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Relationship of phosphorus and calcium-phosphorus product with mortality in CKD.
Am J Kidney Dis. 2005 Sep; 46(3):455-63.AJ

Abstract

BACKGROUND

Abnormalities of mineral metabolism are prevalent in patients with kidney failure and are associated with increased risk for cardiovascular events. There are limited data investigating relationships of phosphorus and calcium-phosphorus product with outcomes in patients with chronic kidney disease (CKD) stages 3 to 4.

METHODS

Serum phosphorus and calcium were measured at baseline in 840 participants from the randomized cohort of the Modification of Diet in Renal Disease Study. Survival status until December 31, 2000, was obtained from the National Death Index. Cox models were performed to assess the relationship of serum phosphorus level and calcium-phosphorus product with all-cause and cardiovascular disease (CVD) mortality.

RESULTS

Mean serum phosphorus level was 3.8 +/- 0.7 mg/dL (1.23 +/- 0.23 mmol/L), calcium-phosphorus product was 34.7 +/- 6.3 mg2/dL2, and glomerular filtration rate (GFR) was 33 +/- 12 mL/min/1.73 m2 (0.55 +/- 0.20 mL/s/1.73 m2). All-cause and CVD mortality rates were 25% and 15%. Serum phosphorus level was not related to all-cause mortality in multivariable models (P = 0.46). In unadjusted analysis, serum phosphorus level was associated with (hazard ratio [HR] per 1 mg/dL increase, 1.34; 95% confidence interval [CI], 1.05 to 1.71; P = 0.02) increased risk for CVD mortality, but this association was partly attenuated and not statistically significant after adjustment for GFR and other confounders (HR, 1.27; 95% CI, 0.94 to 1.73; P = 0.12). Calcium-phosphorus product was not associated with all-cause mortality in unadjusted (P = 0.23) or multivariate analysis (P = 0.35). Calcium-phosphorus product was related to CVD mortality in unadjusted (HR per 10 mg2/dL2 increase, 1.30; 95% CI, 1.01 to 1.69; P = 0.04) analysis, but this association was not statistically significant after adjustment for GFR and other confounders (HR, 1.22; 95% CI, 0.89 to 1.66; P = 0.23).

CONCLUSION

In the Modification of Diet in Renal Disease Study cohort, serum phosphorus level and calcium-phosphorus product were not statistically associated with all-cause or CVD mortality after adjustment for GFR; however larger studies with additional statistical power are needed to evaluate these relationships, especially in the context of current practice patterns in patients with CKD.

Authors+Show Affiliations

Menon V
Division of Nephrology, Department of Medicine, Tufts-New England Medical Center, Boston, MA, USA.
Greene T
No affiliation info available
Pereira AA
No affiliation info available
Wang X
No affiliation info available
Beck GJ
No affiliation info available
Kusek JW
No affiliation info available
Collins AJ
No affiliation info available
Levey AS
No affiliation info available
Sarnak MJ
No affiliation info available

MeSH

AdultAgedC-Reactive ProteinCalciumCardiovascular DiseasesCause of DeathChronic DiseaseCohort StudiesFemaleGlomerular Filtration RateHumansKidney DiseasesMaleMiddle AgedMortalityPhosphorusProportional Hazards ModelsRandomized Controlled Trials as TopicRisk

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16129207

Citation

Menon, Vandana, et al. "Relationship of Phosphorus and Calcium-phosphorus Product With Mortality in CKD." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 46, no. 3, 2005, pp. 455-63.
Menon V, Greene T, Pereira AA, et al. Relationship of phosphorus and calcium-phosphorus product with mortality in CKD. Am J Kidney Dis. 2005;46(3):455-63.
Menon, V., Greene, T., Pereira, A. A., Wang, X., Beck, G. J., Kusek, J. W., Collins, A. J., Levey, A. S., & Sarnak, M. J. (2005). Relationship of phosphorus and calcium-phosphorus product with mortality in CKD. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 46(3), 455-63.
Menon V, et al. Relationship of Phosphorus and Calcium-phosphorus Product With Mortality in CKD. Am J Kidney Dis. 2005;46(3):455-63. PubMed PMID: 16129207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of phosphorus and calcium-phosphorus product with mortality in CKD. AU - Menon,Vandana, AU - Greene,Tom, AU - Pereira,Arema A, AU - Wang,Xuelei, AU - Beck,Gerald J, AU - Kusek,John W, AU - Collins,Alan J, AU - Levey,Andrew S, AU - Sarnak,Mark J, PY - 2005/04/05/received PY - 2005/05/26/accepted PY - 2005/9/1/pubmed PY - 2005/10/26/medline PY - 2005/9/1/entrez SP - 455 EP - 63 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 46 IS - 3 N2 - BACKGROUND: Abnormalities of mineral metabolism are prevalent in patients with kidney failure and are associated with increased risk for cardiovascular events. There are limited data investigating relationships of phosphorus and calcium-phosphorus product with outcomes in patients with chronic kidney disease (CKD) stages 3 to 4. METHODS: Serum phosphorus and calcium were measured at baseline in 840 participants from the randomized cohort of the Modification of Diet in Renal Disease Study. Survival status until December 31, 2000, was obtained from the National Death Index. Cox models were performed to assess the relationship of serum phosphorus level and calcium-phosphorus product with all-cause and cardiovascular disease (CVD) mortality. RESULTS: Mean serum phosphorus level was 3.8 +/- 0.7 mg/dL (1.23 +/- 0.23 mmol/L), calcium-phosphorus product was 34.7 +/- 6.3 mg2/dL2, and glomerular filtration rate (GFR) was 33 +/- 12 mL/min/1.73 m2 (0.55 +/- 0.20 mL/s/1.73 m2). All-cause and CVD mortality rates were 25% and 15%. Serum phosphorus level was not related to all-cause mortality in multivariable models (P = 0.46). In unadjusted analysis, serum phosphorus level was associated with (hazard ratio [HR] per 1 mg/dL increase, 1.34; 95% confidence interval [CI], 1.05 to 1.71; P = 0.02) increased risk for CVD mortality, but this association was partly attenuated and not statistically significant after adjustment for GFR and other confounders (HR, 1.27; 95% CI, 0.94 to 1.73; P = 0.12). Calcium-phosphorus product was not associated with all-cause mortality in unadjusted (P = 0.23) or multivariate analysis (P = 0.35). Calcium-phosphorus product was related to CVD mortality in unadjusted (HR per 10 mg2/dL2 increase, 1.30; 95% CI, 1.01 to 1.69; P = 0.04) analysis, but this association was not statistically significant after adjustment for GFR and other confounders (HR, 1.22; 95% CI, 0.89 to 1.66; P = 0.23). CONCLUSION: In the Modification of Diet in Renal Disease Study cohort, serum phosphorus level and calcium-phosphorus product were not statistically associated with all-cause or CVD mortality after adjustment for GFR; however larger studies with additional statistical power are needed to evaluate these relationships, especially in the context of current practice patterns in patients with CKD. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/16129207/Relationship_of_phosphorus_and_calcium_phosphorus_product_with_mortality_in_CKD_ DB - PRIME DP - Unbound Medicine ER -