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Fast access of some grape pigments to the brain.
J Agric Food Chem. 2005 Sep 07; 53(18):7029-34.JA

Abstract

Anthocyanins represent the main flavonoid pigments in red grape and wine, in red berries, and in many other fruits and vegetables and are widespread in the human diet. After ingestion, these complex, hydrophilic compounds quickly appear as intact molecules in the plasma. This study investigated their presence in the brain of anesthetized rats that received 8 mg/kg of body weight of a pure anthocyanin mixture extracted from Vitis vinifera grapes. The mixture was maintained in the stomach for 10 min. After this time, intact anthocyanins were detected by HPLC-DAD-MS not only in the plasma (176.4 +/- 50.5 ng/mL, mean +/- SEM) but also in the brain (192.2 +/- 57.5 ng/g). These results demonstrate for the first time that grape pigments can reach the mammalian brain within minutes from their introduction into the stomach.

Authors+Show Affiliations

Passamonti S
Dipartimento di Biochimica Biofisica e Chimica delle Macromolecole, Università di Trieste, via L. Giorgeri 1, 34127 Trieste, Italy.
Vrhovsek U
No affiliation info available
Vanzo A
No affiliation info available
Mattivi F
No affiliation info available

MeSH

AnimalsAnthocyaninsBrainBrain ChemistryChromatography, High Pressure LiquidFlavonoidsFruitMaleMass SpectrometryRatsRats, WistarVitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16131107

Citation

Passamonti, Sabina, et al. "Fast Access of some Grape Pigments to the Brain." Journal of Agricultural and Food Chemistry, vol. 53, no. 18, 2005, pp. 7029-34.
Passamonti S, Vrhovsek U, Vanzo A, et al. Fast access of some grape pigments to the brain. J Agric Food Chem. 2005;53(18):7029-34.
Passamonti, S., Vrhovsek, U., Vanzo, A., & Mattivi, F. (2005). Fast access of some grape pigments to the brain. Journal of Agricultural and Food Chemistry, 53(18), 7029-34.
Passamonti S, et al. Fast Access of some Grape Pigments to the Brain. J Agric Food Chem. 2005 Sep 7;53(18):7029-34. PubMed PMID: 16131107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fast access of some grape pigments to the brain. AU - Passamonti,Sabina, AU - Vrhovsek,Urska, AU - Vanzo,Andreja, AU - Mattivi,Fulvio, PY - 2005/9/1/pubmed PY - 2005/10/12/medline PY - 2005/9/1/entrez SP - 7029 EP - 34 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 53 IS - 18 N2 - Anthocyanins represent the main flavonoid pigments in red grape and wine, in red berries, and in many other fruits and vegetables and are widespread in the human diet. After ingestion, these complex, hydrophilic compounds quickly appear as intact molecules in the plasma. This study investigated their presence in the brain of anesthetized rats that received 8 mg/kg of body weight of a pure anthocyanin mixture extracted from Vitis vinifera grapes. The mixture was maintained in the stomach for 10 min. After this time, intact anthocyanins were detected by HPLC-DAD-MS not only in the plasma (176.4 +/- 50.5 ng/mL, mean +/- SEM) but also in the brain (192.2 +/- 57.5 ng/g). These results demonstrate for the first time that grape pigments can reach the mammalian brain within minutes from their introduction into the stomach. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16131107/Fast_access_of_some_grape_pigments_to_the_brain_ DB - PRIME DP - Unbound Medicine ER -