Tags

Type your tag names separated by a space and hit enter

A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention.
Aliment Pharmacol Ther 2005; 22(5):387-94AP

Abstract

BACKGROUND

Irritable bowel syndrome is a gastrointestinal disorder of unknown aetiology. The effect of probiotics in this syndrome remains unclear.

AIM

To investigate whether a probiotic mixture containing Lactobacillus rhamnosus GG, L. rhamnosus LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii ssp. shermanii JS is effective in alleviating irritable bowel syndrome symptoms.

METHODS

A total of 103 patients fulfilling the Rome I or II criteria took part in this 6-month, randomized, double-blind placebo-controlled trial. The patients received a probiotic capsule or a placebo capsule daily. Gastrointestinal symptoms and bowel habits were recorded.

RESULTS

At the end the total symptom score (abdominal pain + distension + flatulence + borborygmi) was 7.7 (95% CI: -13.9 to -1.6) points lower in the probiotic group (P = 0.015). This represents a median reduction of 42% in the symptom score of the probiotic group compared with 6% in the placebo group. In individual symptoms, borborygmi was milder in the probiotic group (P = 0.008), and for the rest of the symptoms there was a non-significant trend.

CONCLUSIONS

The results indicate that this probiotic mixture is effective in alleviating irritable bowel syndrome symptoms. Considering the high prevalence of irritable bowel syndrome and the lack of effective therapies, even a slight reduction in symptoms could have positive public health consequences.

Authors+Show Affiliations

Valio Ltd, Research Centre, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16128676

Citation

Kajander, K, et al. "A Probiotic Mixture Alleviates Symptoms in Irritable Bowel Syndrome Patients: a Controlled 6-month Intervention." Alimentary Pharmacology & Therapeutics, vol. 22, no. 5, 2005, pp. 387-94.
Kajander K, Hatakka K, Poussa T, et al. A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. Aliment Pharmacol Ther. 2005;22(5):387-94.
Kajander, K., Hatakka, K., Poussa, T., Färkkilä, M., & Korpela, R. (2005). A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. Alimentary Pharmacology & Therapeutics, 22(5), pp. 387-94.
Kajander K, et al. A Probiotic Mixture Alleviates Symptoms in Irritable Bowel Syndrome Patients: a Controlled 6-month Intervention. Aliment Pharmacol Ther. 2005 Sep 1;22(5):387-94. PubMed PMID: 16128676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. AU - Kajander,K, AU - Hatakka,K, AU - Poussa,T, AU - Färkkilä,M, AU - Korpela,R, PY - 2005/9/1/pubmed PY - 2005/11/15/medline PY - 2005/9/1/entrez SP - 387 EP - 94 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 22 IS - 5 N2 - BACKGROUND: Irritable bowel syndrome is a gastrointestinal disorder of unknown aetiology. The effect of probiotics in this syndrome remains unclear. AIM: To investigate whether a probiotic mixture containing Lactobacillus rhamnosus GG, L. rhamnosus LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii ssp. shermanii JS is effective in alleviating irritable bowel syndrome symptoms. METHODS: A total of 103 patients fulfilling the Rome I or II criteria took part in this 6-month, randomized, double-blind placebo-controlled trial. The patients received a probiotic capsule or a placebo capsule daily. Gastrointestinal symptoms and bowel habits were recorded. RESULTS: At the end the total symptom score (abdominal pain + distension + flatulence + borborygmi) was 7.7 (95% CI: -13.9 to -1.6) points lower in the probiotic group (P = 0.015). This represents a median reduction of 42% in the symptom score of the probiotic group compared with 6% in the placebo group. In individual symptoms, borborygmi was milder in the probiotic group (P = 0.008), and for the rest of the symptoms there was a non-significant trend. CONCLUSIONS: The results indicate that this probiotic mixture is effective in alleviating irritable bowel syndrome symptoms. Considering the high prevalence of irritable bowel syndrome and the lack of effective therapies, even a slight reduction in symptoms could have positive public health consequences. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16128676/A_probiotic_mixture_alleviates_symptoms_in_irritable_bowel_syndrome_patients:_a_controlled_6_month_intervention_ L2 - https://doi.org/10.1111/j.1365-2036.2005.02579.x DB - PRIME DP - Unbound Medicine ER -