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Antifodrin antibodies in Sjogren's syndrome: a review.
Ann N Y Acad Sci. 2005 Jun; 1051:235-9.AN

Abstract

Establishing the diagnosis of Sjögren's syndrome has been difficult in light of its nonspecific symptoms (dry eyes and mouth) and lack of both sensitive and specific laboratory markers. Recently, antibodies against alpha-fodrin have been characterized: first in animal models of Sjögren's syndrome, and later in humans. Antibodies against alpha-fodrin have been shown to be present in up to 98% of untreated patients. These antibodies are directed against an apoptotic cleavage product of alpha-fodrin. Anti-alpha-fodrin is clearly involved in the pathogenesis of murine models of Sjögren's syndrome. However, in humans, conflicting data have recently been generated with regard to the prevalence of antibodies against alpha-fodrin in the disease. These differences may be caused by interference of treatment with antibody concentrations, but may also reflect varying methods of patient selection. Further studies on untreated patients are needed to establish the diagnostic efficiency of antibodies against alpha-fodrin in Sjögren's syndrome, which may be a potential diagnostic marker in addition to antibodies against Ro. In this review, the potential of antifodrin antibodies as laboratory markers of Sjögren's syndrome is discussed.

Authors+Show Affiliations

Abteilung Klinische Immunologie, Zentrum Innere Medizin der Medizinischen Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. witte.torsten@mh-hannover.de

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16126964

Citation

Witte, Torsten. "Antifodrin Antibodies in Sjogren's Syndrome: a Review." Annals of the New York Academy of Sciences, vol. 1051, 2005, pp. 235-9.
Witte T. Antifodrin antibodies in Sjogren's syndrome: a review. Ann N Y Acad Sci. 2005;1051:235-9.
Witte, T. (2005). Antifodrin antibodies in Sjogren's syndrome: a review. Annals of the New York Academy of Sciences, 1051, 235-9.
Witte T. Antifodrin Antibodies in Sjogren's Syndrome: a Review. Ann N Y Acad Sci. 2005;1051:235-9. PubMed PMID: 16126964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifodrin antibodies in Sjogren's syndrome: a review. A1 - Witte,Torsten, PY - 2005/8/30/pubmed PY - 2006/6/27/medline PY - 2005/8/30/entrez SP - 235 EP - 9 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1051 N2 - Establishing the diagnosis of Sjögren's syndrome has been difficult in light of its nonspecific symptoms (dry eyes and mouth) and lack of both sensitive and specific laboratory markers. Recently, antibodies against alpha-fodrin have been characterized: first in animal models of Sjögren's syndrome, and later in humans. Antibodies against alpha-fodrin have been shown to be present in up to 98% of untreated patients. These antibodies are directed against an apoptotic cleavage product of alpha-fodrin. Anti-alpha-fodrin is clearly involved in the pathogenesis of murine models of Sjögren's syndrome. However, in humans, conflicting data have recently been generated with regard to the prevalence of antibodies against alpha-fodrin in the disease. These differences may be caused by interference of treatment with antibody concentrations, but may also reflect varying methods of patient selection. Further studies on untreated patients are needed to establish the diagnostic efficiency of antibodies against alpha-fodrin in Sjögren's syndrome, which may be a potential diagnostic marker in addition to antibodies against Ro. In this review, the potential of antifodrin antibodies as laboratory markers of Sjögren's syndrome is discussed. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/16126964/Antifodrin_antibodies_in_Sjogren's_syndrome:_a_review_ L2 - https://doi.org/10.1196/annals.1361.064 DB - PRIME DP - Unbound Medicine ER -