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Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan.

Abstract

To examine the possible association of dietary fat and fatty acids with breast cancer risk in a population with a low total fat intake and a high consumption of fish, we analyzed data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 26 291 women aged 40-79 years completed a questionnaire on dietary and other factors. Intakes of fat or fatty acids were estimated by using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 129 breast cancer cases were documented. We found no clear association of total fat intake with breast cancer risk; the multivariate-adjusted RR across quartiles were 1.00, 1.29, 0.95, and 0.80 (95% confidence interval [CI] 0.46-1.38). A significant decrease in the risk was detected for the highest quartile of intake compared with the lowest for fish fat and long-chain n-3 fatty acids; the RR were 0.56 (95% CI 0.33-0.94) and 0.50 (0.30-0.85), respectively. A decreasing trend in risk was also suggested with an increasing intake of saturated fatty acids (trend P = 0.066). Among postmenopausal women at baseline, the highest quartile of vegetable fat intake was associated with a 2.08-fold increase in risk (95% CI 1.05-4.13). This prospective study did not support any increase in the risk of breast cancer associated with total or saturated fat intake, but it suggested the protective effects of the long-chain n-3 fatty acids that are abundant in fish.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Nagoya 464-8681, Japan. wakai@aichi-cc.jp

    , , , , , , , , , , , , ,

    Source

    Cancer science 96:9 2005 Sep pg 590-9

    MeSH

    Adult
    Aged
    Breast Neoplasms
    Dietary Fats
    Fatty Acids
    Female
    Humans
    Japan
    Middle Aged
    Multivariate Analysis
    Postmenopause
    Prospective Studies
    Risk Factors
    Seafood

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16128744

    Citation

    Wakai, Kenji, et al. "Dietary Intakes of Fat and Fatty Acids and Risk of Breast Cancer: a Prospective Study in Japan." Cancer Science, vol. 96, no. 9, 2005, pp. 590-9.
    Wakai K, Tamakoshi K, Date C, et al. Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Cancer Sci. 2005;96(9):590-9.
    Wakai, K., Tamakoshi, K., Date, C., Fukui, M., Suzuki, S., Lin, Y., ... Tamakoshi, A. (2005). Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Cancer Science, 96(9), pp. 590-9.
    Wakai K, et al. Dietary Intakes of Fat and Fatty Acids and Risk of Breast Cancer: a Prospective Study in Japan. Cancer Sci. 2005;96(9):590-9. PubMed PMID: 16128744.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. AU - Wakai,Kenji, AU - Tamakoshi,Koji, AU - Date,Chigusa, AU - Fukui,Mitsuru, AU - Suzuki,Sadao, AU - Lin,Yingsong, AU - Niwa,Yoshimitsu, AU - Nishio,Kazuko, AU - Yatsuya,Hiroshi, AU - Kondo,Takaaki, AU - Tokudome,Shinkan, AU - Yamamoto,Akio, AU - Toyoshima,Hideaki, AU - Tamakoshi,Akiko, AU - ,, PY - 2005/9/1/pubmed PY - 2005/10/28/medline PY - 2005/9/1/entrez SP - 590 EP - 9 JF - Cancer science JO - Cancer Sci. VL - 96 IS - 9 N2 - To examine the possible association of dietary fat and fatty acids with breast cancer risk in a population with a low total fat intake and a high consumption of fish, we analyzed data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 26 291 women aged 40-79 years completed a questionnaire on dietary and other factors. Intakes of fat or fatty acids were estimated by using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 129 breast cancer cases were documented. We found no clear association of total fat intake with breast cancer risk; the multivariate-adjusted RR across quartiles were 1.00, 1.29, 0.95, and 0.80 (95% confidence interval [CI] 0.46-1.38). A significant decrease in the risk was detected for the highest quartile of intake compared with the lowest for fish fat and long-chain n-3 fatty acids; the RR were 0.56 (95% CI 0.33-0.94) and 0.50 (0.30-0.85), respectively. A decreasing trend in risk was also suggested with an increasing intake of saturated fatty acids (trend P = 0.066). Among postmenopausal women at baseline, the highest quartile of vegetable fat intake was associated with a 2.08-fold increase in risk (95% CI 1.05-4.13). This prospective study did not support any increase in the risk of breast cancer associated with total or saturated fat intake, but it suggested the protective effects of the long-chain n-3 fatty acids that are abundant in fish. SN - 1347-9032 UR - https://www.unboundmedicine.com/medline/citation/16128744/Dietary_intakes_of_fat_and_fatty_acids_and_risk_of_breast_cancer:_a_prospective_study_in_Japan_ L2 - https://doi.org/10.1111/j.1349-7006.2005.00084.x DB - PRIME DP - Unbound Medicine ER -