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Impact of diet on prostate cancer: a review.
Prostate Cancer Prostatic Dis 2005; 8(4):304-10PC

Abstract

Epidemiological studies suggest that environmental factors may mediate the transformation of latent prostate cancer into clinically apparent tumors and that diet appears to influence this progression. Close correlations between average per capita fat intake and prostate cancer mortality internationally generated interest in underlying mechanisms for this link, such as through serum levels of androgens, free radicals, proinflammatory fatty acid metabolites, or insulin-like growth factor. Much interest currently lies in the potential of HMG-CoA reductase inhibitors (statins) to play a chemopreventative role in prostate cancer. Lycopene, a potent antioxidant found in tomatoes, may exert a protective effect in the prostate. Selenium and vitamin E have also been shown to decrease the risk of prostate cancer in some men. Calcium may support vitamin D-related antiproliferative effects in prostate cancer. Certain soy proteins, common in the Asian diet, have been shown to inhibit prostate cancer cell growth. Finally, green tea may also have a chemopreventive effect by inducing apoptosis. Despite confounding factors present in clinical studies assessing the effect of diet on cancer risk, the data remain compelling that a variety of nutrients may prevent the development and progression of prostate cancer.

Authors+Show Affiliations

Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1738, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16130015

Citation

Sonn, G A., et al. "Impact of Diet On Prostate Cancer: a Review." Prostate Cancer and Prostatic Diseases, vol. 8, no. 4, 2005, pp. 304-10.
Sonn GA, Aronson W, Litwin MS. Impact of diet on prostate cancer: a review. Prostate Cancer Prostatic Dis. 2005;8(4):304-10.
Sonn, G. A., Aronson, W., & Litwin, M. S. (2005). Impact of diet on prostate cancer: a review. Prostate Cancer and Prostatic Diseases, 8(4), pp. 304-10.
Sonn GA, Aronson W, Litwin MS. Impact of Diet On Prostate Cancer: a Review. Prostate Cancer Prostatic Dis. 2005;8(4):304-10. PubMed PMID: 16130015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of diet on prostate cancer: a review. AU - Sonn,G A, AU - Aronson,W, AU - Litwin,M S, PY - 2005/9/1/pubmed PY - 2006/1/13/medline PY - 2005/9/1/entrez SP - 304 EP - 10 JF - Prostate cancer and prostatic diseases JO - Prostate Cancer Prostatic Dis. VL - 8 IS - 4 N2 - Epidemiological studies suggest that environmental factors may mediate the transformation of latent prostate cancer into clinically apparent tumors and that diet appears to influence this progression. Close correlations between average per capita fat intake and prostate cancer mortality internationally generated interest in underlying mechanisms for this link, such as through serum levels of androgens, free radicals, proinflammatory fatty acid metabolites, or insulin-like growth factor. Much interest currently lies in the potential of HMG-CoA reductase inhibitors (statins) to play a chemopreventative role in prostate cancer. Lycopene, a potent antioxidant found in tomatoes, may exert a protective effect in the prostate. Selenium and vitamin E have also been shown to decrease the risk of prostate cancer in some men. Calcium may support vitamin D-related antiproliferative effects in prostate cancer. Certain soy proteins, common in the Asian diet, have been shown to inhibit prostate cancer cell growth. Finally, green tea may also have a chemopreventive effect by inducing apoptosis. Despite confounding factors present in clinical studies assessing the effect of diet on cancer risk, the data remain compelling that a variety of nutrients may prevent the development and progression of prostate cancer. SN - 1365-7852 UR - https://www.unboundmedicine.com/medline/citation/16130015/Impact_of_diet_on_prostate_cancer:_a_review_ L2 - http://dx.doi.org/10.1038/sj.pcan.4500825 DB - PRIME DP - Unbound Medicine ER -