patients with the metabolic syndrome (MS), diabetes mellitus (DM), or preexisting cardiovascular disease, whether higher levels of C-reactive protein (CRP) would identify those with an increased likelihood of peripheral arterial disease (PAD). In a cross-sectional evaluation of the National Health and Nutrition Examination Survey (NHANES), 1999 to 2000, of 1,600 adults (representing a US population of 62.9 million) aged > or =40 years who had valid ankle-brachial index measurements available, subjects were categorized as having MS (without DM), DM, preexisting cardiovascular disease, or none of these conditions. The presence of PAD was defined as an ankle-brachial index <0.9. Subjects were also divided into groups according to CRP levels that were low (<1 mg/L), intermediate (1 to 3 mg/L), and elevated (>3.0 mg/L). Weighted multiple logistic regression analysis examined the odds of PAD by CRP group and disease category compared with the reference group of subjects who did not have MS, DM, or cardiovascular disease and had a CRP level of <1 mg/L. Those with MS (including DM) had an increased likelihood of PAD (odds ratio 4.8, 95% confidence interval 1.4 to 16.1, p = 0.01) as did those with MS without diabetes and an elevated CRP level (odds ratio 3.9, 95% confidence interval 1.1 to 14.6, p = 0.04); those with DM and an elevated CRP had the highest likelihood of PAD (odds ratio 8.6, 95% confidence interval 2.2 to 34.0, p = 0.001). In conclusion, the likelihood of PAD in US adults with MS and DM is enhanced by elevated CRP levels. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/16125489/Impact_of_C_reactive_protein_on_the_likelihood_of_peripheral_arterial_disease_in_United_States_adults_with_the_metabolic_syndrome_diabetes_mellitus_and_preexisting_cardiovascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(05)00934-3 DB - PRIME DP - Unbound Medicine ER -