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Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies in patients with type 2 diabetes mellitus.
Ann N Y Acad Sci. 2005 Jun; 1051:97-103.AN

Abstract

Diabetes mellitus (DM) is associated with a high incidence of atherosclerotic cardiovascular complications that result from chronic metabolic abnormalities such as hyperglycemia-induced oxidative stress. The oxidative-modification of low-density lipoproteins (oxLDL) and oxLDL/beta(2)-GPI complex formation have been reported in patients with autoimmune disorders. OxLDL/beta(2)-GPI complexes and autoantibodies to these complexes were measured by ELISA in serum samples from 50 type 2 DM patients and 50 age/sex-matched healthy controls. Mean OD for oxLDL/beta(2)-GPI complexes in DM was 0.099 +/- 0.065 with 50% of patients reacting above the assay cutoff (P < 0.001 vs. controls). Mean OD for controls was 0.037 +/- 0.015 with 2% positives. Thirty-six (72%) DM patients were taking cholesterol-lowering statins and had a significantly lower mean OD complex level (0.092 +/- 0.071, P = 0.05) compared to patients not taking statins (0.112 +/- 0.05). Mean OD for IgG anti-oxLDL/beta(2)-GPI antibodies in DM was 0.157 +/- 0.112, similar to the controls (0.146 +/- 0.098, P = 0.328). Increased serum levels of oxLDL/beta(2)-GPI complexes may be a consequence of oxidative stress and LDL modification in DM. Lower levels of oxLDL/beta(2)GPI complexes in DM patients taking statins are in agreement with the antioxidant and antithrombotic properties of these drugs. No significant IgG autoantibody production was observed in this group of DM patients. The interaction of oxLDL with beta(2)-GPI in circulation suggests the intriguing possibility that oxLDL/beta(2)-GPI complexes may also play a role in the development of atherosclerosis and/or cardiovascular complications in DM.

Authors+Show Affiliations

Corgenix Inc., 12061 Tejon Street, Westminster, CO 80234, USA. llopez@corgenix.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16126948

Citation

Lopez, Luis R., et al. "Oxidized Low-density Lipoprotein/beta2-glycoprotein I Complexes and Autoantibodies in Patients With Type 2 Diabetes Mellitus." Annals of the New York Academy of Sciences, vol. 1051, 2005, pp. 97-103.
Lopez LR, Hurley BL, Simpson DF, et al. Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies in patients with type 2 diabetes mellitus. Ann N Y Acad Sci. 2005;1051:97-103.
Lopez, L. R., Hurley, B. L., Simpson, D. F., & Matsuura, E. (2005). Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies in patients with type 2 diabetes mellitus. Annals of the New York Academy of Sciences, 1051, 97-103.
Lopez LR, et al. Oxidized Low-density Lipoprotein/beta2-glycoprotein I Complexes and Autoantibodies in Patients With Type 2 Diabetes Mellitus. Ann N Y Acad Sci. 2005;1051:97-103. PubMed PMID: 16126948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies in patients with type 2 diabetes mellitus. AU - Lopez,Luis R, AU - Hurley,Beth L, AU - Simpson,Daniel F, AU - Matsuura,Eiji, PY - 2005/8/30/pubmed PY - 2006/6/27/medline PY - 2005/8/30/entrez SP - 97 EP - 103 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1051 N2 - Diabetes mellitus (DM) is associated with a high incidence of atherosclerotic cardiovascular complications that result from chronic metabolic abnormalities such as hyperglycemia-induced oxidative stress. The oxidative-modification of low-density lipoproteins (oxLDL) and oxLDL/beta(2)-GPI complex formation have been reported in patients with autoimmune disorders. OxLDL/beta(2)-GPI complexes and autoantibodies to these complexes were measured by ELISA in serum samples from 50 type 2 DM patients and 50 age/sex-matched healthy controls. Mean OD for oxLDL/beta(2)-GPI complexes in DM was 0.099 +/- 0.065 with 50% of patients reacting above the assay cutoff (P < 0.001 vs. controls). Mean OD for controls was 0.037 +/- 0.015 with 2% positives. Thirty-six (72%) DM patients were taking cholesterol-lowering statins and had a significantly lower mean OD complex level (0.092 +/- 0.071, P = 0.05) compared to patients not taking statins (0.112 +/- 0.05). Mean OD for IgG anti-oxLDL/beta(2)-GPI antibodies in DM was 0.157 +/- 0.112, similar to the controls (0.146 +/- 0.098, P = 0.328). Increased serum levels of oxLDL/beta(2)-GPI complexes may be a consequence of oxidative stress and LDL modification in DM. Lower levels of oxLDL/beta(2)GPI complexes in DM patients taking statins are in agreement with the antioxidant and antithrombotic properties of these drugs. No significant IgG autoantibody production was observed in this group of DM patients. The interaction of oxLDL with beta(2)-GPI in circulation suggests the intriguing possibility that oxLDL/beta(2)-GPI complexes may also play a role in the development of atherosclerosis and/or cardiovascular complications in DM. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/16126948/Oxidized_low_density_lipoprotein/beta2_glycoprotein_I_complexes_and_autoantibodies_in_patients_with_type_2_diabetes_mellitus_ L2 - https://doi.org/10.1196/annals.1361.050 DB - PRIME DP - Unbound Medicine ER -